QuickView for PTGS2;jsessionid=A605F6F6F559886484B5CEC598C76E51;jsessionid=0358D42125963F52A1F80A585042D6E1 (gene)
- Gene Symbol:
- Ptgs2
Rattus norvegicus - Full name:
- prostaglandin-endoperoxide synthase 2
- Synonyms:
- COX-2, Cox2, prostaglandin G/H synthase 2, PGH synthase 2, PGHS-2, PHS II, cyclooxygenase-2, prostaglandin H2 synthase 2
- Genomic Location:
- Chr 13: 64427166-64435401
- Description:
-
catalyzes the conversion of arachidonic acid products to prostaglandin; may play a role in response to endotoxic shock; may a role in long term potentiation
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Bos taurus , Gallus gallus , Canis lupus familiaris , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
cofactor binding | peroxidase activity | cation binding | antioxidant activity | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | enzyme binding | catalytic activity | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | identical protein binding | ion binding | organic cyclic compound binding | tetrapyrrole binding | protein binding | protein homodimerization activity | protein dimerization activity | prostaglandin-endoperoxide synthase activity | dioxygenase activity | heme binding | oxidoreductase activity, acting on peroxide as acceptor | metal ion binding | heterocyclic compound binding | oxidoreductase activity
GO Biological Process
positive regulation of smooth muscle cell proliferation | response to extracellular stimulus | molting cycle | regulation of blood vessel diameter | response to radiation | regulation of muscle system process | cellular response to decreased oxygen levels | positive regulation of locomotion | regulation of cysteine-type endopeptidase activity | regulation of intracellular protein transport | response to nutrient levels | positive regulation of blood circulation | response to ATP | response to cytokine | response to lipopolysaccharide | developmental process involved in reproduction | regulation of cellular localization | negative regulation of muscle contraction | positive regulation of apoptotic process | regulation of localization | regulation of programmed cell death | negative regulation of cysteine-type endopeptidase activity | response to hormone | cellular response to non-ionic osmotic stress | regulation of nitric oxide biosynthetic process | negative regulation of cellular process | positive regulation of developmental process | peroxidase activity | response to metal ion | regulation of protein import | cell differentiation | bone mineralization | maternal placenta development | defense response | cellular response to extracellular stimulus | regulation of smooth muscle contraction | response to fructose | response to drug | regulation of sprouting angiogenesis | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | negative regulation of proteolysis | blood vessel morphogenesis | response to organophosphorus | positive regulation of cellular biosynthetic process | cellular process | unsaturated fatty acid biosynthetic process | regulation of cell motility | cellular detoxification | positive regulation of synaptic transmission | antioxidant activity | negative regulation of signaling | positive regulation of peptidyl-serine phosphorylation | positive regulation of reactive oxygen species metabolic process | reproductive system development | response to estradiol | female pregnancy | multicellular organismal reproductive process | learning | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | regulation of response to osmotic stress | negative regulation of apoptotic process | response to hypoxia | regulation of proteolysis | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | brown fat cell differentiation | response to inorganic substance | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of fat cell differentiation | regulation of cell differentiation | gamete generation | positive regulation of vasoconstriction | positive regulation of unsaturated fatty acid biosynthetic process | negative regulation of apoptotic signaling pathway | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | negative regulation of synaptic transmission, dopaminergic | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | icosanoid biosynthetic process | cellular lipid metabolic process | cellular response to metal ion | positive regulation of epithelial cell migration | response to UV | regulation of vasculature development | response to stimulus | ovulation | vasculature development | female gamete generation | regulation of cellular protein localization | cellular response to mechanical stimulus | monocarboxylic acid metabolic process | regulation of fatty acid biosynthetic process | positive regulation of nitric oxide metabolic process | positive regulation of protein metabolic process | regulation of blood vessel size | cellular response to light stimulus | cellular response to hypoxia | response to stress | positive regulation of cellular protein localization | regulation of cell proliferation | cyclooxygenase pathway | positive regulation of lipid biosynthetic process | tube morphogenesis | regulation of blood circulation | response to peptide | positive regulation of synaptic plasticity | reproduction | cellular response to inorganic substance | positive regulation of vascular endothelial growth factor production | cardiovascular system development | response to temperature stimulus | positive regulation of sprouting angiogenesis | response to molecule of bacterial origin | cellular response to toxic substance | negative regulation of transport | positive regulation of blood vessel endothelial cell migration | cellular response to organic cyclic compound | regulation of protein transport | response to vitamin D | blood circulation | negative regulation of metabolic process | regulation of peptide transport | modulation of chemical synaptic transmission | cellular biosynthetic process | positive regulation of synaptic transmission, glutamatergic | regulation of intracellular transport | blood vessel development | regulation of fever generation | negative regulation of blood vessel diameter | negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress | regulation of cellular response to stress | regulation of neurotransmitter levels | response to nitrogen compound | positive regulation of reactive oxygen species biosynthetic process | response to light stimulus | regulation of platelet-derived growth factor production | response to external biotic stimulus | system development | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen | cellular response to nutrient levels | response to oxygen levels | reproductive process | regulation of signal transduction | multicellular organism development | negative regulation of catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | regulation of synaptic transmission, glutamatergic | regulation of peptidase activity | response to purine-containing compound | positive regulation of inflammatory response | learning or memory | response to fatty acid | regulation of muscle contraction | regulation of catalytic activity | lipid metabolic process | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | negative regulation of peptidase activity | regulation of acute inflammatory response | cellular response to ATP | cellular response to stress | response to lipid | nervous system process | regulation of blood pressure | positive regulation of intracellular protein transport | cellular response to heat | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular response to radiation | response to manganese ion | regulation of protein localization to nucleus | cellular response to oxygen levels | positive regulation of heat generation | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cysteine-type endopeptidase activity involved in apoptotic process | small molecule metabolic process | response to corticosteroid | cellular response to fluid shear stress | cellular response to lead ion | regulation of cellular component movement | response to nutrient | response to lithium ion | fat cell differentiation | response to oxidative stress | regulation of cell migration involved in sprouting angiogenesis | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of synaptic transmission, dopaminergic | regulation of fatty acid metabolic process | positive regulation of cell differentiation | regulation of endothelial cell migration | cognition | positive regulation of cell migration | fatty acid biosynthetic process | positive regulation of protein localization to nucleus | biosynthetic process | response to osmotic stress | sensory perception of pain | regulation of cellular protein metabolic process | angiogenesis | negative regulation of ion transport | lipid biosynthetic process | positive regulation of fatty acid biosynthetic process | response to toxic substance | positive regulation of brown fat cell differentiation | regulation of apoptotic signaling pathway | cellular response to UV | cellular response to drug | response to bacterium | cell communication | regulation of cellular metabolic process | positive regulation of smooth muscle contraction | positive regulation of fibroblast growth factor production | inflammatory response | negative regulation of calcium ion transport | regulation of protein metabolic process | positive regulation of cell proliferation | response to monosaccharide | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | regulation of tube size | positive regulation of transport | regulation of lipid biosynthetic process | regulation of prostaglandin biosynthetic process | long-chain fatty acid metabolic process | decidualization | carboxylic acid metabolic process | regulation of nucleocytoplasmic transport | response to angiotensin | multicellular organism reproduction | cytokine production | maternal process involved in female pregnancy | positive regulation of transforming growth factor beta production | cellular response to nutrient | regulation of establishment of protein localization | positive regulation of protein modification process | hair cycle | response to organic substance | regulation of protein import into nucleus | positive regulation of platelet-derived growth factor production | response to mechanical stimulus | cellular response to osmotic stress | positive regulation of fatty acid metabolic process | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | regulation of vasoconstriction | metabolic process | cellular oxidant detoxification | oxidation-reduction process | negative regulation of programmed cell death | regulation of tube diameter | prostaglandin-endoperoxide synthase activity | prostaglandin metabolic process | behavior | positive regulation of cell death | positive regulation of muscle contraction | organic substance metabolic process | negative regulation of intrinsic apoptotic signaling pathway | positive regulation of acute inflammatory response | response to vitamin | animal organ development | negative regulation of cellular protein metabolic process | regulation of fibroblast growth factor production | positive regulation of programmed cell death | dioxygenase activity | response to heat | regulation of phosphate metabolic process | biomineral tissue development | fatty acid metabolic process | positive regulation of cytokine production | positive regulation of intracellular transport | regulation of brown fat cell differentiation | positive regulation of endothelial cell migration | positive regulation of protein transport | regulation of reactive oxygen species biosynthetic process | regulation of peptidyl-serine phosphorylation | anatomical structure formation involved in morphogenesis | negative regulation of cell cycle | memory | negative regulation of protein metabolic process | sensory perception | regulation of epithelial cell migration | icosanoid metabolic process | response to fluid shear stress | positive regulation of fever generation | regulation of cell communication | regulation of blood vessel endothelial cell migration | maintenance of permeability of blood-brain barrier | negative regulation of molecular function | negative regulation of signal transduction | response to organic cyclic compound | positive regulation of prostaglandin biosynthetic process | positive regulation of cell migration involved in sprouting angiogenesis | organic acid metabolic process | positive regulation of phosphorylation | regulation of cytokine production | anatomical structure morphogenesis | regulation of endopeptidase activity | positive regulation of fat cell differentiation | positive regulation of protein import into nucleus | response to biotic stimulus | reproductive structure development | regulation of cellular ketone metabolic process | regulation of developmental process | regulation of ion transport | developmental process | positive regulation of protein import | regulation of calcium ion transport | tube development | regulation of transport | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | detoxification | response to organonitrogen compound | prostaglandin biosynthetic process | regulation of vascular endothelial growth factor production | response to lead ion | negative regulation of smooth muscle contraction | negative regulation of hydrolase activity | negative regulation of synaptic transmission | embryo implantation | positive regulation of nitric oxide biosynthetic process | oxidoreductase activity, acting on peroxide as acceptor | regulation of lipid metabolic process | positive regulation of metabolic process | ossification | regulation of synaptic plasticity | positive regulation of lipid metabolic process | cellular metabolic process | placenta development | response to tumor necrosis factor | cellular response to organic substance | regulation of protein localization | regulation of cell death | regulation of smooth muscle cell proliferation | positive regulation of cell motility | response to carbohydrate | oxidoreductase activity | response to steroid hormone | negative regulation of cell death | circulatory system development | regulation of inflammatory response | aging | arachidonic acid metabolic process | positive regulation of nucleocytoplasmic transport | sexual reproduction | positive regulation of angiogenesis | response to other organism | positive regulation of signaling | regulation of signaling | negative regulation of endopeptidase activity | response to glucocorticoid | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | neuron projection | organelle membrane | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | membrane microdomain | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | cell projection | endomembrane system | endoplasmic reticulum membrane | plasma membrane | membrane raft | membrane-bounded organelle | nucleus | organelle | cell periphery | plasma membrane raft | intracellular | caveola | membrane
