QuickView for RNAPII;jsessionid=7BB27B6BEC1BCD5A324820F3706F9E7E;jsessionid=30C9E8C76DBACE99A4A94FB26557145B (gene)
- Gene Symbol:
- POLR2A
Homo sapiens - Full name:
- RNA polymerase II subunit A
- Synonyms:
- POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit, DNA-directed RNA polymerase II subunit A, DNA-directed RNA polymerase III largest subunit, RNA polymerase II subunit B1, RNA-directed RNA polymerase II subunit RPB1, polymerase (RNA) II (DNA directed) polypeptide A, 220kDa, polymerase (RNA) II subunit A
- Genomic Location:
- Chr 17: 7328422-7358653
- Description:
-
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in a...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Bos taurus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
HNF1_01 , E2F4DP1_01 , CIZ_01 , HNF1_C , GCCATNTTG_YY1_Q6 , WHN_B , GGGAGGRR_MAZ_Q6 , TGAYRTCA_ATF3_Q6 , E2F_Q6 , YY1_Q6
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
17p13.1
GO Molecular Function
cation binding | enzyme binding | nucleic acid binding | 5'-3' RNA polymerase activity | nucleotidyltransferase activity | catalytic activity | chromatin binding | ubiquitin-like protein ligase binding | DNA binding | promoter-specific chromatin binding | RNA-directed 5'-3' RNA polymerase activity | ion binding | organic cyclic compound binding | RNA polymerase II activity | protein binding | ubiquitin protein ligase binding | transferase activity, transferring phosphorus-containing groups | transferase activity | DNA-directed 5'-3' RNA polymerase activity | metal ion binding | heterocyclic compound binding | protein C-terminus binding | RNA binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | DNA-templated transcription, initiation | snRNA metabolic process | RNA processing | cellular process | 7-methylguanosine mRNA capping | response to growth factor | positive regulation of nitrogen compound metabolic process | snRNA transcription | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | regulation of gene silencing by miRNA | response to stimulus | RNA splicing | cellular response to fibroblast growth factor stimulus | response to stress | RNA splicing, via transesterification reactions | cellular nitrogen compound biosynthetic process | snRNA transcription by RNA polymerase II | positive regulation of RNA splicing | regulation of gene silencing | cellular nitrogen compound metabolic process | mRNA metabolic process | cellular biosynthetic process | DNA repair | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | cellular response to DNA damage stimulus | fibroblast growth factor receptor signaling pathway | ncRNA transcription | regulation of gene expression | cellular response to stress | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | RNA-directed 5'-3' RNA polymerase activity | biosynthetic process | aromatic compound biosynthetic process | transcription elongation from RNA polymerase II promoter | cell communication | regulation of cellular metabolic process | RNA polymerase II activity | regulation of RNA metabolic process | DNA-templated transcription, termination | response to organic substance | DNA metabolic process | cell surface receptor signaling pathway | metabolic process | nucleotide-excision repair | regulation of RNA splicing | regulation of RNA biosynthetic process | regulation of gene silencing by RNA | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | transcription, RNA-templated | transcription-coupled nucleotide-excision repair | signaling | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | 7-methylguanosine RNA capping | ncRNA metabolic process | response to fibroblast growth factor | heterocycle metabolic process | DNA-directed 5'-3' RNA polymerase activity | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | cellular metabolic process | mRNA processing | cellular response to organic substance | mRNA splicing, via spliceosome | signal transduction | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | DNA-templated transcription, elongation
GO Cellular Component
intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | nucleolus | Prp19 complex | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | transferase complex | membrane-bounded organelle | nucleus | organelle | nuclear DNA-directed RNA polymerase complex | RNA polymerase complex | membrane-enclosed lumen | RNA polymerase II, core complex | intracellular | RNA polymerase II, holoenzyme
