QuickView for YDL147W;jsessionid=4B88CBCD4DA41E919C3EBB0D1CC53192;jsessionid=6AA4544621AEFE41E127D2395BD1207A;jsessionid=4D1FCD59BDCDDFA9E6499F874AD14A2C;jsessionid=E42FC905BA7DD1ED7EB788260443F91E (gene)

Gene Symbol:

PSMD12 Homo sapiens

Full name:

proteasome 26S subunit, non-ATPase 12

Synonyms:

Rpn5, STISS, p55, 26S proteasome non-ATPase regulatory subunit 12, 26S proteasome regulatory subunit RPN5, 26S proteasome regulatory subunit p55, proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

Genomic Location:

Chr 17: 62767081-62793183

Description:

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which cont...

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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  ATF4_Q2 ,  AP1_Q6 ,  NFE2_01 ,  AP1_Q6_01 ,  AP1_01 ,  E4F1_Q6 ,  GCM_Q2 ,  GACTGTT_MIR212_MIR132 ,  NRF2_Q4 ,  BACH1_01 ,  CETS1P54_01 ,  SCGGAAGY_ELK1_02 ,  NRF2_01 ,  ELK1_02 ,  TGASTMAGC_NFE2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-132

Cytogenetic Map:

17q24.2

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