QuickView for Sec4;jsessionid=B2BBCE91E97F64AF3250FC60E845CB9A;jsessionid=A7FF784ACC360403DA21007C06BFF3E8 (gene)

Gene Symbol:

RAB8A Homo sapiens

Full name:

RAB8A, member RAS oncogene family

Synonyms:

MEL, RAB8, ras-related protein Rab-8A, mel transforming oncogene (RAB8 homolog), mel transforming oncogene (derived from cell line NK14), mel transforming oncogene (derived from cell line NK14)- RAB8 homolog, oncogene c-mel, ras-associated protein RAB8

Genomic Location:

Chr 19: 16083490-16105445

Description:

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% s...

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The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Bos taurus ,  Schizosaccharomyces pombe ,  Canis lupus familiaris ,  Gallus gallus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MCAATNNNNNGCG_UNKNOWN ,  AGCYRWTTC_UNKNOWN ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  TCTGATC_MIR383 ,  GGGYGTGNY_UNKNOWN ,  ACCAAAG_MIR9 ,  GGGCGGR_SP1_Q6 ,  GGCNRNWCTTYS_UNKNOWN ,  SCGGAAGY_ELK1_02 ,  TGACAGNY_MEIS1_01 ,  AAGCACA_MIR218

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-383 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-137

Cytogenetic Map:

19p13.11

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