QuickView for TNF;jsessionid=7D7090D16B1CB0C4297AC6FE2A378DCD;jsessionid=61B02F289A6BBA75783C54BC41E5A81A (gene)
- Gene Symbol:
- Tnf
Mus musculus - Full name:
- tumor necrosis factor
- Synonyms:
- DIF, TNF-a, TNF-alpha, TNFSF2, TNFalpha, Tnfa, Tnfsf1a, Tnlg1f, tumor necrosis factor, cachectin, tumor necrosis factor ligand 1f, tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
- Genomic Location:
- Chr 17: 35336335-35338941
- Description:
-
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological ...
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Bos taurus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
AACTTT_UNKNOWN , CETS1P54_01 , NFKAPPAB_01 , CEBPB_01 , HNF3B_01 , CEBP_01 , HFH3_01 , HFH8_01 , FOXJ2_01 , HNF6_Q6
- miRNA binding sites
(Source: miRecords):
GO Molecular Function
transcription regulatory region DNA binding | enzyme binding | nucleic acid binding | signaling receptor binding | cytokine receptor binding | molecular function regulator | DNA binding | identical protein binding | organic cyclic compound binding | tumor necrosis factor receptor binding | protein binding | receptor regulator activity | receptor ligand activity | cytokine activity | protease binding | tumor necrosis factor receptor superfamily binding | heterocyclic compound binding
GO Biological Process
positive regulation of immune response | regulation of JUN kinase activity | positive regulation of smooth muscle cell proliferation | positive regulation of action potential | positive regulation of hormone biosynthetic process | regulation of extrinsic apoptotic signaling pathway in absence of ligand | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | regulation of cysteine-type endopeptidase activity | regulation of dephosphorylation | response to virus | positive regulation of leukocyte adhesion to vascular endothelial cell | negative regulation of immune system process | actin filament-based process | detection of stimulus | extracellular structure organization | response to cytokine | regulation of cellular response to oxidative stress | positive regulation of cellular component organization | regulation of response to oxidative stress | cell motility | immune response-regulating signaling pathway | response to lipopolysaccharide | protein localization to cell periphery | regulation of cellular localization | negative regulation of peptide secretion | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell development | regulation of localization | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | negative regulation of protein complex disassembly | defense response to other organism | actin cytoskeleton organization | necroptotic process | epithelial cell apoptotic process | establishment of localization | regulation of immune system process | response to hormone | myeloid cell differentiation | lipid storage | regulation of nitric oxide biosynthetic process | negative regulation of branching involved in lung morphogenesis | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | regulation of phosphatase activity | negative regulation of RNA biosynthetic process | glucose metabolic process | cellular response to tumor necrosis factor | cell differentiation | regulation of vitamin metabolic process | negative regulation of growth of symbiont involved in interaction with host | detection of mechanical stimulus involved in sensory perception | defense response | intrinsic apoptotic signaling pathway in response to DNA damage | positive regulation of protein catabolic process | response to drug | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | negative regulation of protein secretion | regulation of organelle organization | regulation of peptide hormone secretion | positive regulation of protein secretion | sensory perception of mechanical stimulus | salivary gland morphogenesis | intracellular transport | positive regulation of vascular smooth muscle cell proliferation | regulation of neuron death | necroptotic signaling pathway | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | regulation of immunoglobulin secretion | cellular process | toll-like receptor signaling pathway | regulation of glucose import | regulation of cytokine biosynthetic process | localization | regulation of removal of superoxide radicals | extrinsic apoptotic signaling pathway | positive regulation of synaptic transmission | regulation of calcium-mediated signaling | protein transport | positive regulation of humoral immune response mediated by circulating immunoglobulin | negative regulation of signaling | positive regulation of immune effector process | positive regulation of peptidyl-serine phosphorylation | regulation of branching involved in salivary gland morphogenesis | positive regulation of reactive oxygen species metabolic process | positive regulation of adaptive immune response | positive regulation of heterotypic cell-cell adhesion | regulation of mitotic nuclear division | programmed necrotic cell death | negative regulation of viral life cycle | immune system development | negative regulation of nucleic acid-templated transcription | positive regulation of protein kinase activity | negative regulation of amino acid transport | macromolecule localization | negative regulation of apoptotic process | negative regulation of secretion | positive regulation of oxidoreductase activity | regulation of proteolysis | negative regulation of alkaline phosphatase activity | regulation of cell cycle | positive regulation of catalytic activity | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | regulation of myosin-light-chain-phosphatase activity | negative regulation of L-glutamate import across plasma membrane | establishment of localization in cell | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | regulation of myeloid leukocyte differentiation | regulation of neurological system process | regulation of cell differentiation | negative regulation of neurotransmitter transport | intrinsic apoptotic signaling pathway | negative regulation of apoptotic signaling pathway | positive regulation of blood microparticle formation | positive regulation of interleukin-8 production | regulation of protein kinase B signaling | regulation of immune response | regulation of cellular process | regulation of osteoblast differentiation | regulation of apoptotic process | cellular response to lipid | leukocyte tethering or rolling | regulation of metabolic process | negative regulation of cytokine secretion | positive regulation of stress-activated MAPK cascade | regulation of protein complex assembly | regulation of bicellular tight junction assembly | cortical actin cytoskeleton organization | positive regulation of protein complex disassembly | cellular response to molecule of bacterial origin | protein import into nucleus | positive regulation of interferon-gamma production | positive regulation of translation | positive regulation of cellular protein metabolic process | negative regulation of phosphatase activity | positive regulation of hair cycle | positive regulation of chronic inflammatory response to antigenic stimulus | cellular response to organonitrogen compound | negative regulation of response to drug | cellular component organization | MAPK cascade | regulation of translational initiation | regulation of peptide secretion | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | negative regulation of protein transport | positive regulation of NIK/NF-kappaB signaling | regulation of cellular protein localization | JNK cascade | positive regulation of innate immune response | positive regulation of osteoclast differentiation | positive regulation of nitric oxide metabolic process | regulation of insulin secretion | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of peptidase activity | signal transduction by protein phosphorylation | gland morphogenesis | negative regulation of neurological system process | response to stress | intracellular protein transport | regulation of heterotypic cell-cell adhesion | positive regulation of chemokine biosynthetic process | positive regulation of cellular protein localization | positive regulation of membrane protein ectodomain proteolysis | regulation of response to drug | posttranscriptional regulation of gene expression | regulation of cell proliferation | positive regulation of lipid biosynthetic process | activation of MAPKKK activity | negative regulation of glucose transmembrane transport | regulation of chemokine (C-X-C motif) ligand 2 production | positive regulation of cell-cell adhesion | protein localization to nucleus | regulation of humoral immune response mediated by circulating immunoglobulin | positive regulation of cysteine-type endopeptidase activity | regulation of epithelial cell differentiation | regulation of humoral immune response | inflammatory response to antigenic stimulus | programmed cell death | positive regulation of cytokine biosynthetic process | activation of innate immune response | positive regulation of interleukin-18 production | cellular localization | positive regulation of cytokine secretion | regulation of neurotransmitter uptake | positive regulation of proteolysis | response to molecule of bacterial origin | cellular response to toxic substance | immune response-activating signal transduction | negative regulation of viral genome replication | extracellular matrix organization | negative regulation of transport | extrinsic apoptotic signaling pathway via death domain receptors | cellular response to organic cyclic compound | regulation of calcidiol 1-monooxygenase activity | regulation of phagocytosis | regulation of protein transport | positive regulation of vitamin D biosynthetic process | negative regulation of metabolic process | regulation of superoxide dismutase activity | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | hemopoiesis | protein modification process | positive regulation of hair follicle development | regulation of peptide transport | modulation of chemical synaptic transmission | positive regulation of response to oxidative stress | regulation of cell adhesion | regulation of steroid biosynthetic process | regulation of morphogenesis of a branching structure | macromolecule modification | regulation of steroid metabolic process | negative regulation of transmembrane transport | activation of protein kinase activity | molecular function regulator | receptor biosynthetic process | stress-activated protein kinase signaling cascade | regulation of fever generation | leukocyte migration | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | regulation of membrane potential | leukocyte differentiation | regulation of cellular response to stress | detection of abiotic stimulus | regulation of neurotransmitter levels | positive regulation of monooxygenase activity | locomotion | response to nitrogen compound | negative regulation of osteoblast differentiation | apoptotic process | protein kinase B signaling | positive regulation of reactive oxygen species biosynthetic process | response to nicotine | regulation of superoxide metabolic process | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | pattern recognition receptor signaling pathway | negative regulation of secretion by cell | regulation of interleukin-8 biosynthetic process | negative regulation of growth | negative regulation of phosphate metabolic process | negative regulation of interleukin-6 production | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of peptidase activity | regulation of MAPK cascade | phosphorus metabolic process | response to amino acid | positive regulation of organelle assembly | positive regulation of inflammatory response | negative regulation of lipid catabolic process | protein import into nucleus, translocation | cellular response to DNA damage stimulus | positive regulation of podosome assembly | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of protein localization to cell surface | negative regulation of glucose import | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | regulation of ossification | regulation of protein complex disassembly | regulation of acute inflammatory response | protein localization to plasma membrane | detection of mechanical stimulus involved in sensory perception of pain | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | positive regulation of protein localization to cell surface | osteoclast differentiation | protein localization to membrane | positive regulation of secretion | organic substance transport | cellular response to stress | response to lipid | nervous system process | regulation of epidermis development | myeloid leukocyte differentiation | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of cellular response to oxidative stress | animal organ morphogenesis | endothelial cell apoptotic process | regulation of myelination | positive regulation of heat generation | regulation of nitrogen compound metabolic process | monosaccharide metabolic process | positive regulation of JNK cascade | regulation of cysteine-type endopeptidase activity involved in apoptotic process | small molecule metabolic process | peptide transport | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | response to corticosteroid | regulation of hair follicle development | regulation of branching involved in lung morphogenesis | positive regulation of humoral immune response | regulation of transcription by RNA polymerase II | protein localization to organelle | positive regulation of hydrolase activity | negative regulation of myoblast differentiation | import into nucleus | positive regulation of cell differentiation | second-messenger-mediated signaling | positive regulation of calcium-mediated signaling | negative regulation of viral process | positive regulation of myeloid cell differentiation | positive regulation of leukocyte adhesion to arterial endothelial cell | negative regulation of extrinsic apoptotic signaling pathway | positive regulation of steroid metabolic process | negative regulation of ion transmembrane transport | positive regulation of superoxide dismutase activity | cellular response to cytokine stimulus | cell proliferation | regulation of L-glutamate import across plasma membrane | biosynthetic process | stress-activated MAPK cascade | sensory perception of pain | regulation of hormone metabolic process | regulation of cellular protein metabolic process | positive regulation of immunoglobulin mediated immune response | negative regulation of immune response | phosphorylation | negative regulation of ion transport | positive regulation of endopeptidase activity | carbohydrate metabolic process | positive regulation of neuron death | positive regulation of chemokine production | response to toxic substance | regulation of apoptotic signaling pathway | cellular response to amino acid stimulus | protein phosphorylation | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | phosphate-containing compound metabolic process | protein import | cellular response to drug | negative regulation of protein dephosphorylation | response to bacterium | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of neuron apoptotic process | regulation of lipid catabolic process | regulation of establishment of endothelial barrier | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | humoral immune response | inflammatory response | regulation of cytokine production involved in immune response | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | defense response to bacterium | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of RNA metabolic process | lipopolysaccharide-mediated signaling pathway | positive regulation of transport | regulation of lipid biosynthetic process | regulation of viral process | apoptotic signaling pathway | cellular response to nicotine | regulation of mitotic cell cycle | positive regulation of molecular function | calcium-mediated signaling | regulation of cytokine secretion | positive regulation of translational initiation | activation of MAPK activity | regulation of signaling receptor activity | receptor regulator activity | chronic inflammatory response | regulation of podosome assembly | activation of immune response | negative regulation of bicellular tight junction assembly | negative regulation of epithelial cell proliferation | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | regulation of innate immune response | regulation of hemopoiesis | leukocyte adhesion to vascular endothelial cell | regulation of protein dephosphorylation | epithelial cell proliferation | regulation of kinase activity | response to mechanical stimulus | regulation of animal organ morphogenesis | detection of stimulus involved in sensory perception | positive regulation of steroid biosynthetic process | regulation of response to reactive oxygen species | negative regulation of ossification | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | positive regulation of neuron apoptotic process | establishment of protein localization to organelle | anatomical structure development | positive regulation of calcidiol 1-monooxygenase activity | cell surface receptor signaling pathway | regulation of chronic inflammatory response | leukocyte cell-cell adhesion | negative regulation of lipid metabolic process | metabolic process | lipid localization | negative regulation of growth of symbiont in host | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of protein catabolic process | regulation of adaptive immune response | regulation of RNA biosynthetic process | hexose metabolic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | regulation of myoblast differentiation | regulation of cytokine secretion involved in immune response | negative regulation of mitotic cell cycle | positive regulation of inflammatory response to antigenic stimulus | cellular protein localization | amide transport | regulation of vesicle-mediated transport | negative regulation of endothelial cell proliferation | regulation of secretion | positive regulation of cell death | cell adhesion | receptor ligand activity | positive regulation of interleukin-6 production | immune response | positive regulation of cellular component biogenesis | cytokine activity | organic substance metabolic process | positive regulation of acute inflammatory response | nuclear transport | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of myosin-light-chain-phosphatase activity | regulation of glucose transmembrane transport | animal organ development | regulation of endothelial cell proliferation | negative regulation of cellular protein metabolic process | positive regulation of NF-kappaB transcription factor activity | regulation of protein secretion | positive regulation of programmed cell death | positive regulation of kinase activity | positive regulation of phagocytosis | regulation of calcineurin-NFAT signaling cascade | tumor necrosis factor-mediated signaling pathway | regulation of phosphate metabolic process | cytoskeleton organization | regulation of ion transmembrane transport | detection of mechanical stimulus | establishment of protein localization | cell-cell adhesion | positive regulation of calcineurin-NFAT signaling cascade | positive regulation of cytokine production | regulation of JNK cascade | cell activation | positive regulation of MAPK cascade | positive regulation of protein transport | toll-like receptor 3 signaling pathway | regulation of reactive oxygen species biosynthetic process | regulation of peptidyl-serine phosphorylation | negative regulation of cell cycle | negative regulation of protein metabolic process | sensory perception | positive regulation of chronic inflammatory response | regulation of action potential | regulation of osteoclast differentiation | defense response to Gram-positive bacterium | positive regulation of fever generation | regulation of stress-activated MAPK cascade | regulation of cell communication | sequestering of triglyceride | negative regulation of molecular function | negative regulation of signal transduction | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of immunoglobulin production | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | response to organic cyclic compound | positive regulation of chemokine (C-X-C motif) ligand 2 production | regulation of endocytosis | protein localization | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | negative regulation of phosphoprotein phosphatase activity | regulation of cytokine production | anatomical structure morphogenesis | regulation of endopeptidase activity | cellular macromolecule localization | positive regulation of MAP kinase activity | response to biotic stimulus | nucleocytoplasmic transport | regulation of nervous system development | regulation of developmental process | regulation of ion transport | regulation of phosphoprotein phosphatase activity | epithelial cell proliferation involved in salivary gland morphogenesis | developmental process | organelle organization | positive regulation of cell cycle process | cellular protein modification process | chronic inflammatory response to antigenic stimulus | cortical cytoskeleton organization | negative regulation of cytokine secretion involved in immune response | positive regulation of translational initiation by iron | cellular extravasation | regulation of chemokine production | negative regulation of transcription by RNA polymerase II | regulation of cell junction assembly | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | necrotic cell death | negative regulation of cell proliferation | regulation of cell-cell adhesion | regulation of hair cycle | receptor metabolic process | regulation of endothelial cell differentiation | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | negative regulation of dephosphorylation | positive regulation of transcription by RNA polymerase II | positive regulation of epidermis development | negative regulation of hydrolase activity | regulation of anion transport | positive regulation of nitric oxide biosynthetic process | positive regulation of JUN kinase activity | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of interleukin-8 biosynthetic process | positive regulation of lipid metabolic process | regulation of interferon-gamma production | positive regulation of myeloid leukocyte differentiation | immune system process | cellular metabolic process | regulation of viral genome replication | hematopoietic or lymphoid organ development | response to tumor necrosis factor | cellular response to organic substance | regulation of protein localization | exocrine system development | regulation of cell death | regulation of smooth muscle cell proliferation | salivary gland development | response to steroid hormone | regulation of organelle assembly | regulation of translation | regulation of viral life cycle | negative regulation of cell death | regulation of interleukin-6 production | regulation of inflammatory response | negative regulation of myelination | positive regulation of endocytosis | positive regulation of leukocyte cell-cell adhesion | regulation of I-kappaB kinase/NF-kappaB signaling | negative regulation of cell differentiation | regulation of cellular component organization | response to other organism | positive regulation of signaling | positive regulation of mitotic nuclear division | signal transduction | regulation of signaling | positive regulation of gene expression | response to glucocorticoid | regulation of hormone biosynthetic process | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
secretory granule | integral component of membrane | cytoplasmic vesicle | cell | intrinsic component of membrane | external side of plasma membrane | cytoplasm | intracellular organelle | membrane microdomain | recycling endosome | secretory vesicle | endomembrane system | plasma membrane | membrane raft | vesicle | integral component of plasma membrane | endosome | extracellular region | membrane-bounded organelle | organelle | phagocytic cup | extracellular space | cell periphery | intracellular vesicle | cell surface | intracellular | membrane | intrinsic component of plasma membrane
