QuickView for SMAD4;jsessionid=C5E51A918123AAFC5914592879BA4459;jsessionid=4DBA6007DDB48AEF5F9F6597B64FCF12 (gene)
- Gene Symbol:
- Smad4
Rattus norvegicus - Full name:
- SMAD family member 4
- Synonyms:
- Madh4, mothers against decapentaplegic homolog 4, MAD (mothers against decapentaplegic Drosophila) homolog 4, MAD homolog 4, SMAD 4, mothers against DPP homolog 4
- Genomic Location:
- Chr 18: 70431585-70461613
- Description:
-
transduces signal from TGF-beta; deletion of human homolog gene is associated with pancreatic carcinomas
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , C. elegans , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
sequence-specific DNA binding | transcription factor activity, transcription factor binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | filamin binding | cation binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | protein-containing complex binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | chromatin binding | transforming growth factor beta receptor, common-partner cytoplasmic mediator activity | cytoskeletal protein binding | anion binding | collagen binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | sulfate binding | identical protein binding | protein heterodimerization activity | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | I-SMAD binding | protein binding | protein homodimerization activity | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transforming growth factor beta receptor, cytoplasmic mediator activity | transcription coregulator activity | SMAD binding | metal ion binding | heterocyclic compound binding | R-SMAD binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | limb development | regulation of supramolecular fiber organization | protein homooligomerization | SMAD protein signal transduction | cell morphogenesis | regulation of muscle system process | ventricular cardiac muscle tissue morphogenesis | negative regulation of cardiac myofibril assembly | transcription factor activity, transcription factor binding | positive regulation of macromolecule biosynthetic process | negative regulation of MAPK cascade | response to cytokine | cellular response to glucose stimulus | positive regulation of cellular component organization | left ventricular cardiac muscle tissue morphogenesis | neuron projection morphogenesis | developmental process involved in reproduction | muscle tissue development | interleukin-6-mediated signaling pathway | intracellular signal transduction | ovarian follicle development | atrioventricular valve formation | positive regulation of apoptotic process | regulation of cell development | regulation of localization | morphogenesis of an epithelium | gonad development | regulation of programmed cell death | regulation of cardiac muscle cell differentiation | female gonad development | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | pri-miRNA transcription by RNA polymerase II | negative regulation of RNA biosynthetic process | embryonic appendage morphogenesis | regulation of cardiac muscle cell apoptotic process | cell differentiation | endothelial cell differentiation | male gamete generation | nervous system development | epithelial to mesenchymal transition | negative regulation of protein phosphorylation | cellular chemical homeostasis | cell part morphogenesis | neurogenesis | glucose homeostasis | epithelial to mesenchymal transition involved in endocardial cushion formation | positive regulation of phosphate metabolic process | regulation of organelle organization | generation of neurons | mesenchyme development | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | negative regulation of muscle organ development | cellular homeostasis | cell projection morphogenesis | epithelial tube morphogenesis | limb morphogenesis | heart morphogenesis | negative regulation of signaling | developmental growth | neuron development | reproductive system development | positive regulation of epithelial to mesenchymal transition | mesoderm development | positive regulation of pathway-restricted SMAD protein phosphorylation | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | renal tubule morphogenesis | regulation of striated muscle tissue development | regulation of histone modification | branching involved in ureteric bud morphogenesis | response to hypoxia | axon guidance | response to growth factor | positive regulation of nitrogen compound metabolic process | positive regulation of muscle cell apoptotic process | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of histone H3-K9 acetylation | regulation of cell differentiation | gamete generation | muscle structure development | ventricular septum morphogenesis | negative regulation of muscle hypertrophy | regulation of cellular process | negative regulation of cardiocyte differentiation | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | cellular component organization | MAPK cascade | response to transforming growth factor beta | urogenital system development | nephron tubule morphogenesis | development of primary sexual characteristics | negative regulation of cardiac muscle tissue development | muscle organ morphogenesis | regulation of histone methylation | response to stimulus | cell morphogenesis involved in neuron differentiation | embryonic limb morphogenesis | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | negative regulation of striated muscle cell differentiation | somite rostral/caudal axis specification | regulation of SMAD protein signal transduction | response to stress | neuron projection guidance | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | roof of mouth development | tube morphogenesis | cardiac muscle tissue development | muscle tissue morphogenesis | response to glucose | development of primary female sexual characteristics | protein homotrimerization | reproduction | atrioventricular valve morphogenesis | cardiac ventricle morphogenesis | cellular nitrogen compound metabolic process | endothelial cell activation | positive regulation of hormone secretion | negative regulation of muscle tissue development | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of BMP signaling pathway | positive regulation of RNA biosynthetic process | cellular component assembly | endocardial cell differentiation | protein modification process | female gonad morphogenesis | cellular biosynthetic process | kidney development | embryo development | macromolecule modification | negative regulation of ERK1 and ERK2 cascade | metal ion homeostasis | anterior/posterior pattern specification | neuron fate commitment | regulation of nucleic acid-templated transcription | formation of anatomical boundary | locomotion | response to BMP | cellular response to interleukin-6 | endocardial cushion development | system development | brainstem development | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of organelle organization | endothelium development | ureteric bud development | negative regulation of growth | heart valve formation | negative regulation of phosphate metabolic process | regulation of actin cytoskeleton organization | multicellular organism development | cellular glucose homeostasis | regulation of MAPK cascade | regulation of BMP signaling pathway | phosphorus metabolic process | protein complex oligomerization | regulation of actomyosin structure organization | regulation of phosphorylation | kidney morphogenesis | nephrogenic mesenchyme morphogenesis | regulation of hormone levels | regulation of hormone secretion | wound healing | positive regulation of chromosome organization | cardiac epithelial to mesenchymal transition | seminiferous tubule development | regulation of gene expression | kidney epithelium development | axon development | positive regulation of secretion | outflow tract morphogenesis | endocardial cushion morphogenesis | embryonic axis specification | negative regulation of cardiac muscle cell differentiation | regulation of epidermis development | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | animal organ morphogenesis | positive regulation of luteinizing hormone secretion | negative regulation of cardiac muscle hypertrophy | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | cytokine-mediated signaling pathway | cardiocyte differentiation | regulation of hair follicle development | regulation of transcription by RNA polymerase II | axonogenesis | positive regulation of cell differentiation | stem cell differentiation | cellular response to cytokine stimulus | regulation of cell proliferation involved in heart morphogenesis | positive regulation of histone H3-K9 acetylation | cell proliferation | biosynthetic process | gonad morphogenesis | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | positive regulation of SMAD protein signal transduction | fertilization | mesenchyme morphogenesis | phosphorylation | mesonephric epithelium development | cardiac septum morphogenesis | cellular protein-containing complex assembly | metanephric mesenchyme morphogenesis | positive regulation of follicle-stimulating hormone secretion | positive regulation of cell proliferation involved in heart valve morphogenesis | skin development | endocrine system development | protein phosphorylation | cell morphogenesis involved in differentiation | mesonephros development | cation homeostasis | phosphate-containing compound metabolic process | gastrulation with mouth forming second | regulation of muscle cell apoptotic process | chordate embryonic development | striated muscle tissue development | cellular cation homeostasis | cardiac muscle tissue morphogenesis | cell communication | regulation of cellular metabolic process | positive regulation of histone H3-K4 methylation | transmembrane receptor protein serine/threonine kinase signaling pathway | protein trimerization | metanephros development | anterior/posterior axis specification | renal tubule development | regulation of endocrine process | regulation of protein metabolic process | positive regulation of signal transduction | regulation of histone H3-K4 methylation | negative regulation of striated muscle tissue development | heart development | homeostatic process | positive regulation of cell proliferation | response to monosaccharide | regulation of protein phosphorylation | embryo development ending in birth or egg hatching | iron ion homeostasis | regulation of RNA metabolic process | positive regulation of protein acetylation | renal system development | positive regulation of transport | negative regulation of cell growth | regulation of cellular response to growth factor stimulus | regulation of cell proliferation involved in heart valve morphogenesis | single fertilization | embryonic morphogenesis | nephron development | cellular response to transforming growth factor beta stimulus | secondary palate development | neuron differentiation | multicellular organism reproduction | protein-containing complex assembly | development of primary male sexual characteristics | ureteric bud morphogenesis | heart valve development | ventricular septum development | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | regulation of cardiac muscle hypertrophy | DNA-binding transcription factor activity | regionalization | cardiac ventricle development | axis specification | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | regulation of cardiac muscle tissue development | SMAD protein complex assembly | tissue morphogenesis | branching morphogenesis of an epithelial tube | endocardium development | male sex differentiation | response to wounding | regulation of animal organ morphogenesis | regulation of intracellular signal transduction | positive regulation of peptidyl-lysine acetylation | negative regulation of intracellular signal transduction | ventricular cardiac muscle tissue development | anatomical structure development | cell surface receptor signaling pathway | cell projection organization | metabolic process | cell fate commitment | mesenchymal cell differentiation | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | male gonad development | negative regulation of cytoskeleton organization | adrenal gland development | cellular response to carbohydrate stimulus | chemical homeostasis | regulation of secretion | positive regulation of cell death | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | neuron projection development | atrioventricular canal development | heart valve morphogenesis | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | nephron morphogenesis | animal organ development | positive regulation of histone modification | negative regulation of cellular protein metabolic process | gene expression | positive regulation of programmed cell death | ion homeostasis | regulation of heart morphogenesis | regulation of striated muscle cell differentiation | regulation of phosphate metabolic process | regulation of chromosome organization | regulation of transforming growth factor beta2 production | cellular iron ion homeostasis | atrioventricular valve development | transcription, DNA-templated | nephrogenic mesenchyme development | cell activation | morphogenesis of a branching epithelium | transforming growth factor beta receptor signaling pathway | anatomical structure formation involved in morphogenesis | uterus development | positive regulation of cardiac muscle cell apoptotic process | negative regulation of protein catabolic process | negative regulation of protein metabolic process | positive regulation of transforming growth factor beta receptor signaling pathway | BMP signaling pathway | positive regulation of cell proliferation involved in heart morphogenesis | regulation of cell communication | negative regulation of signal transduction | signaling | somite development | regulation of transcription, DNA-templated | cell development | embryonic digit morphogenesis | positive regulation of phosphorylation | cellular protein metabolic process | regulation of follicle-stimulating hormone secretion | regulation of cytokine production | endocardial cushion formation | endoderm development | morphogenesis of a branching structure | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | reproductive structure development | regulation of developmental process | segmentation | developmental process | regulation of muscle cell differentiation | regulation of cell growth | spermatogenesis | cardiac septum development | cellular protein modification process | regulation of histone acetylation | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of histone acetylation | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | regulation of hair cycle | metanephric mesenchyme development | positive regulation of nucleic acid-templated transcription | neural crest cell differentiation | transcription coregulator activity | cellular metal ion homeostasis | epithelial cell differentiation | ERK1 and ERK2 cascade | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | negative regulation of supramolecular fiber organization | cardiac chamber development | heterocycle metabolic process | somitogenesis | negative regulation of muscle cell differentiation | in utero embryonic development | positive regulation of metabolic process | regulation of actin filament-based process | ossification | cellular response to BMP stimulus | osteoblast differentiation | transition metal ion homeostasis | positive regulation of histone methylation | gastrulation | cellular metabolic process | sebaceous gland development | female sex differentiation | cellular response to organic substance | regulation of cell death | sex differentiation | response to carbohydrate | regulation of organelle assembly | response to interleukin-6 | negative regulation of cell death | negative regulation of cell development | circulatory system development | aging | carbohydrate homeostasis | chemotaxis | sexual reproduction | nephron tubule development | negative regulation of cell differentiation | regulation of cellular component organization | muscle organ development | regulation of cytoskeleton organization | positive regulation of signaling | cardiac left ventricle morphogenesis | signal transduction | regulation of signaling | mesonephric tubule development | regulation of pathway-restricted SMAD protein phosphorylation | positive regulation of gene expression | embryonic pattern specification | outflow tract septum morphogenesis | cellular response to growth factor stimulus | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process | regulation of chromatin organization | regulation of phosphorus metabolic process
GO Cellular Component
nuclear transcription factor complex | activin responsive factor complex | chromosome | intracellular membrane-bounded organelle | microtubule organizing center | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | SMAD protein complex | cytoplasm | intracellular organelle | centrosome | protein-containing complex | nucleoplasm | chromatin | nuclear chromosome | microtubule cytoskeleton | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | cytosol | cytoskeleton | intracellular
