QuickView for PTGS2;jsessionid=8AD64C1577AAAC02DA9C6E82A3BEE2A9;jsessionid=46570D3FA182C2EC9D1F2D5B213D49D0 (gene)

Gene Symbol:

Ptgs2 Mus musculus

Full name:

prostaglandin-endoperoxide synthase 2

Synonyms:

COX2, Cox-2, PES-2, PGHS-2, PHS II, PHS-2, Pghs2, TIS10, gripghs, prostaglandin G/H synthase 2, PGH synthase 2, cyclooxygenase-2, glucocorticoid-regulated inflammatory cyclooxygenase, macrophage activation-associated marker protein P71/73, prostaglandin H2 synthase 2

Genomic Location:

Chr 1: 151947254-151955147

Description:

This gene encodes an enzyme that is a member of the prostaglandin G/H synthase family. The encoded protein converts arachidonic acid to prostaglandin endoperoxide H2 which is a key enzymatic step in prostaglandin biosynthesis. This gene is the inducible prostaglandin G/H synthase family member that is upregulated during inflammation. Aberrant regul...

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This gene encodes an enzyme that is a member of the prostaglandin G/H synthase family. The encoded protein converts arachidonic acid to prostaglandin endoperoxide H2 which is a key enzymatic step in prostaglandin biosynthesis. This gene is the inducible prostaglandin G/H synthase family member that is upregulated during inflammation. Aberrant regulation of this gene is associated with cancer progression in several tissues and an increased risk of cardiovascular events. This gene is the target of many non-steroidal anti-inflammatory drugs.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AACTTT_UNKNOWN ,  CDP_02 ,  NFKB_Q6 ,  HNF1_C ,  NFKB_C ,  TACTTGA_MIR26A_MIR26B ,  GTACTGT_MIR101 ,  TTANTCA_UNKNOWN ,  WTGAAAT_UNKNOWN

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-26

miRNA binding sites
(Source: miRecords):

mmu-miR-101a Targeted Genes ,  mmu-miR-199a-3p Targeted Genes

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