QuickView for TOP2A;jsessionid=2E8415F1A4A7C1050B8411064AD58138;jsessionid=F2DD947C14F5B0A326F0A016BA698064 (gene)
- Gene Symbol:
- Top2a
Rattus norvegicus - Full name:
- DNA topoisomerase II alpha
- Synonyms:
- DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme, topoisomerase (DNA) 2 alpha, topoisomerase (DNA) II alpha
- Genomic Location:
- Chr 10: 87771337-87802031
- Description:
-
DNA topoisomerase, a nuclear enzyme that can alter the topologic state of DNA during transcription
- Orthologs:
- Homo sapiens , Mus musculus , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
sequence-specific DNA binding | kinase binding | cation binding | protein kinase binding | magnesium ion binding | isomerase activity | enzyme binding | nucleic acid binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | ATPase activity | pyrophosphatase activity | ubiquitin binding | catalytic activity | chromatin binding | ATP binding | protein kinase C binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | ATPase activity, coupled | DNA binding | purine nucleotide binding | identical protein binding | protein heterodimerization activity | DNA topoisomerase type II (ATP-hydrolyzing) activity | ubiquitin-like protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | DNA binding, bending | DNA topoisomerase II activity | protein binding | protein homodimerization activity | protein dimerization activity | hydrolase activity, acting on acid anhydrides | purine ribonucleotide binding | adenyl ribonucleotide binding | DNA-dependent ATPase activity | drug binding | histone deacetylase binding | metal ion binding | heterocyclic compound binding | DNA topoisomerase activity | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | protein C-terminus binding | small molecule binding
GO Biological Process
brain development | response to radiation | positive regulation of macromolecule biosynthetic process | positive regulation of apoptotic process | regulation of programmed cell death | response to hormone | negative regulation of cellular process | cell differentiation | nervous system development | response to drug | cerebellum morphogenesis | neurogenesis | regulation of organelle organization | generation of neurons | positive regulation of viral life cycle | positive regulation of cellular biosynthetic process | cellular process | mitotic DNA integrity checkpoint | apoptotic nuclear changes | resolution of meiotic recombination intermediates | central nervous system neuron differentiation | immune system development | multicellular organismal reproductive process | cerebellar granule cell differentiation | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | gamete generation | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of viral genome replication | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | head development | response to stimulus | female gamete generation | metencephalon development | chromosome segregation | response to stress | hematopoietic progenitor cell differentiation | execution phase of apoptosis | programmed cell death | reproduction | cell differentiation in hindbrain | cellular component disassembly involved in execution phase of apoptosis | rhythmic process | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | embryo development | DNA recombination | meiotic chromosome segregation | cerebellar Purkinje cell layer formation | meiotic chromosome separation | regulation of nucleic acid-templated transcription | apoptotic process | cerebellar granular layer morphogenesis | system development | nitrogen compound metabolic process | reproductive process | positive regulation of viral process | multicellular organism development | sister chromatid segregation | cellular response to DNA damage stimulus | cerebellum development | apoptotic chromosome condensation | regulation of gene expression | cerebellar granular layer development | cellular response to stress | cell cycle | chromosome condensation | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | cerebellar Purkinje cell differentiation | cell division | positive regulation of single stranded viral RNA replication via double stranded DNA intermediate | hindbrain development | response to parathyroid hormone | nuclear chromosome segregation | DNA topological change | regulation of cellular metabolic process | cerebellar cortex morphogenesis | regulation of RNA metabolic process | regulation of viral process | regulation of mitotic cell cycle | negative regulation of DNA duplex unwinding | neuron differentiation | multicellular organism reproduction | response to organic substance | DNA metabolic process | reciprocal meiotic recombination | anatomical structure development | mitotic cell cycle | nuclear division | metabolic process | regulation of single stranded viral RNA replication via double stranded DNA intermediate | regulation of RNA biosynthetic process | negative regulation of mitotic cell cycle | cerebellar cortex development | hindbrain morphogenesis | positive regulation of cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | cerebellar Purkinje cell layer development | animal organ development | positive regulation of programmed cell death | DNA packaging | regulation of chromosome organization | meiosis I | embryonic cleavage | anatomical structure formation involved in morphogenesis | negative regulation of cell cycle | cerebellar cortex formation | meiotic cell cycle | negative regulation of chromosome organization | regulation of transcription, DNA-templated | DNA ligation | anatomical structure morphogenesis | homologous recombination | regulation of circadian rhythm | developmental process | organelle organization | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | DNA conformation change | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | central nervous system development | positive regulation of metabolic process | chromosome organization | cerebellar Purkinje cell layer morphogenesis | immune system process | mitotic cell cycle checkpoint | cellular metabolic process | regulation of viral genome replication | hematopoietic or lymphoid organ development | regulation of cell death | chromosome separation | cell cycle checkpoint | regulation of viral life cycle | aging | sexual reproduction | regulation of cellular component organization | response to ionizing radiation | female meiotic nuclear division | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
chromosome | centriole | intracellular membrane-bounded organelle | microtubule organizing center | DNA topoisomerase complex (ATP-hydrolyzing) | cell | nuclear lumen | nucleolus | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | nuclear chromosome | ribonucleoprotein complex | microtubule cytoskeleton | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytoskeleton | intracellular | condensed chromosome
