QuickView for PVT1;jsessionid=6DB9581B29E61C6D02494D89DC757037;jsessionid=1B2ABB8BE94B1C787874C051D4A087D1;jsessionid=959FC4BAF26FB60D188AB4382CBB8DCA;jsessionid=7524402B30338E5844B6550E8B90F4C0 (gene)

Gene Symbol:

PVT1 Homo sapiens

Full name:

Pvt1 oncogene (non-protein coding)

Synonyms:

LINC00079, MIR1204HG, MYC, NCRNA00079, onco-lncRNA-100, CXCR4/PVT1 fusion, HIST1H2BD/PVT1 fusion, MIR1204, MIR1205, MIR1206 and MIR1207 host, Oncogene PVT-1 (MYC activator), PVT1/CASC8 fusion, PVT1/CCDC26 fusion, PVT1/IFRD1 fusion, PVT1/IRF2BP2 fusion, PVT1/LINC00824 fusion, PVT1/MYC fusion, PVT1/NFIL3 fusion, PVT1/NSMCE2 fusion, PVT1/SPRY2 fusion, PVT1/UBB fusion, RP11-89K10/PVT1 fusion, long intergenic non-protein coding RNA 79, plasmacytoma variant translocation 1, pvt-1 (murine) oncogene homolog, MYC activator

Genomic Location:

Chr 8: 128875961-129182681

Description:

This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal d...

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This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis.

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Orthologs:

Mus musculus

External Links:

Entrez Gene

Cytogenetic Map:

8q24.21

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