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QuickView for Pirh2;jsessionid=1847FA74D41B4D34823BCB0C61FEEE9D;jsessionid=C017DE81B8F4C0A4596968C59613DF79 (gene)


Gene Symbol:
Rchy1 Mus musculus Mus musculus
Full name:
ring finger and CHY zinc finger domain containing 1
Synonyms:
ARNIP, CHIMP, Pirh2, Zfp363, Znf363, RING finger and CHY zinc finger domain-containing protein 1, CH-rich-interacting match with PLAG1, E3 ubiquitin-protein ligase Pirh2, RING-type E3 ubiquitin transferase RCHY1, androgen receptor N-terminal-interacting protein, zinc finger protein 363
Genomic Location:
Chr 5: 92377930-92392094
Description:
This gene encodes a protein containing CHY-, CTCHY-, and RING-type zinc-fingers. The encoded protein functions as an E3 ubiquitin ligase, and mediates the degradation of target proteins such as p53. The activity of this protein is important in cell cycle regulation. Alternative splicing results in multiple transcript variants.
Orthologs:
Homo sapiens Rattus norvegicus D. melanogaster Macaca mulatta Danio rerio Pan troglodytes Bos taurus Canis lupus familiaris Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:


Protein Names
Q9CR50
G3UWD8
Q920H0



GO Molecular Function

cation binding | signaling receptor binding | catalytic activity | ubiquitin-like protein transferase activity | p53 binding | identical protein binding | ion binding | protein binding | protein homodimerization activity | zinc ion binding | protein dimerization activity | ubiquitin-protein transferase activity | transferase activity | transition metal ion binding | metal ion binding

GO Biological Process

proteolysis | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | positive regulation of protein catabolic process | cellular process | organic substance catabolic process | proteolysis involved in cellular protein catabolic process | regulation of proteolysis | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of metabolic process | catabolic process | positive regulation of cellular protein metabolic process | positive regulation of cellular protein catabolic process | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | regulation of protein ubiquitination | positive regulation of proteolysis involved in cellular protein catabolic process | cellular protein catabolic process | positive regulation of proteolysis | protein modification process | macromolecule modification | nitrogen compound metabolic process | protein catabolic process | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of cellular protein metabolic process | positive regulation of proteasomal protein catabolic process | regulation of cellular metabolic process | regulation of protein metabolic process | regulation of proteasomal ubiquitin-dependent protein catabolic process | protein metabolic process | positive regulation of protein modification process | protein ubiquitination | cellular macromolecule catabolic process | protein autoubiquitination | metabolic process | positive regulation of ubiquitin-dependent protein catabolic process | ubiquitin-protein transferase activity | regulation of protein catabolic process | regulation of proteasomal protein catabolic process | organic substance metabolic process | protein modification by small protein conjugation or removal | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | cellular protein metabolic process | cellular protein modification process | positive regulation of metabolic process | cellular metabolic process | modification-dependent protein catabolic process | regulation of ubiquitin-dependent protein catabolic process | positive regulation of protein ubiquitination | macromolecule metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | cytoplasm | intracellular organelle | ubiquitin ligase complex | protein-containing complex | nucleoplasm | transferase complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular