QuickView for POLB;jsessionid=1960F1E9A35A15B75E8010C774038E47;jsessionid=221D75F83BBA48BB6BEF33221E0279B0 (gene)
- Gene Symbol:
- Polb
Rattus norvegicus - Full name:
- DNA polymerase beta
- Synonyms:
- DNA polymerase beta, DNA pol beta, DNA-directed DNA polymerase beta, polymerase (DNA directed), beta, polymerase (DNA) beta, polymerase-beta
- Genomic Location:
- Chr 16: 73864707-73890114
- Description:
-
plays a role in DNA repair and bypass of pyrimidine dimers produced by UV-irradiation; also involved in base-excision repair
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Gallus gallus , Canis lupus familiaris , Danio rerio , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
cation binding | DNA-directed DNA polymerase activity | enzyme binding | nucleic acid binding | DNA polymerase activity | lyase activity | nucleotidyltransferase activity | catalytic activity | cytoskeletal protein binding | DNA binding | damaged DNA binding | ion binding | organic cyclic compound binding | protein binding | transferase activity, transferring phosphorus-containing groups | transferase activity | microtubule binding | tubulin binding | metal ion binding | heterocyclic compound binding
GO Biological Process
response to radiation | somatic hypermutation of immunoglobulin genes | intracellular signal transduction | neuron death | defense response | intrinsic apoptotic signaling pathway in response to DNA damage | response to drug | response to antibiotic | salivary gland morphogenesis | cellular process | DNA-directed DNA polymerase activity | immune system development | intrinsic apoptotic signaling pathway | somatic diversification of immune receptors via somatic mutation | regulation of cellular process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | response to stimulus | gland morphogenesis | response to stress | cellular nitrogen compound biosynthetic process | DNA polymerase activity | programmed cell death | response to alcohol | cellular nitrogen compound metabolic process | pyrimidine dimer repair | cellular biosynthetic process | DNA recombination | DNA repair | response to ethanol | apoptotic process | system development | response to oxygen levels | nitrogen compound metabolic process | multicellular organism development | cellular response to DNA damage stimulus | spleen development | somatic recombination of immunoglobulin gene segments | DNA biosynthetic process | cellular response to stress | animal organ morphogenesis | neuron apoptotic process | homeostasis of number of cells | V(D)J recombination | biosynthetic process | aromatic compound biosynthetic process | response to hyperoxia | response to toxic substance | response to gamma radiation | cell communication | inflammatory response | base-excision repair | homeostatic process | nucleotide-excision repair, DNA gap filling | apoptotic signaling pathway | lymph node development | response to organic substance | gland development | DNA metabolic process | anatomical structure development | metabolic process | nucleotide-excision repair | immunoglobulin production | somatic diversification of immunoglobulins | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | base-excision repair, gap-filling | animal organ development | signaling | anatomical structure morphogenesis | somatic cell DNA recombination | cellular macromolecule biosynthetic process | developmental process | immunoglobulin heavy chain V-D-J recombination | heterocycle metabolic process | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | exocrine system development | salivary gland development | DNA replication | aging | response to ionizing radiation | immunoglobulin V(D)J recombination | signal transduction | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
supramolecular fiber | intracellular membrane-bounded organelle | cell | microtubule | cytoplasm | spindle | intracellular organelle | protein-containing complex | microtubule cytoskeleton | spindle microtubule | membrane-bounded organelle | nucleus | organelle | cytoskeleton | intracellular | supramolecular complex
