QuickView for PDGFRA;jsessionid=834D13CAFD107F8D582533DDFB033B17;jsessionid=9E8BC492040603750BCF1A650161C5BF (gene)

Gene Symbol:

Pdgfra Mus musculus

Full name:

platelet derived growth factor receptor, alpha polypeptide

Synonyms:

AI115593, CD140a, Pdgfr-2, platelet-derived growth factor receptor alpha, Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha), CD140 antigen-like family member A, PDGF alpha chain, PDGF-R-alpha, PDGFR-alpha, alpha-type platelet-derived growth factor receptor

Genomic Location:

Chr 5: 75548316-75594229

Description:

This gene encodes a member of the receptor tyrosine kinase family of proteins. Binding of platelet-derived growth factor protein ligands to this receptor triggers receptor dimerization and autophosphorylation, resulting in the activation of several downstream signaling pathways. Signaling through the encoded receptor plays a role in gastrulation an...

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This gene encodes a member of the receptor tyrosine kinase family of proteins. Binding of platelet-derived growth factor protein ligands to this receptor triggers receptor dimerization and autophosphorylation, resulting in the activation of several downstream signaling pathways. Signaling through the encoded receptor plays a role in gastrulation and the development of nearly all organ systems. Mice lacking a functional copy of this gene reportedly exhibit defects in lung, skeleton, testis and the central nervous system, and die soon after birth. Alternative splicing and intronic polyadenylation of gene transcripts have been implicated in muscle regeneration and fibrosis in adult mice.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AAAYRNCTG_UNKNOWN ,  MEF2_01 ,  RSRFC4_01 ,  GATA2_01 ,  PAX6_01 ,  CEBPB_02 ,  GATA1_02 ,  GATA1_04 ,  HNF1_01 ,  OCT1_03 ,  CEBP_Q2 ,  CEBP_C ,  EN1_01 ,  CCCNNNNNNAAGWT_UNKNOWN ,  RSRFC4_Q2 ,  CART1_01 ,  TGIF_01 ,  NKX61_01 ,  TITF1_Q3 ,  GATA6_01 ,  NKX62_Q2 ,  E2F_03 ,  AFP1_Q6 ,  CTTTAAR_UNKNOWN ,  CEBPGAMMA_Q6 ,  HNF4ALPHA_Q6 ,  HNF6_Q6 ,  MAF_Q6 ,  SMAD4_Q6 ,  HFH4_01 ,  GATA_Q6 ,  HNF1_Q6 ,  MEF2_Q6_01 ,  PR_Q2 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  TACTTGA_MIR26A_MIR26B ,  ACTGTGA_MIR27A_MIR27B ,  ACTACCT_MIR196A_MIR196B ,  TTGGAGA_MIR5155P_MIR519E ,  GTGTGAG_MIR342 ,  CTACTGT_MIR199A ,  TCCCCAC_MIR491 ,  GTGACTT_MIR224 ,  CTGAGCC_MIR24 ,  AAACCAC_MIR140 ,  AAGCACA_MIR218 ,  GAGCCAG_MIR149 ,  ACTGCCT_MIR34B ,  GTTAAAG_MIR302B ,  GACAATC_MIR219 ,  TGTGTGA_MIR377 ,  CAATGCA_MIR33 ,  TGACATY_UNKNOWN ,  YCATTAA_UNKNOWN ,  YKACATTT_UNKNOWN ,  TGANTCA_AP1_C ,  CAGGTA_AREB6_01 ,  TAATTA_CHX10_01 ,  CAGGTG_E12_Q6 ,  RYTTCCTG_ETS2_B ,  TTGTTT_FOXO4_01 ,  TGTTTGY_HNF3_Q6 ,  CTTTGT_LEF1_Q2 ,  YTATTTTNR_MEF2_02 ,  TGACAGNY_MEIS1_01 ,  TGGAAA_NFAT_Q4_01 ,  TAAWWATAG_RSRFC4_Q2 ,  WGGAATGY_TEF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-196 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-342 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-491 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-496

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