QuickView for SMURF1;jsessionid=9E0DC5D4AB61EBF70FE81FEE65C6D5AB;jsessionid=5AB48331A578C54CF6DAD031A7094F92;jsessionid=613CEA963E6EDCC4E023E7270F6C839F (gene)
- Gene Symbol:
- Smurf1
Rattus norvegicus - Full name:
- SMAD specific E3 ubiquitin protein ligase 1
- Synonyms:
- RGD1309707, E3 ubiquitin-protein ligase SMURF1
- Genomic Location:
- Chr 12: 9950108-10042398
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Bos taurus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-125 , Predicted Gene Targets for miR-138 , Predicted Gene Targets for miR-15 , Predicted Gene Targets for miR-153 , Predicted Gene Targets for miR-194 , Predicted Gene Targets for miR-25 , Predicted Gene Targets for miR-448 , Predicted Gene Targets for miR-503 , Predicted Gene Targets for miR-203 , Predicted Gene Targets for miR-490
GO Molecular Function
catalytic activity | ubiquitin-like protein transferase activity | ubiquitin protein ligase activity | I-SMAD binding | protein binding | ubiquitin-protein transferase activity | transferase activity | ubiquitin-like protein ligase activity | SMAD binding | R-SMAD binding
GO Biological Process
positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of neurogenesis | nuclear export | proteolysis | regulation of cell development | protein localization to vacuole | macroautophagy | engulfment of target by autophagosome | establishment of localization | regulation of autophagy | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of BMP signaling pathway | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | nervous system development | positive regulation of protein catabolic process | neurogenesis | regulation of organelle organization | generation of neurons | membrane organization | intracellular transport | cellular process | organic substance catabolic process | localization | proteolysis involved in cellular protein catabolic process | protein transport | negative regulation of signaling | parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization | macromolecule localization | regulation of proteolysis | response to growth factor | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | establishment of localization in cell | regulation of cell differentiation | regulation of cellular process | positive regulation of cell growth | regulation of metabolic process | catabolic process | positive regulation of cellular protein metabolic process | cellular component organization | protein export from nucleus | positive regulation of autophagy of mitochondrion | positive regulation of cellular protein catabolic process | response to stimulus | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | response to stress | intracellular protein transport | vacuolar transport | regulation of dendrite extension | positive regulation of proteolysis involved in cellular protein catabolic process | cellular protein catabolic process | cellular localization | positive regulation of proteolysis | proteasomal protein catabolic process | positive regulation of mitophagy in response to mitochondrial depolarization | regulation of macroautophagy | regulation of cellular component size | cellular component assembly | regulation of axon extension | protein modification process | macromolecule modification | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | positive regulation of mitochondrion organization | protein targeting to vacuole | regulation of nucleic acid-templated transcription | negative regulation of cellular response to transforming growth factor beta stimulus | response to BMP | organelle assembly | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | autophagosome organization | positive regulation of neuron projection development | multicellular organism development | regulation of BMP signaling pathway | regulation of axonogenesis | regulation of ossification | regulation of neuron differentiation | regulation of gene expression | organic substance transport | cellular response to stress | protein catabolic process | positive regulation of cellular metabolic process | positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | enzyme linked receptor protein signaling pathway | positive regulation of cell projection organization | peptide transport | negative regulation of cellular response to growth factor stimulus | regulation of transcription by RNA polymerase II | ubiquitin protein ligase activity | protein localization to organelle | positive regulation of cell differentiation | regulation of cellular protein metabolic process | protein localization to cell surface | vacuole organization | autophagy | regulation of mitochondrion organization | cell communication | regulation of cellular metabolic process | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of protein metabolic process | regulation of RNA metabolic process | regulation of cellular response to growth factor stimulus | proteasome-mediated ubiquitin-dependent protein catabolic process | regulation of autophagy of mitochondrion | protein polyubiquitination | ubiquitin-dependent SMAD protein catabolic process | regulation of cell morphogenesis involved in differentiation | protein metabolic process | negative regulation of transforming growth factor beta receptor signaling pathway | regulation of growth | response to organic substance | receptor catabolic process | protein ubiquitination | autophagosome assembly | negative regulation of ossification | cellular macromolecule catabolic process | establishment of protein localization to organelle | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | metabolic process | positive regulation of cell development | positive regulation of ubiquitin-dependent protein catabolic process | ubiquitin-protein transferase activity | regulation of protein catabolic process | regulation of RNA biosynthetic process | cellular protein localization | membrane invagination | amide transport | organic substance metabolic process | nuclear transport | protein modification by small protein conjugation or removal | establishment of protein localization to vacuole | positive regulation of autophagy | establishment of protein localization | positive regulation of macroautophagy | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | BMP signaling pathway | regulation of cell communication | response to mitochondrial depolarisation | negative regulation of signal transduction | positive regulation of developmental growth | signaling | positive regulation of growth | regulation of transcription, DNA-templated | regulation of developmental growth | protein localization | cellular protein metabolic process | regulation of cell size | cellular macromolecule localization | nucleocytoplasmic transport | regulation of nervous system development | regulation of developmental process | developmental process | organelle organization | positive regulation of mitophagy | substrate localization to autophagosome | regulation of cell growth | cellular protein modification process | protein targeting to vacuole involved in autophagy | receptor metabolic process | positive regulation of dendrite extension | positive regulation of metabolic process | positive regulation of neuron differentiation | cellular response to BMP stimulus | protein targeting | regulation of cell projection organization | cellular metabolic process | cellular response to organic substance | modification-dependent protein catabolic process | regulation of ubiquitin-dependent protein catabolic process | regulation of cellular component organization | signal transduction | regulation of signaling | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | neuron projection | somatodendritic compartment | cell body | cell | neuronal cell body | cytoplasm | intracellular organelle | cell projection | plasma membrane | mitochondrion | membrane-bounded organelle | organelle | cell periphery | axon | intracellular | membrane
