QuickView for PP2A;jsessionid=A3684BAAC8C83B86408FC8961B58A564;jsessionid=653169F742312EE383AAF4E6E0B3678C (gene)

Gene Symbol:

PPP2R1A Homo sapiens

Full name:

protein phosphatase 2 scaffold subunit Aalpha

Synonyms:

MRD36, PP2A-Aalpha, PP2AA, PP2AAALPHA, PR65A, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, PP2A subunit A isoform PR65-alpha, PP2A subunit A isoform R1-alpha, medium tumor antigen-associated 61 KDA protein, protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform, protein phosphatase 2, regulatory subunit A, alpha, protein phosphatase 2A structural subunit A, alpha isoform, serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform, testicular secretory protein Li 1

Genomic Location:

Chr 19: 57385046-57421483

Description:

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that ass...

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This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CGTSACG_PAX3_B ,  GATTGGY_NFY_Q6_01 ,  E2F1_Q4 ,  GTGACGY_E4F1_Q6 ,  NFY_01 ,  GTGTCAA_MIR514 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  SF1_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-15

Cytogenetic Map:

19q13.41

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