QuickView for TP53;jsessionid=A7FB30FC259DD656C4F43F7145501871;jsessionid=5DD6EE51EE1DB86B6AB1531104D8B687 (gene)
- Gene Symbol:
- TP53
Canis lupus familiaris - Full name:
- tumor protein p53
- Synonyms:
- P53
- Genomic Location:
- Chr 5: 35557006-35560761
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
AACTTT_UNKNOWN , SOX5_01 , NFKAPPAB65_01 , CREL_01 , NFKAPPAB_01 , MZF1_02 , MYCMAX_02 , ACTAYRNNNCCCR_UNKNOWN , HNF4_01 , AHR_01
GO Molecular Function
sequence-specific DNA binding | protein self-association | kinase binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | core promoter binding | protein phosphatase 2A binding | enhancer binding | cation binding | protein kinase binding | proximal promoter sequence-specific DNA binding | receptor tyrosine kinase binding | enzyme binding | nucleic acid binding | ribonucleotide binding | disordered domain specific binding | mRNA binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | chromatin binding | chaperone binding | protein domain specific binding | ATP binding | protein N-terminus binding | ubiquitin-like protein ligase binding | TFIID-class transcription factor binding | anion binding | adenyl nucleotide binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | p53 binding | DNA binding | sequence-specific double-stranded DNA binding | purine nucleotide binding | promoter-specific chromatin binding | identical protein binding | protein heterodimerization activity | ion binding | organic cyclic compound binding | protein tyrosine kinase binding | copper ion binding | transcription regulatory region sequence-specific DNA binding | purine ribonucleoside triphosphate binding | protein binding | histone acetyltransferase binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | protein phosphatase binding | transcription factor binding | ubiquitin protein ligase binding | RNA polymerase II transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | transition metal ion binding | core promoter sequence-specific DNA binding | purine ribonucleotide binding | adenyl ribonucleotide binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding involved in preinitiation complex assembly | drug binding | transcription factor activity, core RNA polymerase binding | protease binding | phosphatase binding | mRNA 3'-UTR binding | histone deacetylase binding | metal ion binding | basal RNA polymerase II transcription machinery binding | heterocyclic compound binding | small molecule binding | RNA binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | response to extracellular stimulus | protein homooligomerization | DNA-templated transcription, initiation | response to radiation | regulation of cell cycle process | cellular response to glucose starvation | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | response to nutrient levels | response to endoplasmic reticulum stress | DNA strand renaturation | positive regulation of cellular component organization | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell cycle G1/S phase transition | regulation of programmed cell death | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | positive regulation of intrinsic apoptotic signaling pathway | intrinsic apoptotic signaling pathway in response to DNA damage | cellular response to extracellular stimulus | response to drug | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | regulation of protein oligomerization | regulation of organelle organization | response to antibiotic | negative regulation of DNA metabolic process | positive regulation of cellular biosynthetic process | regulation of transcription initiation from RNA polymerase II promoter | cellular process | negative regulation of DNA biosynthetic process | localization | chromatin organization | mitotic DNA integrity checkpoint | negative regulation of G1/S transition of mitotic cell cycle | positive regulation of reactive oxygen species metabolic process | negative regulation of nucleic acid-templated transcription | macromolecule localization | negative regulation of apoptotic process | response to hypoxia | positive regulation of release of cytochrome c from mitochondria | cellular response to starvation | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | interspecies interaction between organisms | DNA geometric change | intrinsic apoptotic signaling pathway | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | regulation of protein complex assembly | small GTPase mediated signal transduction | organic cyclic compound metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | signal transduction involved in mitotic DNA damage checkpoint | cellular component organization | response to UV | stress-induced premature senescence | response to stimulus | regulation of mitotic cell cycle phase transition | cellular response to light stimulus | cellular response to hypoxia | response to stress | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | response to peptide | regulation of cell cycle phase transition | circadian rhythm | response to starvation | response to actinomycin D | programmed cell death | protein-DNA complex assembly | rhythmic process | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | mRNA metabolic process | cellular biosynthetic process | positive regulation of mitochondrion organization | DNA repair | regulation of nucleic acid-templated transcription | response to nitrogen compound | apoptotic process | cellular response to actinomycin D | response to light stimulus | cellular response to nutrient levels | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | DNA damage response, signal transduction by p53 class mediator | negative regulation of growth | cellular response to antibiotic | mitotic DNA damage checkpoint | multicellular organism development | negative regulation of catalytic activity | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly | cellular response to DNA damage stimulus | protein complex oligomerization | regulation of catalytic activity | cellular response to oxidative stress | ER-nucleus signaling pathway | regulation of intrinsic apoptotic signaling pathway | DNA damage response, signal transduction resulting in transcription | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of gene expression | oligodendrocyte apoptotic process | rhythmic behavior | cellular response to stress | cellular response to peptide | cell cycle | regulation of cell cycle arrest | positive regulation of cellular metabolic process | regulation of telomerase activity | cellular response to radiation | regulation of pri-miRNA transcription by RNA polymerase II | cellular response to oxygen levels | glial cell apoptotic process | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | regulation of transcription by RNA polymerase II | protein homotetramerization | cellular response to gamma radiation | response to oxidative stress | biosynthetic process | aromatic compound biosynthetic process | oxidative stress-induced premature senescence | positive regulation of pri-miRNA transcription by RNA polymerase II | regulation of RNA polymerase II transcriptional preinitiation complex assembly | cellular protein-containing complex assembly | protein tetramerization | regulation of apoptotic signaling pathway | DNA-templated transcriptional preinitiation complex assembly | signal transduction involved in cell cycle checkpoint | response to gamma radiation | RNA polymerase II transcriptional preinitiation complex assembly | cellular response to UV | autophagy | cellular response to drug | regulation of mitochondrion organization | mitotic G1 DNA damage checkpoint | cell communication | regulation of cellular metabolic process | positive regulation of signal transduction | mRNA transcription | regulation of RNA metabolic process | viral process | negative regulation of cell growth | apoptotic signaling pathway | cell aging | ER overload response | regulation of mitotic cell cycle | positive regulation of cell cycle arrest | positive regulation of execution phase of apoptosis | protein-containing complex assembly | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | regulation of fibroblast proliferation | DNA-binding transcription factor activity | regulation of growth | response to organic substance | G1 DNA damage checkpoint | cell cycle arrest | DNA metabolic process | replicative senescence | regulation of intracellular signal transduction | chromatin assembly or disassembly | anatomical structure development | mitotic cell cycle | entrainment of circadian clock | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | metabolic process | nucleotide-excision repair | positive regulation of DNA-templated transcription, initiation | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | negative regulation of mitotic cell cycle | behavior | positive regulation of cell death | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | positive regulation of cellular component biogenesis | organic substance metabolic process | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | positive regulation of programmed cell death | signal transduction involved in mitotic cell cycle checkpoint | cellular response to ionizing radiation | DNA packaging | intrinsic apoptotic signaling pathway by p53 class mediator | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | chromatin assembly | negative regulation of cell cycle | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | negative regulation of molecular function | cellular senescence | signaling | regulation of transcription, DNA-templated | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | protein localization | negative regulation of fibroblast proliferation | cellular macromolecule biosynthetic process | regulation of DNA-templated transcription, initiation | signal transduction involved in DNA damage checkpoint | response to biotic stimulus | regulation of circadian rhythm | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding involved in preinitiation complex assembly | transcription factor activity, core RNA polymerase binding | developmental process | organelle organization | regulation of DNA biosynthetic process | positive regulation of cell cycle process | regulation of cell growth | mitotic G1/S transition checkpoint | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | positive regulation of protein oligomerization | negative regulation of cell proliferation | Ras protein signal transduction | circadian behavior | positive regulation of nucleic acid-templated transcription | entrainment of circadian clock by photoperiod | DNA conformation change | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | photoperiodism | heterocycle metabolic process | signal transduction involved in mitotic G1 DNA damage checkpoint | positive regulation of metabolic process | chromosome organization | regulation of execution phase of apoptosis | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | cellular response to organic substance | regulation of cell death | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | negative regulation of cell death | aging | negative regulation of telomerase activity | regulation of cellular component organization | response to ionizing radiation | positive regulation of transcription initiation from RNA polymerase II promoter | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
nuclear transcription factor complex | mitochondrial matrix | chromosome | intracellular membrane-bounded organelle | catalytic complex | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | nucleolus | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear body | protein-containing complex | PML body | endomembrane system | nucleoplasm | chromatin | nuclear chromosome | transferase complex | mitochondrion | membrane-bounded organelle | nucleus | organelle | nuclear DNA-directed RNA polymerase complex | transcription factor TFIID complex | RNA polymerase complex | membrane-enclosed lumen | nuclear matrix | nuclear chromatin | cytosol | intracellular | RNA polymerase II, holoenzyme | nuclear periphery
