QuickView for PLA2G2A;jsessionid=D092035CC0EC4251C969DD42A25CF012;jsessionid=B38524A3A04A6E627F117AA164B6A6A3 (gene)

Gene Symbol:

Pla2g2a Mus musculus

Full name:

phospholipase A2, group IIA (platelets, synovial fluid)

Synonyms:

EF, Mom1, Pla2, sPLA2, sPla2-IIA, phospholipase A2, membrane associated, GIIC sPLA2, enhancing factor, group IIA phospholipase A2, modifier of Min1, non-pancreatic secreted type II phospholipase A2, phosphatidylcholine 2-acylhydrolase 2A, secretory group II phospholipase A2

Genomic Location:

Chr 4: 138387772-138391104

Description:

Proteins belonging to the phospholipase A2 (PLA2) family hydrolyze phospholipids into sn2 fatty acids and lysophospholipids. They function in a variety of cellular processes, including the digestion of phospholipids and the production of molecules that induce inflammatory responses. This gene encodes a member of the group II class of secretory PLA2...

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Proteins belonging to the phospholipase A2 (PLA2) family hydrolyze phospholipids into sn2 fatty acids and lysophospholipids. They function in a variety of cellular processes, including the digestion of phospholipids and the production of molecules that induce inflammatory responses. This gene encodes a member of the group II class of secretory PLA2s. The secreted enzyme binds to heparin on the cell surface. Mutations in this gene increase the occurrence of intestinal polyps caused by a dominant mutation in the adenomatosis polyposis coli gene. A frameshift inactivates this gene product in some mouse strains including the strain of the reference genome, C57BL/6J, whereas a functional protein is produced in other strains.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

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