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QuickView for THRA;jsessionid=5D65BA3F5C03824A2AE987DA29A833DF;jsessionid=9BA5DCB17D8F0DB4780012990A6AE7A0 (gene)


Gene Symbol:
Thra Rattus norvegicus Rattus norvegicus
Full name:
thyroid hormone receptor alpha
Synonyms:
ERBA1, Thra1, c-erbA-1, thyroid hormone receptor alpha, c-erbAalpha2, C-erbA-alpha, avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1, c-erb-A thyroid hormone receptor, c-erbA-alpha2, nuclear receptor subfamily 1 group A member 1, thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1)
Genomic Location:
Chr 10: 87514443-87542306
Description:
binds the promoter of the Na+/H+ exchanger NHE1 and mediates thyroid hormone induced transcriptional activation
Orthologs:
Homo sapiens Mus musculus Macaca mulatta Danio rerio Gallus gallus Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
E47_01 E47_02 CDPCR1_01 CEBPA_01 CEBPB_02 PBX1_02 OCT1_01 OCT1_02 OCT1_04 PAX5_01
miRNA binding sites
(Source: TargetScan):


Transcripts Names
NM_001017960
NM_031134
Protein Names
P63059
G3V764



GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nuclear receptor activity | cation binding | transcription factor activity, direct ligand regulated sequence-specific DNA binding | nucleic acid binding | protein-containing complex binding | steroid hormone receptor activity | chromatin binding | protein domain specific binding | single-stranded RNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | signaling receptor activity | sequence-specific double-stranded DNA binding | thyroid hormone binding | identical protein binding | protein heterodimerization activity | ion binding | organic cyclic compound binding | hormone binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | protein binding | protein homodimerization activity | zinc ion binding | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | chromatin DNA binding | TBP-class protein binding | intronic transcription regulatory region DNA binding | protein dimerization activity | nuclear receptor transcription coactivator activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | transition metal ion binding | transcription coregulator activity | steroid receptor RNA activator RNA binding | metal ion binding | heterocyclic compound binding | thyroid hormone receptor activity | RNA binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly | response to extracellular stimulus | brain development | positive regulation of striated muscle cell differentiation | positive regulation of macromolecule biosynthetic process | response to nutrient levels | positive regulation of female receptivity | regulation of programmed cell death | erythrocyte homeostasis | response to hormone | myeloid cell differentiation | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cell differentiation | respiratory tube development | type I pneumocyte differentiation | nervous system development | response to drug | hormone-mediated signaling pathway | positive regulation of cellular biosynthetic process | regulation of transcription initiation from RNA polymerase II promoter | cellular process | nuclear receptor activity | localization | immune system development | transcription factor activity, direct ligand regulated sequence-specific DNA binding | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | macromolecule localization | lung epithelium development | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | positive regulation of muscle cell differentiation | regulation of myotube differentiation | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | regulation of protein complex assembly | hepaticobiliary system development | organic cyclic compound metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | urogenital system development | head development | thyroid gland development | response to stimulus | cartilage condensation | respiratory system development | female mating behavior | response to cold | response to stress | cellular nitrogen compound biosynthetic process | regulation of blood circulation | regulation of female receptivity | reproduction | response to temperature stimulus | negative regulation of DNA-templated transcription, initiation | cellular nitrogen compound metabolic process | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | steroid hormone receptor activity | steroid hormone mediated signaling pathway | cartilage development | regulation of thyroid hormone mediated signaling pathway | cellular biosynthetic process | kidney development | embryo development | myeloid cell homeostasis | regulation of nucleic acid-templated transcription | cellular response to hormone stimulus | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | multicellular organism development | learning or memory | regulation of gene expression | response to lipid | nervous system process | positive regulation of cellular metabolic process | animal organ morphogenesis | liver development | regulation of nitrogen compound metabolic process | cytoplasmic sequestering of protein | negative regulation of DNA-binding transcription factor activity | regulation of transcription by RNA polymerase II | positive regulation of cell differentiation | cognition | homeostasis of number of cells | biosynthetic process | aromatic compound biosynthetic process | cytoplasmic sequestering of transcription factor | regulation of RNA polymerase II transcriptional preinitiation complex assembly | digestive tract development | female courtship behavior | regulation of heart contraction | endocrine system development | maintenance of protein location | cell communication | regulation of cellular metabolic process | skeletal system morphogenesis | regulation of lipid catabolic process | homeostatic process | transcription coactivator activity | regulation of RNA metabolic process | renal system development | lung epithelial cell differentiation | multicellular organism reproduction | DNA-binding transcription factor activity | courtship behavior | response to organic substance | gland development | digestive system development | regulation of DNA-binding transcription factor activity | anatomical structure development | reproductive behavior | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nuclear receptor transcription coactivator activity | embryonic organ development | mating behavior | adrenal gland development | behavior | regulation of myeloid cell apoptotic process | nucleobase-containing compound metabolic process | negative regulation of protein complex assembly | organic substance metabolic process | mating | connective tissue development | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | regulation of striated muscle cell differentiation | cellular response to steroid hormone stimulus | transcription, DNA-templated | lung development | intracellular receptor signaling pathway | negative regulation of transcription initiation from RNA polymerase II promoter | regulation of cell communication | negative regulation of molecular function | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | protein localization | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of DNA-templated transcription, initiation | regulation of developmental process | developmental process | regulation of muscle cell differentiation | erythrocyte differentiation | lung cell differentiation | cell aggregation | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | central nervous system development | regulation of lipid metabolic process | positive regulation of metabolic process | ossification | skeletal system development | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of cell death | response to steroid hormone | sexual reproduction | thyroid hormone receptor activity | regulation of cellular component organization | positive regulation of myotube differentiation | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

nuclear transcription factor complex | intracellular membrane-bounded organelle | RNA polymerase II transcription factor complex | cell | transcription factor complex | cytoplasm | intracellular organelle | protein-containing complex | mitochondrion | membrane-bounded organelle | nucleus | organelle | cytosol | intracellular