QuickView for PLA2G2A;jsessionid=D092035CC0EC4251C969DD42A25CF012;jsessionid=117886BF86104445BAF583EDBD12F03C (gene)
- Gene Symbol:
- Pla2g2a
Rattus norvegicus - Full name:
- phospholipase A2 group IIA
- Synonyms:
- sPLA2, phospholipase A2, membrane associated, GIIC sPLA2, eted enzyme type IIA phospholipase A2, group IIA phospholipase A2, phosphatidylcholine 2-acylhydrolase 2A, phospholipase A2, group IIA (platelets, synovial fluid), platelet phospholipase A2
- Genomic Location:
- Chr 5: 157654294-157657361
- Description:
-
hydrolyzes acyl group at the sn-2 position of phospholipids, forming non-esterified fatty acids and lysophospholipids; plays a critical role in inflammation; induces proliferation of smooth muscle cells
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Gallus gallus , Pan troglodytes , Bos taurus
- External Links:
- Entrez Gene
GO Molecular Function
calcium-dependent phospholipase A2 activity | cation binding | phospholipase activity | lipid binding | carboxylic ester hydrolase activity | hydrolase activity | phospholipid binding | catalytic activity | anion binding | phospholipase A2 activity | hydrolase activity, acting on ester bonds | ion binding | lipase activity | phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) | calcium ion binding | metal ion binding | phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
GO Biological Process
regulation of ERK1 and ERK2 cascade | long-chain fatty acid transport | lipid transport | establishment of localization | positive regulation of phosphate metabolic process | phospholipid metabolic process | cellular process | secretion | organic substance catabolic process | monocarboxylic acid transport | localization | anion transport | macromolecule localization | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of metabolic process | catabolic process | positive regulation of cellular protein metabolic process | cellular lipid metabolic process | acid secretion | positive regulation of protein metabolic process | regulation of signal transduction | phosphatidic acid metabolic process | regulation of MAPK cascade | phosphorus metabolic process | lipid metabolic process | regulation of phosphorylation | arachidonic acid secretion | fatty acid transport | organic substance transport | organophosphate metabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | organic acid transport | regulation of cellular protein metabolic process | organic anion transport | phosphate-containing compound metabolic process | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | glycerolipid metabolic process | positive regulation of protein modification process | regulation of intracellular signal transduction | metabolic process | lipid localization | lipid catabolic process | organic substance metabolic process | positive regulation of ERK1 and ERK2 cascade | regulation of phosphate metabolic process | positive regulation of MAPK cascade | regulation of cell communication | positive regulation of phosphorylation | carboxylic acid transport | glycerophospholipid metabolic process | positive regulation of metabolic process | ion transport | cellular metabolic process | positive regulation of signaling | regulation of signaling | regulation of phosphorus metabolic process
GO Cellular Component
secretory granule | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | secretory vesicle | endomembrane system | plasma membrane | vesicle | perinuclear region of cytoplasm | extracellular region | membrane-bounded organelle | organelle | extracellular space | cell periphery | intracellular vesicle | intracellular | membrane
