QuickView for TOLL;jsessionid=618083722A248723A91A9042D518EE14;jsessionid=01AADE7E7295378F08CAFADA67EEB9C2 (gene)
- Gene Symbol:
- TLR4
Bos taurus - Full name:
- toll-like receptor 4
- Synonyms:
- N/A
- Genomic Location:
- Chr 8: 112426793-112437806
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Canis lupus familiaris , Gallus gallus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
transmembrane signaling receptor activity | signaling receptor activity | signaling pattern recognition receptor activity | lipopolysaccharide receptor activity
GO Biological Process
positive regulation of immune response | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | positive regulation of macrophage cytokine production | positive regulation of macromolecule biosynthetic process | negative regulation of MAPK cascade | detection of stimulus | regulation of cellular response to oxidative stress | positive regulation of cellular component organization | regulation of response to oxidative stress | regulation of B cell activation | immune response-regulating signaling pathway | response to lipopolysaccharide | intracellular signal transduction | regulation of localization | interleukin-1 secretion | negative regulation of interleukin-23 production | defense response to other organism | establishment of localization | regulation of immune system process | regulation of nitric oxide biosynthetic process | astrocyte development | negative regulation of cellular process | regulation of MAP kinase activity | epithelial structure maintenance | positive regulation of lymphocyte activation | regulation of interferon-beta biosynthetic process | cell differentiation | defense response | nervous system development | negative regulation of protein phosphorylation | neurogenesis | positive regulation of phosphate metabolic process | tissue homeostasis | defense response to Gram-negative bacterium | regulation of neuron death | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | cellular process | production of molecular mediator involved in inflammatory response | secretion | toll-like receptor signaling pathway | regulation of cytokine biosynthetic process | localization | protein transport | negative regulation of signaling | positive regulation of immune effector process | positive regulation of blood coagulation | positive regulation of reactive oxygen species metabolic process | I-kappaB phosphorylation | positive regulation of macrophage activation | positive regulation of protein kinase activity | macromolecule localization | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | cellular response to oxidised low-density lipoprotein particle stimulus | anatomical structure homeostasis | regulation of interferon-beta production | regulation of platelet activation | regulation of immune response | regulation of cellular process | leukocyte activation | cellular response to lipid | regulation of metabolic process | gliogenesis | positive regulation of stress-activated MAPK cascade | regulation of protein complex assembly | cellular response to molecule of bacterial origin | positive regulation of NLRP3 inflammasome complex assembly | positive regulation of interferon-gamma production | negative regulation of tumor necrosis factor production | positive regulation of cellular protein metabolic process | positive regulation of tumor necrosis factor production | regulation of peptide secretion | regulation of type I interferon production | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | interleukin-1 beta secretion | positive regulation of innate immune response | positive regulation of nitric oxide metabolic process | positive regulation of immune system process | positive regulation of protein metabolic process | mononuclear cell proliferation | interleukin-1 beta production | response to stress | negative regulation of tumor necrosis factor superfamily cytokine production | leukocyte activation involved in immune response | positive regulation of lymphocyte proliferation | regulation of cell proliferation | multicellular organismal homeostasis | negative regulation of interferon-gamma production | positive regulation of B cell proliferation | positive regulation of cytokine biosynthetic process | positive regulation of cell activation | activation of innate immune response | secretion by cell | response to molecule of bacterial origin | immune response-activating signal transduction | detection of lipopolysaccharide | regulation of protein transport | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | regulation of wound healing | protein modification process | regulation of peptide transport | positive regulation of response to oxidative stress | macromolecule modification | negative regulation of ERK1 and ERK2 cascade | activation of protein kinase activity | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | regulation of neurotransmitter levels | response to nitrogen compound | positive regulation of reactive oxygen species biosynthetic process | regulation of NLRP3 inflammasome complex assembly | positive regulation of mononuclear cell proliferation | response to external biotic stimulus | system development | detection of molecule of bacterial origin | positive regulation of response to wounding | nitrogen compound metabolic process | regulation of signal transduction | detection of chemical stimulus | pattern recognition receptor signaling pathway | negative regulation of phosphate metabolic process | negative regulation of interleukin-6 production | multicellular organism development | regulation of MAPK cascade | phosphorus metabolic process | positive regulation of inflammatory response | maintenance of gastrointestinal epithelium | negative regulation of cold-induced thermogenesis | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of gene expression | organic substance transport | response to lipid | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of cellular response to oxidative stress | digestive system process | regulation of lymphocyte activation | regulation of blood coagulation | regulation of nitrogen compound metabolic process | positive regulation of JNK cascade | positive regulation of interleukin-12 production | peptide transport | positive regulation of intracellular signal transduction | positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway | positive regulation of protein complex assembly | regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway | regulation of transcription by RNA polymerase II | positive regulation of cytokine production involved in inflammatory response | negative regulation of interleukin-17 production | B cell activation | cell proliferation | regulation of cytokine production involved in inflammatory response | leukocyte proliferation | regulation of cellular protein metabolic process | TRIF-dependent toll-like receptor signaling pathway | glial cell differentiation | phosphorylation | positive regulation of neuron death | positive regulation of chemokine production | regulation of interleukin-23 production | protein phosphorylation | regulation of tumor necrosis factor production | phosphate-containing compound metabolic process | B cell proliferation involved in immune response | regulation of macrophage activation | response to bacterium | intestinal epithelial structure maintenance | regulation of interleukin-1 production | peptide secretion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of platelet activation | positive regulation of interleukin-1 production | positive regulation of interferon-beta biosynthetic process | signaling pattern recognition receptor activity | inflammatory response | astrocyte differentiation | cell activation involved in immune response | regulation of cytokine production involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | defense response to bacterium | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | positive regulation of oxidative stress-induced cell death | regulation of RNA metabolic process | lipopolysaccharide-mediated signaling pathway | positive regulation of B cell activation | cellular response to lipoprotein particle stimulus | regulation of nucleotide-binding oligomerization domain containing signaling pathway | lymphocyte activation | positive regulation of interferon-alpha production | positive regulation of molecular function | regulation of cytokine secretion | activation of MAPK activity | cytokine production | positive regulation of myeloid leukocyte cytokine production involved in immune response | activation of immune response | protein metabolic process | regulation of establishment of protein localization | positive regulation of MHC class II biosynthetic process | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | lipopolysaccharide receptor activity | MyD88-independent toll-like receptor signaling pathway | regulation of kinase activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular response to lipoteichoic acid | anatomical structure development | cell surface receptor signaling pathway | metabolic process | cytokine secretion | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | regulation of body fluid levels | positive regulation of coagulation | positive regulation of cytokine production involved in immune response | amide transport | regulation of secretion | positive regulation of cell death | toll-like receptor 4 signaling pathway | positive regulation of interleukin-6 production | macrophage activation | immune response | positive regulation of cellular component biogenesis | organic substance metabolic process | negative regulation of cellular protein metabolic process | regulation of cell activation | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | regulation of phosphate metabolic process | positive regulation of wound healing | regulation of dendritic cell cytokine production | nitric oxide production involved in inflammatory response | establishment of protein localization | positive regulation of cytokine production | regulation of JNK cascade | cell activation | positive regulation of MAPK cascade | regulation of reactive oxygen species biosynthetic process | negative regulation of protein metabolic process | lymphocyte proliferation | regulation of response to wounding | regulation of stress-activated MAPK cascade | regulation of cell communication | positive regulation of interleukin-10 production | negative regulation of signal transduction | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | glial cell development | cell development | I-kappaB kinase/NF-kappaB signaling | protein localization | B cell activation involved in immune response | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | positive regulation of MAP kinase activity | response to biotic stimulus | positive regulation of oxidative stress-induced neuron death | detection of biotic stimulus | developmental process | cellular protein modification process | B cell proliferation | digestion | regulation of chemokine production | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | regulation of B cell proliferation | innate immune response | MyD88-dependent toll-like receptor signaling pathway | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | positive regulation of nitric oxide biosynthetic process | central nervous system development | positive regulation of metabolic process | regulation of interferon-gamma production | immune system process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | protein secretion | positive regulation of type I interferon production | regulation of interleukin-6 production | regulation of inflammatory response | regulation of I-kappaB kinase/NF-kappaB signaling | regulation of cellular component organization | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of nitric-oxide synthase biosynthetic process | positive regulation of gene expression | interferon-gamma production | positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway | cellular response to lipopolysaccharide | macromolecule metabolic process | positive regulation of interferon-beta production | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | receptor complex | protein-containing complex | endomembrane system | vesicle | endosome | membrane-bounded organelle | organelle | early endosome | intracellular vesicle | lipopolysaccharide receptor complex | intracellular | membrane
