QuickView for Shh;jsessionid=ECF24D4399EB277671063C6694F82A61;jsessionid=E70B6607A311FFD3FEF0E66BB923213A (gene)
- Gene Symbol:
- SHH
Gallus gallus - Full name:
- sonic hedgehog homolog (Drosophila)
- Synonyms:
- N/A
- Genomic Location:
- Chr 2: 8024867-8034924
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Bos taurus , Danio rerio , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
patched binding | cation binding | signaling receptor binding | hydrolase activity | carbohydrate derivative binding | molecular function regulator | catalytic activity | extracellular matrix binding | laminin-1 binding | ion binding | laminin binding | protein binding | zinc ion binding | receptor regulator activity | receptor ligand activity | glycosaminoglycan binding | transition metal ion binding | calcium ion binding | metal ion binding | peptidase activity | morphogen activity
GO Biological Process
negative regulation of lymphocyte differentiation | negative regulation of leukocyte activation | positive regulation of skeletal muscle cell proliferation | brain development | limb development | positive regulation of striated muscle cell differentiation | cell morphogenesis | positive regulation of macromolecule biosynthetic process | intein-mediated protein splicing | regulation of intracellular protein transport | negative regulation of immune system process | growth plate cartilage chondrocyte differentiation | cell motility | regulation of neurogenesis | chondrocyte development | neuron projection morphogenesis | positive regulation of kidney smooth muscle cell differentiation | tracheoesophageal septum formation | developmental process involved in reproduction | regulation of cellular localization | muscle tissue development | intracellular signal transduction | regulation of cholesterol transport | positive regulation of skeletal muscle tissue development | floor plate morphogenesis | proteolysis | regulation of cell development | homeostasis of number of cells within a tissue | regulation of localization | prostate gland growth | regulation of epithelial cell proliferation involved in prostate gland development | morphogenesis of an epithelium | cell proliferation involved in kidney development | positive regulation of DNA-binding transcription factor activity | positive regulation of striated muscle tissue development | positive regulation of embryonic development | intermediate filament organization | regulation of programmed cell death | foregut morphogenesis | T cell lineage commitment | cell proliferation in external granule layer | eye development | cell proliferation involved in metanephros development | branching involved in salivary gland morphogenesis | establishment of localization | spinal cord motor neuron differentiation | regulation of immune system process | negative regulation of BMP signaling pathway | regulation of immature T cell proliferation in thymus | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | neural tube patterning | positive regulation of developmental process | embryonic camera-type eye morphogenesis | protein processing | negative regulation of RNA biosynthetic process | embryonic appendage morphogenesis | response to metal ion | positive regulation of lymphocyte activation | bone development | regulation of protein import | cell differentiation | positive regulation of epithelial cell proliferation | regulation of T cell differentiation | respiratory tube development | hindgut development | nervous system development | organ growth | determination of left/right asymmetry in lateral mesoderm | cell part morphogenesis | endochondral bone morphogenesis | neurogenesis | positive regulation of cell adhesion | generation of neurons | mesenchyme development | tissue homeostasis | telencephalon regionalization | salivary gland morphogenesis | regulation of neuroblast proliferation | regulation of lipid transport | negative regulation of proteolysis | negative T cell selection | blood vessel morphogenesis | positive regulation of T cell differentiation | pattern specification process | primary prostatic bud elongation | positive regulation of cellular biosynthetic process | cellular process | positive regulation of T cell differentiation in thymus | cell fate specification | lymphocyte differentiation | positive regulation of mesenchymal cell proliferation involved in ureter development | regulation of cell motility | localization | cell projection morphogenesis | epithelial tube morphogenesis | negative regulation of ubiquitin-dependent protein catabolic process | limb morphogenesis | commissural neuron axon guidance | lymphoid progenitor cell differentiation | heart morphogenesis | negative regulation of signaling | developmental growth | regulation of dopaminergic neuron differentiation | neuron development | left lung development | central nervous system neuron differentiation | determination of left/right symmetry | reproductive system development | canonical Wnt signaling pathway | mesoderm development | optic cup morphogenesis involved in camera-type eye development | regulation of embryonic development | immune system development | hindgut morphogenesis | regulation of skeletal muscle cell proliferation | negative regulation of nucleic acid-templated transcription | renal tubule morphogenesis | regulation of striated muscle tissue development | negative regulation of alpha-beta T cell differentiation | macromolecule localization | hemostasis | negative regulation of apoptotic process | branching involved in ureteric bud morphogenesis | digestive tract morphogenesis | axon guidance | dorsal/ventral axis specification | regulation of proteolysis | osteoblast development | lung epithelium development | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment | negative regulation of T cell proliferation | positive regulation of cell division | growth plate cartilage development | diencephalon development | response to inorganic substance | regulation of canonical Wnt signaling pathway | regulation of smoothened signaling pathway | regulation of mesenchymal cell proliferation involved in prostate gland development | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | positive regulation of muscle cell differentiation | muscle structure development | anatomical structure homeostasis | muscle cell differentiation | hindlimb morphogenesis | negative regulation of cell motility | growth plate cartilage chondrocyte development | regulation of cellular process | leukocyte activation | regulation of apoptotic process | positive regulation of sclerotome development | regulation of metabolic process | gliogenesis | negative regulation of mononuclear cell proliferation | cranial nerve morphogenesis | organic cyclic compound metabolic process | epithelium development | negative thymic T cell selection | establishment of cell polarity | cellular component organization | prostate gland epithelium morphogenesis | epithelial tube branching involved in lung morphogenesis | mesenchymal smoothened signaling pathway involved in prostate gland development | cellular response to metal ion | regulation of cell division | urogenital system development | negative regulation of cellular protein catabolic process | T cell activation | nephron tubule morphogenesis | head development | cranial nerve development | thyroid gland development | branching involved in blood vessel morphogenesis | response to stimulus | cellular response to lithium ion | thymus development | vasculature development | cell morphogenesis involved in neuron differentiation | lung lobe morphogenesis | regulation of cellular protein localization | mesenchymal cell development | embryonic limb morphogenesis | respiratory system development | signal transduction downstream of smoothened | regulation of neural retina development | oligodendrocyte development | positive regulation of immune system process | regulation of cellular protein catabolic process | negative regulation of cell adhesion | determination of heart left/right asymmetry | gland morphogenesis | response to stress | neuron projection guidance | negative regulation of lymphocyte activation | smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation | positive regulation of cellular protein localization | positive regulation of lymphocyte proliferation | spinal cord dorsal/ventral patterning | regulation of cell proliferation | negative regulation of DNA-templated transcription, elongation | roof of mouth development | multicellular organismal homeostasis | positive regulation of neuroblast proliferation | tube morphogenesis | polarity specification of anterior/posterior axis | positive regulation of cell-cell adhesion | protein localization to nucleus | hematopoietic progenitor cell differentiation | programmed cell death | forebrain regionalization | cartilage development involved in endochondral bone morphogenesis | supramolecular fiber organization | positive regulation of cell activation | reproduction | cellular response to inorganic substance | cellular localization | embryonic skeletal system development | cardiovascular system development | embryonic digestive tract morphogenesis | androgen metabolic process | midbrain development | regulation of cell differentiation involved in tissue homeostasis | axis elongation | positive regulation of T cell activation | negative regulation of transport | positive regulation of gliogenesis | negative regulation of muscle tissue development | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | negative regulation of hemopoiesis | regulation of odontogenesis | cartilage development | regulation of peptide transport | regulation of cell adhesion | dorsal/ventral pattern formation | kidney development | embryo development | regulation of morphogenesis of a branching structure | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | cell-cell signaling | protein splicing | regulation of oligodendrocyte differentiation | trachea morphogenesis | regulation of intracellular transport | molecular function regulator | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of lymphocyte differentiation | fibroblast growth factor production | blood vessel development | anterior/posterior pattern specification | neuron fate commitment | blood coagulation | regulation of nucleic acid-templated transcription | leukocyte differentiation | formation of anatomical boundary | chondrocyte differentiation involved in endochondral bone morphogenesis | locomotion | apoptotic process | positive regulation of mononuclear cell proliferation | regulation of skeletal muscle tissue development | negative regulation of cholesterol efflux | optic cup formation involved in camera-type eye development | system development | ventral spinal cord development | chondrocyte differentiation | regulation of retina development in camera-type eye | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | ureteric bud development | Wnt signaling pathway | multicellular organism development | cell migration | positive regulation of lymphocyte differentiation | thalamus development | neuroblast proliferation | regulation of BMP signaling pathway | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | positive regulation of muscle organ development | lipid metabolic process | kidney morphogenesis | regulation of hormone levels | retina morphogenesis in camera-type eye | embryonic digestive tract development | wound healing | regulation of T cell activation | telencephalon development | artery development | negative regulation of transcription elongation from RNA polymerase II promoter | determination of bilateral symmetry | positive regulation of alpha-beta T cell differentiation | regulation of neuron differentiation | regulation of gene expression | stem cell proliferation | forelimb morphogenesis | salivary gland cavitation | kidney epithelium development | pancreas development | axon development | positive thymic T cell selection | self proteolysis | response to lipid | cerebellar granule cell precursor proliferation | branching involved in prostate gland morphogenesis | positive regulation of intracellular protein transport | regulation of stem cell proliferation | embryonic heart tube morphogenesis | optic nerve development | positive regulation of cellular metabolic process | epithelial-mesenchymal cell signaling | regulation of lymphocyte activation | floor plate formation | regulation of smooth muscle cell differentiation | animal organ morphogenesis | regulation of protein localization to nucleus | limb bud formation | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | regulation of cell migration | embryonic forelimb morphogenesis | lateral mesoderm development | bone growth | negative regulation of cellular response to growth factor stimulus | cell fate specification involved in pattern specification | vesicle-mediated transport | regulation of cellular component movement | regulation of transcription by RNA polymerase II | response to lithium ion | positive regulation of smooth muscle cell differentiation | axonogenesis | protein localization to organelle | positive regulation of cell differentiation | homeostasis of number of cells | stem cell differentiation | negative regulation of smooth muscle cell differentiation | embryonic camera-type eye development | cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation | cell proliferation | positive regulation of protein localization to nucleus | neural tube development | regulation of cellular protein metabolic process | positive regulation of T cell proliferation | glial cell differentiation | angiogenesis | hindbrain development | regulation of transcription elongation from RNA polymerase II promoter | positive regulation of epithelial cell proliferation involved in prostate gland development | mesonephric epithelium development | digestive tract development | positive regulation of hh target transcription factor activity | heart looping | protein maturation | regulation of apoptosis involved in tissue homeostasis | skin development | positive regulation of neural retina development | endocrine system development | cell morphogenesis involved in differentiation | mesonephros development | establishment or maintenance of cell polarity | sensory organ development | neural crest cell migration | chondroblast differentiation | negative regulation of cell-cell adhesion | chordate embryonic development | animal organ formation | striated muscle tissue development | cell communication | regulation of cellular metabolic process | eye morphogenesis | skeletal system morphogenesis | metanephros development | anterior/posterior axis specification | renal tubule development | regulation of alpha-beta T cell differentiation | negative regulation of cell activation | astrocyte differentiation | regulation of protein metabolic process | dorsal/ventral neural tube patterning | positive regulation of signal transduction | vasculogenesis | inner ear development | cell proliferation in hindbrain | heart development | homeostatic process | positive regulation of cell proliferation | positive regulation of establishment of protein localization | bone morphogenesis | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | renal system development | positive regulation of transport | genitalia development | response to retinoic acid | chondrocyte hypertrophy | cell fate commitment involved in pattern specification | striated muscle cell differentiation | regulation of cellular response to growth factor stimulus | coagulation | apoptotic signaling pathway | embryonic hindlimb morphogenesis | embryonic morphogenesis | bud outgrowth involved in lung branching | negative regulation of T cell differentiation | nephron development | lymphocyte activation | positive regulation of molecular function | regulation of nucleocytoplasmic transport | regulation of proteasomal ubiquitin-dependent protein catabolic process | specification of axis polarity | neuron differentiation | cytokine production | embryonic organ morphogenesis | T cell differentiation | polarity specification of dorsal/ventral axis | regulation of signaling receptor activity | negative regulation of lipid transport | receptor regulator activity | ureteric bud morphogenesis | protein metabolic process | regulation of establishment of protein localization | regionalization | axis specification | T cell selection | response to organic substance | gland development | T cell differentiation in thymus | tissue morphogenesis | regulation of protein import into nucleus | digestive system development | regulation of hemopoiesis | regulation of prostatic bud formation | branching morphogenesis of an epithelial tube | retina development in camera-type eye | epithelial cell proliferation | male sex differentiation | response to wounding | positive regulation of immature T cell proliferation | regulation of animal organ morphogenesis | import into cell | ventral midline development | regulation of DNA-binding transcription factor activity | embryonic heart tube development | anatomical structure development | developmental growth involved in morphogenesis | branch elongation of an epithelium | cell surface receptor signaling pathway | positive regulation of neurogenesis | regulation of neural precursor cell proliferation | cell projection organization | metabolic process | positive regulation of cell development | cell fate commitment | positive regulation of smoothened signaling pathway | mesenchymal cell differentiation | regulation of protein catabolic process | epithelial-mesenchymal signaling involved in prostate gland development | negative regulation of leukocyte proliferation | regulation of RNA biosynthetic process | prostate epithelial cord elongation | positive regulation of leukocyte activation | regulation of body fluid levels | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | embryonic organ development | regulation of proteasomal protein catabolic process | cellular protein localization | positive T cell selection | ear development | oligodendrocyte differentiation | positive regulation of glial cell differentiation | intermediate filament-based process | spinal cord patterning | endocytosis | trachea development | morphogenesis of embryonic epithelium | receptor ligand activity | male genitalia development | negative regulation of mesenchymal cell apoptotic process | optic nerve morphogenesis | neuron projection development | embryonic camera-type eye formation | thymic T cell selection | mesenchymal cell proliferation | organic substance metabolic process | connective tissue development | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | nephron morphogenesis | animal organ development | lung-associated mesenchyme development | forebrain development | negative regulation of neuron differentiation | nerve development | negative regulation of cellular protein metabolic process | gene expression | regulation of cell activation | negative regulation of cellular component movement | retina homeostasis | regulation of Wnt signaling pathway | neural precursor cell proliferation | regulation of striated muscle cell differentiation | cytoskeleton organization | prostate gland morphogenesis | negative regulation of dopaminergic neuron differentiation | Bergmann glial cell differentiation | positive regulation of muscle tissue development | regulation of DNA-templated transcription, elongation | ectoderm development | positive regulation of intracellular transport | negative regulation of cholesterol transport | cell activation | lung development | stem cell development | morphogenesis of a branching epithelium | positive regulation of protein transport | camera-type eye development | smoothened signaling pathway | anatomical structure formation involved in morphogenesis | negative regulation of protein catabolic process | negative regulation of protein metabolic process | cell differentiation in spinal cord | regulation of animal organ formation | steroid metabolic process | regulation of glial cell differentiation | regulation of cell communication | regulation of gliogenesis | chondrocyte development involved in endochondral bone morphogenesis | negative regulation of signal transduction | negative regulation of ureter smooth muscle cell differentiation | signaling | somite development | regulation of transcription, DNA-templated | glial cell development | myotube differentiation | myoblast differentiation | cell development | embryonic digit morphogenesis | regulation of T cell proliferation | protein localization | regulation of epithelial cell proliferation | regulation of T cell differentiation in thymus | hormone metabolic process | floor plate development | morphogenesis of a branching structure | anatomical structure morphogenesis | prostate gland development | cellular macromolecule localization | positive regulation of stem cell proliferation | camera-type eye morphogenesis | positive regulation of protein import into nucleus | right lung development | regulation of cerebellar granule cell precursor proliferation | reproductive structure development | positive regulation of ureter smooth muscle cell differentiation | regulation of nervous system development | regulation of developmental process | regulation of cholesterol efflux | positive regulation of neural precursor cell proliferation | epithelial cell proliferation involved in salivary gland morphogenesis | regulation of mesenchymal cell proliferation | developmental process | negative regulation of canonical Wnt signaling pathway | organelle organization | regulation of muscle cell differentiation | positive regulation of alpha-beta T cell activation | positive regulation of protein import | negative regulation of alpha-beta T cell activation | negative regulation of kidney smooth muscle cell differentiation | positive regulation of oligodendrocyte differentiation | negative regulation of transcription by RNA polymerase II | tube development | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | intermediate filament cytoskeleton organization | regulation of cell-cell adhesion | mesenchymal cell proliferation involved in lung development | metanephric mesenchyme development | developmental cell growth | positive regulation of mesenchymal cell proliferation | positive regulation of kidney development | positive regulation of nucleic acid-templated transcription | cell fate determination | embryonic retina morphogenesis in camera-type eye | neural crest cell differentiation | lung morphogenesis | positive regulation of transcription by RNA polymerase II | tube formation | central nervous system development | negative regulation of muscle cell differentiation | spinal cord development | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | ossification | osteoblast differentiation | growth plate cartilage chondrocyte growth | positive regulation of cerebellar granule cell precursor proliferation | skeletal system development | negative regulation of lymphocyte proliferation | immune system process | positive regulation of Wnt signaling pathway | lung lobe development | embryonic foregut morphogenesis | cellular metabolic process | hematopoietic or lymphoid organ development | embryonic eye morphogenesis | peptidase activity | ameboidal-type cell migration | regulation of protein localization | exocrine system development | regulation of cell death | sex differentiation | salivary gland development | retinal pigment epithelium development | homeostasis of number of retina cells | morphogen activity | negative regulation of cell death | negative regulation of cell development | circulatory system development | regulation of ubiquitin-dependent protein catabolic process | chemotaxis | endochondral bone growth | negative regulation of proteolysis involved in cellular protein catabolic process | negative regulation of locomotion | positive regulation of nucleocytoplasmic transport | neural crest cell development | positive regulation of leukocyte cell-cell adhesion | nephron tubule development | positive regulation of immature T cell proliferation in thymus | negative regulation of cell differentiation | positive regulation of signaling | metanephric mesenchymal cell proliferation involved in metanephros development | signal transduction | regulation of signaling | mesonephric tubule development | positive regulation of gene expression | embryonic pattern specification | regulation of muscle organ development | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process | negative regulation of proteasomal protein catabolic process
GO Cellular Component
extracellular matrix | cell | membrane microdomain | plasma membrane | membrane raft | extracellular region | extracellular space | cell periphery | cell surface | intracellular | membrane
