QuickView for c-Fos;jsessionid=A2947A414EC0D50DF49BA24F7C7CC8C6;jsessionid=9216A5C390E6CE629E50239D915743DD (gene)

Gene Symbol:

FOS Homo sapiens

Full name:

Fos proto-oncogene, AP-1 transcription factor subunit

Synonyms:

AP-1, C-FOS, p55, proto-oncogene c-Fos, FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS), FBJ murine osteosarcoma viral oncogene homolog, Fos proto-oncogene, AP-1 trancription factor subunit, G0/G1 switch regulatory protein 7, activator protein 1, cellular oncogene c-fos

Genomic Location:

Chr 14: 74815284-74818666

Description:

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In so...

View Full Description

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  RTAAACA_FREAC2_01 ,  ACTGTAG_MIR139 ,  OCT1_05 ,  SRF_01 ,  AREB6_02 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  VDR_Q3 ,  YTATTTTNR_MEF2_02 ,  SRF_Q6 ,  CTACTGT_MIR199A ,  GCANCTGNY_MYOD_Q6 ,  ATF4_Q2 ,  WGTTNNNNNAAA_UNKNOWN ,  GTACTGT_MIR101 ,  ACTTTAT_MIR1425P ,  CREB_Q4 ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  ATF_B ,  CREBP1_Q2 ,  TATAAA_TATA_01 ,  CEBPDELTA_Q6 ,  MEF2_01 ,  ATF_01 ,  STAT5B_01 ,  CAGGTG_E12_Q6 ,  HSF1_01 ,  YY1_01 ,  AP1FJ_Q2 ,  GAGCTGG_MIR337 ,  AREB6_01 ,  TGCTGAY_UNKNOWN ,  SRF_Q4 ,  SPZ1_01 ,  MEIS1_01 ,  HSF2_01 ,  HMEF2_Q6 ,  ELK1_01 ,  ATF1_Q6 ,  MEF2_03 ,  IRF7_01 ,  CREB_Q2 ,  IK3_01 ,  CTGCAGY_UNKNOWN ,  SRF_Q5_01 ,  AP1_Q2 ,  CTTTGT_LEF1_Q2 ,  STAT5A_01 ,  TBP_01 ,  RCGCANGCGY_NRF1_Q6 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  BRN2_01 ,  AACTTT_UNKNOWN ,  TGACATY_UNKNOWN ,  TCF1P_Q6 ,  PAX2_02 ,  NFKB_C ,  SRF_C ,  TAXCREB_01 ,  ATGTAGC_MIR221_MIR222 ,  STAT5A_02

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-383 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-543

Cytogenetic Map:

14q24.3

search → result