QuickView for YDL097C;jsessionid=9517459AD011A7DC7CA8A20CCD617B1A;jsessionid=3A4BFFCA38ADE9B15E4CE64999EB0A51 (gene)

Gene Symbol:

PSMD11 Homo sapiens

Full name:

proteasome 26S subunit, non-ATPase 11

Synonyms:

Rpn6, S9, p44.5, 26S proteasome non-ATPase regulatory subunit 11, 26S proteasome regulatory subunit 9, 26S proteasome regulatory subunit RPN6, 26S proteasome regulatory subunit S9, 26S proteasome regulatory subunit p44.5, proteasome (prosome, macropain) 26S subunit, non-ATPase, 11

Genomic Location:

Chr 17: 27795615-27832155

Description:

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which cont...

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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  TGANNYRGCA_TCF11MAFG_01 ,  CIZ_01 ,  AP1_Q6 ,  CTTTGA_LEF1_Q2 ,  NFE2_01 ,  TTGGAGA_MIR5155P_MIR519E ,  TCCCRNNRTGC_UNKNOWN ,  TITF1_Q3 ,  CATGTAA_MIR496 ,  AP1_01 ,  AP1FJ_Q2 ,  RRAGTTGT_UNKNOWN ,  BACH2_01 ,  ATTCTTT_MIR186 ,  TGCTGAY_UNKNOWN ,  AP1_Q2_01 ,  ACTAYRNNNCCCR_UNKNOWN ,  AP1_Q4 ,  ACTWSNACTNY_UNKNOWN ,  BACH1_01 ,  AP1_Q2 ,  FOXM1_01 ,  AACTTT_UNKNOWN ,  AP1_Q4_01 ,  TCF11MAFG_01 ,  TGASTMAGC_NFE2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

17q11.2

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