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QuickView for Vav;jsessionid=ACFA1D12F246175FAFAA73D062C4AE89;jsessionid=C7A47EF0D8A0ED55C66EC826C22ACFF7 (gene)


Gene Symbol:
Vav1 Rattus norvegicus Rattus norvegicus
Full name:
vav guanine nucleotide exchange factor 1
Synonyms:
Vav, proto-oncogene vav, p95, vav 1 guanine nucleotide exchange factor, vav 1 oncogene
Genomic Location:
Chr Un: 64587013-64639934
Description:
guanine nucleotide exchange factor (GEF) from the Rho family of GTP binding proteins; plays a role in T-cell and B-cell development; can activate the c-Jun N-terminal kinase-1 (JNK1) pathway
Orthologs:
Homo sapiens Mus musculus D. melanogaster Macaca mulatta Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):


Transcripts Names
NM_012759
Protein Names
Q5BK91



GO Molecular Function

protein phosphorylated amino acid binding | Rho guanyl-nucleotide exchange factor activity | guanyl-nucleotide exchange factor activity | GTPase binding | Rho GTPase binding | cation binding | enzyme binding | phosphotyrosine residue binding | Ras GTPase binding | molecular function regulator | ion binding | phosphoprotein binding | protein binding | Rac GTPase binding | Ras guanyl-nucleotide exchange factor activity | small GTPase binding | metal ion binding | Rac guanyl-nucleotide exchange factor activity

GO Biological Process

positive regulation of immune response | positive regulation of cell killing | Rho guanyl-nucleotide exchange factor activity | guanyl-nucleotide exchange factor activity | cell motility | immune response-regulating signaling pathway | intracellular signal transduction | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | integrin-mediated signaling pathway | cell differentiation | reactive oxygen species metabolic process | regulation of leukocyte mediated cytotoxicity | positive regulation of cell adhesion | positive regulation of GTPase activity | cellular process | lymphocyte differentiation | localization | positive regulation of immune effector process | immune system development | positive regulation of catalytic activity | granulocyte chemotaxis | regulation of immune response | regulation of cellular process | leukocyte activation | small GTPase mediated signal transduction | cellular component organization | T cell activation | positive regulation of natural killer cell mediated immunity | response to stimulus | positive regulation of innate immune response | neutrophil chemotaxis | positive regulation of immune system process | G-protein coupled receptor signaling pathway | regulation of cellular component size | hemopoiesis | regulation of cell adhesion | cell chemotaxis | molecular function regulator | leukocyte migration | leukocyte differentiation | locomotion | system development | regulation of signal transduction | multicellular organism development | cell migration | regulation of catalytic activity | regulation of small GTPase mediated signal transduction | vesicle-mediated transport | positive regulation of hydrolase activity | regulation of Rho protein signal transduction | regulation of GTPase activity | cell communication | leukocyte chemotaxis | lymphocyte activation | positive regulation of molecular function | T cell differentiation | regulation of innate immune response | import into cell | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | metabolic process | Ras guanyl-nucleotide exchange factor activity | endocytosis | immune response | animal organ development | positive regulation of natural killer cell mediated cytotoxicity | cell activation | regulation of natural killer cell mediated cytotoxicity | regulation of cell communication | signaling | cell development | regulation of cell size | regulation of Ras protein signal transduction | developmental process | positive regulation of leukocyte mediated cytotoxicity | Rac guanyl-nucleotide exchange factor activity | immune system process | regulation of natural killer cell mediated immunity | cellular metabolic process | hematopoietic or lymphoid organ development | neutrophil migration | chemotaxis | phagocytosis | signal transduction | regulation of signaling | multicellular organismal process

GO Cellular Component

cell | cell-cell junction | intracellular | cell junction