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QuickView for PTGS1;jsessionid=9204AF0BE6C63B7FF5851AC7D0A88FE9;jsessionid=CAC7A14B2BCCFDE5C853C539B32D5BA7 (gene)


Gene Symbol:
Ptgs1 Rattus norvegicus Rattus norvegicus
Full name:
prostaglandin-endoperoxide synthase 1
Synonyms:
Cox-1, Cox-3, Cox1, Cox3, Pghs-1, prostaglandin G/H synthase 1, PGH synthase 1, PHS 1, cyclooxygenase 3, cyclooxygenase-1, prostaglandin G/H synthase and cyclooxygenase, prostaglandin H2 synthase 1
Genomic Location:
Chr 3: 15343832-15365412
Description:
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein...
Orthologs:
Homo sapiens Mus musculus Macaca mulatta Danio rerio Bos taurus Canis lupus familiaris Gallus gallus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:


Transcripts Names
NM_017043
XM_006234063
Protein Names
Q62731
Q66HK3
Q63684



GO Molecular Function

cofactor binding | peroxidase activity | cation binding | antioxidant activity | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | ion binding | organic cyclic compound binding | tetrapyrrole binding | prostaglandin-endoperoxide synthase activity | dioxygenase activity | heme binding | oxidoreductase activity, acting on peroxide as acceptor | metal ion binding | heterocyclic compound binding | oxidoreductase activity

GO Biological Process

regulation of blood vessel diameter | regulation of muscle system process | positive regulation of blood circulation | regulation of localization | response to hormone | negative regulation of cellular process | peroxidase activity | defense response | regulation of smooth muscle contraction | cellular process | unsaturated fatty acid biosynthetic process | regulation of catecholamine secretion | cellular detoxification | antioxidant activity | negative regulation of signaling | learning | negative regulation of secretion | response to corticosterone | negative regulation of hormone secretion | positive regulation of vasoconstriction | regulation of cellular process | icosanoid biosynthetic process | cellular lipid metabolic process | response to stimulus | monocarboxylic acid metabolic process | regulation of blood vessel size | regulation of norepinephrine secretion | response to stress | regulation of cell proliferation | cyclooxygenase pathway | regulation of blood circulation | response to alcohol | cellular response to toxic substance | negative regulation of transport | blood circulation | cellular biosynthetic process | negative regulation of blood vessel diameter | response to nitrogen compound | negative regulation of epinephrine secretion | negative regulation of secretion by cell | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | learning or memory | response to fatty acid | regulation of muscle contraction | lipid metabolic process | regulation of hormone levels | regulation of hormone secretion | response to ketone | response to lipid | nervous system process | regulation of blood pressure | small molecule metabolic process | response to corticosteroid | response to oxidative stress | negative regulation of norepinephrine secretion | cognition | fatty acid biosynthetic process | biosynthetic process | sensory perception of pain | lipid biosynthetic process | response to toxic substance | positive regulation of smooth muscle contraction | inflammatory response | regulation of tube size | long-chain fatty acid metabolic process | negative regulation of catecholamine secretion | carboxylic acid metabolic process | response to organic substance | regulation of vasoconstriction | metabolic process | response to mineralocorticoid | cellular oxidant detoxification | oxidation-reduction process | regulation of tube diameter | prostaglandin-endoperoxide synthase activity | prostaglandin metabolic process | regulation of secretion | behavior | positive regulation of muscle contraction | organic substance metabolic process | dioxygenase activity | fatty acid metabolic process | memory | sensory perception | icosanoid metabolic process | regulation of cell communication | maintenance of permeability of blood-brain barrier | response to organic cyclic compound | organic acid metabolic process | developmental process | regulation of transport | detoxification | response to organonitrogen compound | prostaglandin biosynthetic process | oxidoreductase activity, acting on peroxide as acceptor | cellular metabolic process | oxidoreductase activity | response to steroid hormone | aging | arachidonic acid metabolic process | regulation of signaling | response to glucocorticoid | multicellular organismal process

GO Cellular Component

non-motile cilium | intracellular membrane-bounded organelle | neuron projection | organelle membrane | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | cell projection | endomembrane system | endoplasmic reticulum membrane | nuclear envelope | cilium | photoreceptor outer segment | 9+0 non-motile cilium | photoreceptor cell cilium | membrane-bounded organelle | nucleus | organelle | intracellular | membrane