QuickView for SvC;jsessionid=6B759D1B3CED789039EEE0F2ABE1973C;jsessionid=EAF192A3351D4A2EEFBD4894F3C69AFB (gene)

Gene Symbol:

COL4A1 Homo sapiens

Full name:

collagen type IV alpha 1 chain

Synonyms:

BSVD, RATOR, collagen alpha-1(IV) chain, COL4A1 NC1 domain, arresten, collagen IV, alpha-1 polypeptide, collagen of basement membrane, alpha-1 chain

Genomic Location:

Chr 13: 109599311-109757497

Description:

This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous d...

View Full Description

This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

IRF1_01 ,  AML1_01 ,  TGCCTTA_MIR124A ,  GTGCCTT_MIR506 ,  AML1_Q6 ,  ICSBP_Q6 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  COREBINDINGFACTOR_Q6 ,  STTTCRNTTT_IRF_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-410

miRNA binding sites
(Source: miRecords):

hsa-miR-29c Targeted Genes

Cytogenetic Map:

13q34

search → result