QuickView for PRKA;jsessionid=15BF2951EE8AD349D0312CE2BF2935B2;jsessionid=D8D063324858266FFBD6F4224F4ACD8E (gene)

Gene Symbol:

AKAP6 Homo sapiens

Full name:

A-kinase anchoring protein 6

Synonyms:

ADAP100, ADAP6, AKAP100, PRKA6, mAKAP, A-kinase anchor protein 6, A kinase (PRKA) anchor protein 6, A-kinase anchor protein 100 kDa, AKAP 100, AKAP-6, protein kinase A anchoring protein 6

Genomic Location:

Chr 14: 31868274-32372018

Description:

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain r...

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The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGCC_MIR34A_MIR34C_MIR449 ,  P53_DECAMER_Q2 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  CTATGCA_MIR153 ,  TACTTGA_MIR26A_MIR26B ,  P53_02 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  GTGCCTT_MIR506 ,  GATA4_Q3 ,  ISRE_01 ,  TCATCTC_MIR143

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-185 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-543

Cytogenetic Map:

14q12

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