QuickView for PPARG;jsessionid=7EDDCE01DD58406CF26F05133FEFE0E1;jsessionid=88D6A8830DD5153CE773F00E7623E497 (gene)

Gene Symbol:

Pparg Mus musculus

Full name:

peroxisome proliferator activated receptor gamma

Synonyms:

Nr1c3, PPAR-gamma, PPAR-gamma2, PPARgamma, PPARgamma2, peroxisome proliferator-activated receptor gamma, nuclear receptor subfamily 1 group C member 3, peroxisome proliferator activated receptor gamma 2, peroxisome proliferator activated receptor gamma 4

Genomic Location:

Chr 6: 115372091-115440419

Description:

This gene encodes a nuclear receptor protein belonging to the peroxisome proliferator-activated receptor (Ppar) family. The encoded protein is a ligand-activated transcription factor that is involved in the regulation of adipocyte differentiation and glucose homeostasis. The encoded protein forms a heterodimer with retinoid X receptors and binds to...

View Full Description

This gene encodes a nuclear receptor protein belonging to the peroxisome proliferator-activated receptor (Ppar) family. The encoded protein is a ligand-activated transcription factor that is involved in the regulation of adipocyte differentiation and glucose homeostasis. The encoded protein forms a heterodimer with retinoid X receptors and binds to DNA motifs termed "peroxisome proliferator response elements" to either activate or inhibit gene expression. Mice lacking the encoded protein die at an embryonic stage due to severe defects in placental vascularization. When the embryos lacking this gene are supplemented with healthy placentas, the mutants survive to term, but succumb to lipodystrophy and multiple hemorrhages. Alternative splicing results in multiple transcript variants encoding different isoforms.

View Less

Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CDPCR3_01 ,  CEBPB_02 ,  HNF4_01 ,  OCT1_03 ,  LYF1_01 ,  AGCYRWTTC_UNKNOWN ,  SRF_Q6 ,  TATA_01 ,  TCF11MAFG_01 ,  PAX2_02 ,  CEBPGAMMA_Q6 ,  TCF1P_Q6 ,  COREBINDINGFACTOR_Q6 ,  HFH4_01 ,  SRF_Q4 ,  SRF_Q5_01 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  ACTGTGA_MIR27A_MIR27B ,  GTGGGTGK_UNKNOWN ,  WTTGKCTG_UNKNOWN ,  YKACATTT_UNKNOWN ,  RACCACAR_AML_Q6 ,  TTAYRTAA_E4BP4_01 ,  CTTTGA_LEF1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  TGCCAAR_NF1_Q6 ,  TATAAA_TATA_01 ,  TGANNYRGCA_TCF11MAFG_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-27

search → result