QuickView for apoB;jsessionid=A154A5B4ADC4FCCA42DF09A269180640;jsessionid=224D4189CBA0DADD52A6B4DF39303BA8 (gene)

Gene Symbol:

Apob Mus musculus

Full name:

apolipoprotein B

Synonyms:

AI315052, Apo B-100, apob-100, apob-48, apolipoprotein B-100

Genomic Location:

Chr 12: 8017208-8023641

Description:

This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100. Unlike the apoB-48 and apoB-100 structural equivalents in human, which are synthesized exclusively in the gut and liver, respectively, the mouse apoB-48 isoform is also found in mouse liver. The ...

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This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100. Unlike the apoB-48 and apoB-100 structural equivalents in human, which are synthesized exclusively in the gut and liver, respectively, the mouse apoB-48 isoform is also found in mouse liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2179 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GAGCCAG_MIR149 ,  RTAAACA_FREAC2_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-149

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