QuickView for TIMD3;jsessionid=0E4688471605F71823183DC1ED8D4A04;jsessionid=8FC8C90776CF091A3AB8FDC2F436182E;jsessionid=8EE0E250E5E8B2CF3946F2991F5C97F3 (gene)
- Gene Symbol:
- HAVCR2
Homo sapiens - Full name:
- hepatitis A virus cellular receptor 2
- Synonyms:
- CD366, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3, hepatitis A virus cellular receptor 2, T cell immunoglobulin mucin 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin family member 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, kidney injury molecule-3
- Genomic Location:
- Chr 5: 156445421-156468716
- Description:
-
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity react...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
5q33.3
GO Molecular Function
cation binding | ion binding | protein binding | metal ion binding
GO Biological Process
positive regulation of immune response | negative regulation of leukocyte activation | regulation of ERK1 and ERK2 cascade | adaptive immune response | negative regulation of immune system process | negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target | immune response-regulating signaling pathway | response to lipopolysaccharide | negative regulation of type I interferon production | regulation of myeloid dendritic cell activation | regulation of localization | defense response to other organism | regulation of immune system process | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | positive regulation of lymphocyte activation | defense response | regulation of leukocyte mediated cytotoxicity | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of protein secretion | innate immune response-activating signal transduction | cellular process | toll-like receptor signaling pathway | positive regulation of macrophage activation | female pregnancy | tolerance induction | immune system development | multicellular organismal reproductive process | negative regulation of innate immune response | positive regulation of nitrogen compound metabolic process | negative regulation of T cell proliferation | toll-like receptor 7 signaling pathway | negative regulation of immune response to tumor cell | regulation of immune response | regulation of cellular process | leukocyte activation | cellular response to lipid | regulation of metabolic process | negative regulation of mononuclear cell proliferation | cellular response to molecule of bacterial origin | positive regulation of interferon-gamma production | negative regulation of tumor necrosis factor production | positive regulation of cellular protein metabolic process | regulation of natural killer cell activation | positive regulation of interleukin-4 production | positive regulation of tumor necrosis factor production | regulation of peptide secretion | regulation of type I interferon production | response to stimulus | positive regulation of NIK/NF-kappaB signaling | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of protein metabolic process | negative regulation of cell adhesion | response to stress | negative regulation of tumor necrosis factor superfamily cytokine production | negative regulation of lymphocyte activation | leukocyte activation involved in immune response | positive regulation of lymphocyte proliferation | regulation of cell proliferation | negative regulation of interferon-gamma production | positive regulation of cell-cell adhesion | positive regulation of cell activation | activation of innate immune response | reproduction | positive regulation of cytokine secretion | response to molecule of bacterial origin | positive regulation of T cell activation | immune response-activating signal transduction | regulation of protein transport | negative regulation of metabolic process | regulation of peptide transport | regulation of cell adhesion | negative regulation of adaptive immune response | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | negative regulation of interleukin-3 production | negative regulation of NF-kappaB transcription factor activity | regulation of tolerance induction dependent upon immune response | positive regulation of mononuclear cell proliferation | response to external biotic stimulus | system development | regulation of interleukin-4 production | reproductive process | regulation of signal transduction | pattern recognition receptor signaling pathway | negative regulation of interleukin-6 production | multicellular organism development | positive regulation of tumor necrosis factor secretion | negative regulation of immunological synapse formation | regulation of MAPK cascade | regulation of phosphorylation | regulation of T cell activation | negative regulation of natural killer cell mediated cytotoxicity | regulation of gene expression | positive regulation of secretion | response to lipid | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | regulation of tolerance induction | regulation of defense response to bacterium | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | negative regulation of DNA-binding transcription factor activity | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | macrophage activation involved in immune response | regulation of cellular protein metabolic process | negative regulation of T-helper 1 type immune response | positive regulation of T cell proliferation | negative regulation of immune response | positive regulation of chemokine production | regulation of tumor necrosis factor production | regulation of macrophage activation | response to bacterium | regulation of interleukin-1 production | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | positive regulation of interleukin-1 production | regulation of macrophage colony-stimulating factor production | negative regulation of cell activation | inflammatory response | cell activation involved in immune response | regulation of NIK/NF-kappaB signaling | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | negative regulation of interleukin-2 production | defense response to bacterium | positive regulation of cell proliferation | negative regulation of natural killer cell activation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of RNA metabolic process | positive regulation of defense response to bacterium | positive regulation of transport | regulation of cytokine secretion | multicellular organism reproduction | maternal process involved in female pregnancy | toll-like receptor 9 signaling pathway | activation of immune response | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | regulation of adaptive immune response | negative regulation of leukocyte proliferation | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | regulation of secretion | macrophage activation | immune response | negative regulation of gene expression | regulation of cell activation | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | regulation of tumor necrosis factor secretion | negative regulation of interferon-alpha production | regulation of phosphate metabolic process | negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell | positive regulation of cytokine production | cell activation | positive regulation of MAPK cascade | regulation of natural killer cell mediated cytotoxicity | positive regulation of protein transport | toll-like receptor 3 signaling pathway | negative regulation of granulocyte colony-stimulating factor production | defense response to Gram-positive bacterium | regulation of cell communication | negative regulation of molecular function | signaling | regulation of transcription, DNA-templated | regulation of T cell proliferation | positive regulation of phosphorylation | regulation of cytokine production | response to biotic stimulus | regulation of developmental process | developmental process | negative regulation of defense response to bacterium | regulation of chemokine production | regulation of transport | negative regulation of cell proliferation | regulation of cell-cell adhesion | innate immune response | positive regulation of metabolic process | negative regulation of myeloid dendritic cell activation | regulation of interferon-gamma production | negative regulation of lymphocyte proliferation | immune system process | regulation of natural killer cell mediated immunity | cellular response to organic substance | regulation of protein localization | regulation of interleukin-6 production | natural killer cell tolerance induction | positive regulation of leukocyte cell-cell adhesion | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | cellular response to lipopolysaccharide | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | immunological synapse | cytoplasmic vesicle | cell | nuclear lumen | intrinsic component of membrane | cytoplasm | intracellular organelle | protein-containing complex | endomembrane system | nucleoplasm | plasma membrane | vesicle | mediator complex | endosome | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | early endosome | intracellular vesicle | cell surface | intracellular | cell junction | membrane
