QuickView for PRC2;jsessionid=8A8006DF6917705839E1BDA14A1BC044;jsessionid=F81A3D77815CA483C424AAD4A809E780 (gene)
- Gene Symbol:
- PSMA6
Homo sapiens - Full name:
- proteasome subunit alpha 6
- Synonyms:
- IOTA, PROS27, p27K, proteasome subunit alpha type-6, 27 kDa prosomal protein, PROS-27, macropain iota chain, macropain subunit iota, multicatalytic endopeptidase complex iota chain, prosomal P27K protein, proteasome (prosome, macropain) subunit, alpha type, 6, proteasome iota chain, proteasome subunit iota, testicular secretory protein Li 44
- Genomic Location:
- Chr 14: 34831325-34856431
- Description:
-
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and ...
- Orthologs:
- Mus musculus , Rattus norvegicus , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Gallus gallus , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
14q13.2
GO Molecular Function
NF-kappaB binding | nucleic acid binding | hydrolase activity | catalytic activity | anion binding | threonine-type endopeptidase activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transcription factor binding | endopeptidase activity | heterocyclic compound binding | peptidase activity | RNA binding
GO Biological Process
protein modification by small protein removal | proteolysis | positive regulation of DNA-binding transcription factor activity | cellular process | organic substance catabolic process | proteolysis involved in cellular protein catabolic process | regulation of cellular process | regulation of metabolic process | catabolic process | protein deubiquitination | cellular protein catabolic process | proteasomal protein catabolic process | protein modification process | macromolecule modification | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | regulation of gene expression | protein catabolic process | threonine-type endopeptidase activity | regulation of nitrogen compound metabolic process | regulation of cellular metabolic process | proteasomal ubiquitin-independent protein catabolic process | regulation of RNA metabolic process | proteasome-mediated ubiquitin-dependent protein catabolic process | positive regulation of molecular function | protein metabolic process | regulation of DNA-binding transcription factor activity | cellular macromolecule catabolic process | metabolic process | regulation of RNA biosynthetic process | organic substance metabolic process | positive regulation of NF-kappaB transcription factor activity | protein modification by small protein conjugation or removal | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | regulation of transcription, DNA-templated | endopeptidase activity | cellular protein metabolic process | cellular protein modification process | cellular metabolic process | peptidase activity | modification-dependent protein catabolic process | regulation of inflammatory response | post-translational protein modification | macromolecule metabolic process
GO Cellular Component
supramolecular fiber | proteasome core complex | intracellular membrane-bounded organelle | catalytic complex | polysome | sarcomere | cell | nuclear lumen | ribonucleoprotein granule | proteasome core complex, alpha-subunit complex | myofibril | cytoplasm | proteasome complex | intracellular organelle | P-body | contractile fiber | protein-containing complex | nucleoplasm | ribonucleoprotein complex | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | cytoplasmic ribonucleoprotein granule | extracellular space | membrane-enclosed lumen | nuclear matrix | cytosol | intracellular | supramolecular complex | nuclear periphery
