QuickView for Ruk;jsessionid=60A2608879B795D839DFB914C3532470;jsessionid=B8DA8B07E9142C795736F5548AE14275 (gene)

Gene Symbol:

SH3KBP1 Homo sapiens

Full name:

SH3 domain containing kinase binding protein 1

Synonyms:

CD2BP3, CIN85, GIG10, HSB-1, HSB1, MIG18, SH3 domain-containing kinase-binding protein 1, CD2-binding protein 3, SH3-domain kinase binding protein 1, Src family kinase-binding protein 1, c-Cbl-interacting protein, cbl-interacting protein of 85 kDa, human Src family kinase-binding protein 1, migration-inducing gene 18, src-related kinase binding protein-1

Genomic Location:

Chr X: 19463441-19815640

Description:

This gene encodes an adapter protein that contains one or more N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regul...

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This gene encodes an adapter protein that contains one or more N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  CMYB_01 ,  TAL1ALPHAE47_01 ,  RYTTCCTG_ETS2_B ,  VDR_Q3 ,  GATA3_01 ,  NKX3A_01 ,  NGFIC_01 ,  TACTTGA_MIR26A_MIR26B ,  NKX22_01 ,  ATGGYGGA_UNKNOWN ,  E2F1_Q4 ,  TAL1BETAE47_01 ,  GGGYGTGNY_UNKNOWN ,  CAGGTA_AREB6_01 ,  SP1_Q4_01 ,  EGR_Q6 ,  GCAAAAA_MIR129 ,  GGGCGGR_SP1_Q6 ,  USF_C ,  GTGCCAA_MIR96 ,  GCGNNANTTCC_UNKNOWN ,  RAAGNYNNCTTY_UNKNOWN ,  CTTTAAR_UNKNOWN ,  SP1_Q6 ,  GATA1_02 ,  RNGTGGGC_UNKNOWN ,  GTGCCTT_MIR506 ,  NMYC_01 ,  ATATGCA_MIR448 ,  SREBP_Q3 ,  TAL1BETAITF2_01 ,  EGR1_01 ,  KTGGYRSGAA_UNKNOWN ,  SMAD_Q6 ,  AACTTT_UNKNOWN ,  GGGNNTTTCC_NFKB_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-542-3p ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-410

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Cytogenetic Map:

Xp22.12

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