QuickView for apoB;jsessionid=A154A5B4ADC4FCCA42DF09A269180640;jsessionid=C8638D4EDFF8C46066925E18C3040B83 (gene)

Gene Symbol:

Apob Rattus norvegicus

Full name:

apolipoprotein B

Synonyms:

Aa1064, Ac1-060, Apo B-100, ApoB-100, ApoB-48, apolipoprotein B-100, apolipoprotein B (including Ag(x) antigen), apolipoprotein B PI, apolipoprotein B-48

Genomic Location:

Chr 6: 31508012-31556597

Description:

This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-L and apoB-H. Unlike the apoB-48 and apoB-100 structural equivalents in human, which are synthesized exclusively in the gut and liver, respectively, the rat apoBL isoform is also found in rat liver. The intestina...

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This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-L and apoB-H. Unlike the apoB-48 and apoB-100 structural equivalents in human, which are synthesized exclusively in the gut and liver, respectively, the rat apoBL isoform is also found in rat liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-L protein is produced after RNA editing of the apoB-H transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination.

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Orthologs:

Homo sapiens ,  Mus musculus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GAGCCAG_MIR149 ,  RTAAACA_FREAC2_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-149

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