QuickView for c-MYC;jsessionid=5D314ADDB3AC28D40A92492569460247;jsessionid=CDF89105C600736584F6D15FC6D428EC (gene)

Gene Symbol:

Myc Mus musculus

Full name:

myelocytomatosis oncogene

Synonyms:

AU016757, Myc2, Niard, Nird, bHLHe39, myc proto-oncogene protein, c-myc proto-oncogene, transcription factor p64

Genomic Location:

Chr 15: 61816896-61821916

Description:

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated w...

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The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AACTTT_UNKNOWN ,  E2F_01 ,  E2F_02 ,  HEN1_02 ,  E47_02 ,  E2F1_Q4 ,  E2F1_Q6 ,  E2F_03 ,  AFP1_Q6 ,  E2F1DP1_01 ,  E2F1DP2_01 ,  E2F4DP1_01 ,  E2F4DP2_01 ,  TTF1_Q6 ,  E2F_Q3_01 ,  E2F_Q4_01 ,  E2F_Q6_01 ,  AP4_Q6_01 ,  E2F1_Q3_01 ,  E2F1_Q4_01 ,  E2F1_Q6_01 ,  KTGGYRSGAA_UNKNOWN ,  ACAACCT_MIR453 ,  ACTGCCT_MIR34B ,  RRCCGTTA_UNKNOWN ,  CAGCTG_AP4_Q5 ,  CAGGTG_E12_Q6 ,  SGCGSSAAA_E2F1DP2_01 ,  RTAAACA_FREAC2_01 ,  GGGAGGRR_MAZ_Q6 ,  TGACAGNY_MEIS1_01 ,  GCANCTGNY_MYOD_Q6 ,  GGGCGGR_SP1_Q6 ,  TATAAA_TATA_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-496

miRNA binding sites
(Source: miRecords):

mmu-let-7c Targeted Genes

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