QuickView for Smo;jsessionid=D4105C4D0D68F57DC4925BB7E71ED046;jsessionid=DB73CED05843CE49AC9A165CF4577E71 (gene)
- Gene Symbol:
- Smo
Mus musculus - Full name:
- smoothened, frizzled class receptor
- Synonyms:
- E130215L21Rik, Smoh, bnb, smoothened, smoothened homolog, bent body
- Genomic Location:
- Chr 6: 29685503-29711359
- Orthologs:
- Homo sapiens , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
patched binding | transmembrane signaling receptor activity | signaling receptor binding | signaling receptor activity | protein binding | Wnt-activated receptor activity | drug binding | Wnt-protein binding
GO Biological Process
brain development | molting cycle | cell morphogenesis | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of intracellular protein transport | detection of stimulus | epidermis morphogenesis | myoblast migration | cell motility | regulation of neurogenesis | neuron projection morphogenesis | regulation of cellular localization | muscle tissue development | intracellular signal transduction | regulation of cell development | protein stabilization | homeostasis of number of cells within a tissue | regulation of localization | morphogenesis of an epithelium | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | hippocampus development | forebrain morphogenesis | negative regulation of hair follicle development | astrocyte development | negative regulation of neuron death | negative regulation of cellular process | neural tube patterning | positive regulation of developmental process | negative regulation of RNA biosynthetic process | regulation of protein import | cell differentiation | positive regulation of epithelial cell proliferation | striated muscle cell development | nervous system development | multicellular organism growth | type B pancreatic cell differentiation | left/right pattern formation | cerebellum morphogenesis | determination of left/right asymmetry in lateral mesoderm | cell part morphogenesis | neurogenesis | positive regulation of cellular component movement | generation of neurons | mesenchyme development | tissue homeostasis | regulation of neuroblast proliferation | cardiac atrium morphogenesis | blood vessel morphogenesis | pattern specification process | regulation of neuron death | neuron projection extension | positive regulation of cellular biosynthetic process | cellular process | cell fate specification | axon extension involved in axon guidance | regulation of cell motility | localization | cell projection morphogenesis | epithelial tube morphogenesis | mesenchymal to epithelial transition involved in metanephric renal vesicle formation | commissural neuron axon guidance | odontogenesis | heart morphogenesis | type B pancreatic cell development | developmental growth | myotube cell development | neuron development | central nervous system neuron differentiation | determination of left/right symmetry | canonical Wnt signaling pathway | mesoderm development | contact inhibition | negative regulation of nucleic acid-templated transcription | macromolecule localization | glandular epithelial cell differentiation | negative regulation of apoptotic process | axon guidance | regulation of multicellular organism growth | positive regulation of nitrogen compound metabolic process | diencephalon development | regulation of smoothened signaling pathway | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of cell differentiation | metanephric nephron development | muscle structure development | anatomical structure homeostasis | muscle cell differentiation | skeletal muscle organ development | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | gliogenesis | metanephric nephron morphogenesis | epithelium development | endocrine pancreas development | cellular component organization | urogenital system development | head development | response to stimulus | detection of cell density by contact stimulus involved in contact inhibition | vasculature development | muscle cell development | cell morphogenesis involved in neuron differentiation | regulation of cellular protein localization | mesenchymal cell development | midgut development | signal transduction downstream of smoothened | metencephalon development | determination of heart left/right asymmetry | renal vesicle formation | neuron projection guidance | smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation | positive regulation of cellular protein localization | skeletal muscle tissue development | spinal cord dorsal/ventral patterning | regulation of cell proliferation | multicellular organismal homeostasis | positive regulation of neuroblast proliferation | tube morphogenesis | protein localization to nucleus | epithelial cell development | regulation of epithelial cell differentiation | regulation of smooth muscle cell migration | cellular localization | response to alcohol | cardiovascular system development | regulation of stem cell population maintenance | regulation of DNA binding | cellular response to organic cyclic compound | metanephros morphogenesis | regulation of protein transport | brain morphogenesis | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | regulation of peptide transport | left/right axis specification | dorsal/ventral pattern formation | kidney development | positive regulation of multicellular organism growth | embryo development | regulation of morphogenesis of a branching structure | cell-cell signaling | muscle fiber development | regulation of intracellular transport | cell surface receptor signaling pathway involved in cell-cell signaling | blood vessel development | anterior/posterior pattern specification | positive regulation of vascular associated smooth muscle cell migration | regulation of nucleic acid-templated transcription | locomotion | negative regulation of neuron apoptotic process | system development | enteroendocrine cell differentiation | regulation of signal transduction | Wnt signaling pathway | regulation of protein stability | ventral midline determination | astrocyte activation | multicellular organism development | cell migration | thalamus development | mammary gland development | positive regulation of smooth muscle cell migration | cellular response to cholesterol | cerebellum development | kidney morphogenesis | hair follicle morphogenesis | telencephalon development | determination of bilateral symmetry | regulation of gene expression | kidney epithelium development | pancreas development | axon development | negative regulation of hair cycle | response to lipid | regulation of epidermis development | positive regulation of intracellular protein transport | regulation of stem cell proliferation | embryonic heart tube morphogenesis | positive regulation of cellular metabolic process | cellular response to sterol | epithelial-mesenchymal cell signaling | animal organ morphogenesis | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | regulation of cell migration | lateral mesoderm development | response to cholesterol | cardiac atrium development | negative regulation of DNA binding | regulation of hair follicle development | regulation of cellular component movement | regulation of transcription by RNA polymerase II | axonogenesis | protein localization to organelle | negative regulation of binding | positive regulation of cell differentiation | non-canonical Wnt signaling pathway | homeostasis of number of cells | stem cell differentiation | renal vesicle morphogenesis | positive regulation of cell migration | cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation | positive regulation of protein localization to nucleus | neural tube development | cell differentiation involved in kidney development | glial cell differentiation | hindbrain development | cardiac septum morphogenesis | digestive tract development | positive regulation of hh target transcription factor activity | glandular epithelial cell development | mesenchymal to epithelial transition involved in metanephros morphogenesis | heart looping | epidermis development | skin development | endocrine system development | cell morphogenesis involved in differentiation | mesenchymal to epithelial transition | neural crest cell migration | chordate embryonic development | striated muscle tissue development | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | metanephros development | cell differentiation involved in metanephros development | odontogenesis of dentin-containing tooth | astrocyte differentiation | dentate gyrus development | cerebellar cortex morphogenesis | dorsal/ventral neural tube patterning | positive regulation of signal transduction | vasculogenesis | heart development | homeostatic process | limbic system development | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | renal system development | positive regulation of transport | cerebral cortex development | striated muscle cell differentiation | embryonic morphogenesis | negative regulation of epithelial cell differentiation | nephron development | positive regulation of molecular function | regulation of nucleocytoplasmic transport | pancreas morphogenesis | neuron differentiation | embryonic organ morphogenesis | positive regulation of organ growth | muscle cell migration | regulation of establishment of protein localization | regionalization | axis specification | regulation of growth | hair cycle | response to organic substance | gland development | tissue morphogenesis | regulation of protein import into nucleus | digestive system development | regulation of animal organ morphogenesis | axon extension | ventral midline development | regulation of DNA-binding transcription factor activity | embryonic heart tube development | anatomical structure development | developmental growth involved in morphogenesis | cell surface receptor signaling pathway | positive regulation of neurogenesis | metanephric renal vesicle morphogenesis | regulation of neural precursor cell proliferation | cell projection organization | positive regulation of cell development | cell fate commitment | positive regulation of smoothened signaling pathway | mesenchymal cell differentiation | positive regulation of branching involved in ureteric bud morphogenesis | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | embryonic organ development | cellular protein localization | cerebellar cortex development | spinal cord patterning | hindbrain morphogenesis | hair cycle process | neuron projection development | negative regulation of biosynthetic process | negative regulation of gene expression | nephron morphogenesis | animal organ development | forebrain development | pallium development | regulation of heart morphogenesis | skin epidermis development | mammary gland epithelium development | positive regulation of intracellular transport | cell activation | atrial septum development | stem cell development | positive regulation of protein transport | smoothened signaling pathway | anatomical structure formation involved in morphogenesis | regulation of cell communication | Wnt-activated receptor activity | negative regulation of molecular function | positive regulation of developmental growth | signaling | somite development | positive regulation of growth | regulation of transcription, DNA-templated | glial cell development | myotube differentiation | response to organic cyclic compound | smoothened signaling pathway involved in ventral spinal cord patterning | cell development | regulation of developmental growth | protein localization | regulation of epithelial cell proliferation | anatomical structure morphogenesis | cellular macromolecule localization | positive regulation of stem cell proliferation | positive regulation of protein import into nucleus | regulation of organ growth | regulation of cerebellar granule cell precursor proliferation | response to biotic stimulus | regulation of nervous system development | regulation of developmental process | positive regulation of neural precursor cell proliferation | detection of biotic stimulus | renal vesicle development | regulation of mesenchymal cell proliferation | developmental process | positive regulation of protein import | cardiac septum development | columnar/cuboidal epithelial cell development | negative regulation of transcription by RNA polymerase II | tube development | regulation of transport | positive regulation of transcription, DNA-templated | regulation of hair cycle | atrial septum morphogenesis | developmental cell growth | positive regulation of mesenchymal cell proliferation | positive regulation of kidney development | positive regulation of nucleic acid-templated transcription | neural crest cell differentiation | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | cardiac chamber development | mammary gland epithelial cell differentiation | regulation of branching involved in ureteric bud morphogenesis | central nervous system development | spinal cord development | in utero embryonic development | positive regulation of metabolic process | ossification | osteoblast differentiation | positive regulation of cerebellar granule cell precursor proliferation | ameboidal-type cell migration | cellular response to organic substance | regulation of protein localization | regulation of cell death | positive regulation of cell motility | negative regulation of cell death | circulatory system development | chemotaxis | positive regulation of nucleocytoplasmic transport | neural crest cell development | negative regulation of cell differentiation | muscle organ development | positive regulation of signaling | hair follicle development | signal transduction | regulation of signaling | positive regulation of gene expression | skeletal muscle fiber development | multicellular organismal process
GO Cellular Component
dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | ciliary membrane | somatodendritic compartment | organelle membrane | cell projection membrane | cell body | cell | neuronal cell body | distal axon | dendrite terminus | cytoplasm | intracellular organelle | membrane microdomain | dendritic tree | Golgi apparatus | cell projection | endomembrane system | postsynapse | plasma membrane | cilium | membrane raft | postsynaptic density | asymmetric synapse | site of polarized growth | axonal growth cone | membrane-bounded organelle | nucleus | organelle | postsynaptic specialization | cell periphery | axon | growth cone | plasma membrane raft | dendritic growth cone | intracellular | caveola | membrane
