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QuickView for SLC12A1;jsessionid=F2BE1385D7823E0D630C0B12C0655AC9;jsessionid=ED5786F788E97A0F0AA02F6637CE37BF (gene)


Gene Symbol:
Slc12a1 Rattus norvegicus Rattus norvegicus
Full name:
solute carrier family 12 member 1
Synonyms:
BSC1, Nkcc2, solute carrier family 12 member 1, Solute carrier family 12, member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter), bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, kidney-specific Na-K-Cl symporter, solute carrier family 12 (sodium/potassium/chloride transporter), member 1, solute carrier family 12 (sodium/potassium/chloride transporters), member 1, solute carrier family 12 member 1, alternative spliced isoform
Genomic Location:
Chr 3: 112455828-112534738
Description:
has bumetamide-sensitive Na(+)-(K+)-Cl- symporter activity; may play a role in sodium and chloride transport in the kidney
Orthologs:
Homo sapiens Mus musculus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:





GO Molecular Function

anion transmembrane transporter activity | transmembrane transporter activity | potassium:chloride symporter activity | inorganic anion transmembrane transporter activity | symporter activity | chloride transmembrane transporter activity | sodium:potassium:chloride symporter activity | cation transmembrane transporter activity | active transmembrane transporter activity | transporter activity | ion transmembrane transporter activity | sodium:chloride symporter activity | metal ion transmembrane transporter activity | potassium ion transmembrane transporter activity | sodium ion transmembrane transporter activity | secondary active transmembrane transporter activity | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | cation:chloride symporter activity | solute:sodium symporter activity

GO Biological Process

hyperosmotic response | establishment of localization | anion transmembrane transporter activity | membrane organization | cellular process | localization | cellular homeostasis | regulation of calcium-mediated signaling | metal ion transport | anion transport | macromolecule localization | cellular hyperosmotic salinity response | regulation of cellular process | transmembrane transporter activity | cellular component organization | cellular lipid metabolic process | urogenital system development | chloride transmembrane transport | response to stimulus | response to salt stress | response to stress | chloride transport | potassium:chloride symporter activity | inorganic anion transport | cellular localization | regulation of cellular component size | kidney development | inorganic anion transmembrane transporter activity | symporter activity | metal ion homeostasis | system development | regulation of signal transduction | multicellular organism development | chloride transmembrane transporter activity | potassium ion import | lipid metabolic process | sodium:potassium:chloride symporter activity | ion transmembrane transport | protein localization to membrane | cellular response to stress | sodium ion transport | cation transmembrane transporter activity | excretion | monovalent inorganic cation transport | protein insertion into membrane from inner side | active transmembrane transporter activity | renal absorption | positive regulation of intracellular signal transduction | cellular potassium ion transport | ion transmembrane transporter activity | potassium ion transport | positive regulation of calcium-mediated signaling | response to osmotic stress | renal sodium ion transport | protein insertion into membrane | cation homeostasis | potassium ion homeostasis | positive regulation of signal transduction | homeostatic process | renal system development | sodium:chloride symporter activity | cellular hyperosmotic response | establishment of protein localization to membrane | cation transmembrane transport | metal ion transmembrane transporter activity | cellular response to osmotic stress | regulation of intracellular signal transduction | anion transmembrane transport | anatomical structure development | renal sodium ion absorption | potassium ion transmembrane transporter activity | metabolic process | cellular protein localization | chemical homeostasis | sodium ion transmembrane transport | organic substance metabolic process | animal organ development | diterpenoid metabolic process | regulation of calcineurin-NFAT signaling cascade | ion homeostasis | sodium ion transmembrane transporter activity | cellular response to salt stress | inorganic cation transmembrane transport | renal system process | secondary active transmembrane transporter activity | establishment of protein localization | positive regulation of calcineurin-NFAT signaling cascade | hyperosmotic salinity response | regulation of cell communication | transmembrane transport | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | protein localization | regulation of cell size | cation transport | cellular macromolecule localization | isoprenoid metabolic process | developmental process | potassium ion transmembrane transport | cation:chloride symporter activity | ion transport | cellular metabolic process | cell volume homeostasis | positive regulation of signaling | regulation of signaling | solute:sodium symporter activity | multicellular organismal process

GO Cellular Component

integral component of membrane | apical plasma membrane | cell | intrinsic component of membrane | apical part of cell | plasma membrane | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | cell surface | membrane