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QuickView for caspase-3;jsessionid=668A472189A2ACE74BB528DE7DF9A76D;jsessionid=273238E1D37E49CE08FC89370B412BFB (gene)


Gene Symbol:
Casp3 Rattus norvegicus Rattus norvegicus
Full name:
caspase 3
Synonyms:
CPP32-beta, Lice, Yama, caspase-3, CASP-3, CPP-32, CPP32beta, Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease), IRP, SCA-1, SREBP cleavage activity 1, apopain, cysteine protease CPP32, cysteine protease p32-beta, protein Yama, yama protein
Genomic Location:
Chr 16: 48944226-48962420
Description:
apoptotic cysteine-aspartic acid protease that may play a role in neuronal cell death regulation and other apoptotic processes
Orthologs:
Homo sapiens Mus musculus D. melanogaster Macaca mulatta Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes Danio rerio
External Links:
Entrez Gene
miRNA binding sites
(Source: TargetScan):


Transcripts Names
NM_012922
XM_006253130
Protein Names
P55213
P97699
P70543
Q62993



GO Molecular Function

enzyme activator activity | protein kinase regulator activity | protein serine/threonine kinase inhibitor activity | cysteine-type endopeptidase activity involved in apoptotic signaling pathway | lipase activator activity | kinase regulator activity | protein kinase inhibitor activity | cysteine-type endopeptidase activity involved in apoptotic process | enzyme binding | protein-containing complex binding | aspartic-type peptidase activity | enzyme inhibitor activity | signaling receptor binding | hydrolase activity | cytokine receptor binding | cysteine-type peptidase activity | molecular function regulator | catalytic activity | cysteine-type endopeptidase activity involved in execution phase of apoptosis | death receptor binding | phospholipase A2 activator activity | cysteine-type endopeptidase activity | protein binding | aspartic-type endopeptidase activity | kinase inhibitor activity | phospholipase activator activity | endopeptidase activity | enzyme regulator activity | cyclin-dependent protein serine/threonine kinase inhibitor activity | protease binding | tumor necrosis factor receptor superfamily binding | peptidase activity | cyclin-dependent protein serine/threonine kinase regulator activity

GO Biological Process

leukocyte homeostasis | negative regulation of leukocyte activation | negative regulation of phosphorylation | brain development | response to radiation | negative regulation of immune system process | regulation of B cell activation | negative regulation of activated T cell proliferation | response to lipopolysaccharide | intracellular signal transduction | enzyme activator activity | positive regulation of apoptotic process | proteolysis | protein kinase regulator activity | regulation of programmed cell death | erythrocyte homeostasis | response to X-ray | hippocampus development | regulation of immune system process | response to hormone | myeloid cell differentiation | neuron death | negative regulation of cellular process | negative regulation of kinase activity | negative regulation of leukocyte cell-cell adhesion | protein processing | response to metal ion | cell differentiation | protein serine/threonine kinase inhibitor activity | cysteine-type endopeptidase activity involved in apoptotic signaling pathway | nervous system development | negative regulation of B cell proliferation | response to drug | negative regulation of protein phosphorylation | neurogenesis | lipase activator activity | generation of neurons | response to antibiotic | sensory perception of mechanical stimulus | regulation of neuron death | cellular process | kinase regulator activity | response to estradiol | protein kinase inhibitor activity | cysteine-type endopeptidase activity involved in apoptotic process | immune system development | negative regulation of apoptotic process | response to hypoxia | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | negative regulation of T cell proliferation | response to inorganic substance | negative regulation of cellular metabolic process | tissue development | intrinsic apoptotic signaling pathway | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | negative regulation of mononuclear cell proliferation | aspartic-type peptidase activity | epithelium development | cellular response to organonitrogen compound | response to UV | head development | response to stimulus | enzyme inhibitor activity | negative regulation of cell adhesion | response to stress | negative regulation of lymphocyte activation | negative regulation of protein kinase activity | regulation of cell proliferation | response to glucose | execution phase of apoptosis | programmed cell death | response to molecule of bacterial origin | cellular response to organic cyclic compound | negative regulation of metabolic process | hemopoiesis | cellular response to staurosporine | regulation of cell adhesion | cysteine-type peptidase activity | molecular function regulator | myeloid cell homeostasis | response to nitrogen compound | apoptotic process | response to light stimulus | response to nicotine | response to external biotic stimulus | system development | regulation of cyclin-dependent protein serine/threonine kinase activity | response to oxygen levels | nitrogen compound metabolic process | cysteine-type endopeptidase activity involved in execution phase of apoptosis | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | response to amino acid | learning or memory | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | wound healing | cellular response to ammonium ion | regulation of T cell activation | telencephalon development | regulation of activated T cell proliferation | cellular response to stress | response to lipid | nervous system process | negative regulation of cyclin-dependent protein serine/threonine kinase activity | regulation of lymphocyte activation | response to ammonium ion | glial cell apoptotic process | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | enzyme linked receptor protein signaling pathway | neuron apoptotic process | negative regulation of protein serine/threonine kinase activity | response to corticosteroid | cellular response to alkaloid | response to oxidative stress | B cell homeostasis | cognition | epidermal cell differentiation | homeostasis of number of cells | phospholipase A2 activator activity | response to osmotic stress | regulation of cellular protein metabolic process | neurotrophin signaling pathway | positive regulation of neuron death | protein maturation | epidermis development | response to toxic substance | skin development | keratinocyte differentiation | response to bacterium | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of neuron apoptotic process | lymphocyte homeostasis | negative regulation of cell activation | sensory perception of sound | regulation of protein metabolic process | heart development | homeostatic process | limbic system development | response to monosaccharide | regulation of protein phosphorylation | cysteine-type endopeptidase activity | apoptotic signaling pathway | negative regulation of B cell activation | positive regulation of molecular function | neuron differentiation | negative regulation of cyclin-dependent protein kinase activity | protein metabolic process | response to organic substance | neurotrophin TRK receptor signaling pathway | aspartic-type endopeptidase activity | kinase inhibitor activity | regulation of kinase activity | response to wounding | response to mechanical stimulus | cellular response to osmotic stress | positive regulation of neuron apoptotic process | anatomical structure development | cell surface receptor signaling pathway | metabolic process | cell fate commitment | negative regulation of leukocyte proliferation | negative regulation of programmed cell death | behavior | positive regulation of cell death | organic substance metabolic process | cell death | animal organ development | response to reactive oxygen species | forebrain development | pallium development | negative regulation of cellular protein metabolic process | gene expression | regulation of cell activation | positive regulation of programmed cell death | regulation of phosphate metabolic process | response to alkaloid | intrinsic apoptotic signaling pathway in response to osmotic stress | T cell homeostasis | phospholipase activator activity | negative regulation of cell cycle | negative regulation of protein metabolic process | sensory perception | negative regulation of molecular function | signaling | response to organic cyclic compound | endopeptidase activity | regulation of T cell proliferation | enzyme regulator activity | response to biotic stimulus | developmental process | cyclin-dependent protein serine/threonine kinase inhibitor activity | erythrocyte differentiation | regulation of B cell proliferation | negative regulation of cell proliferation | regulation of cell-cell adhesion | response to organonitrogen compound | epithelial cell differentiation | response to cobalt ion | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | negative regulation of lymphocyte proliferation | immune system process | hematopoietic or lymphoid organ development | peptidase activity | cellular response to organic substance | regulation of cell death | response to carbohydrate | response to steroid hormone | negative regulation of cell death | circulatory system development | response to ionizing radiation | response to other organism | signal transduction | response to glucocorticoid | response to auditory stimulus | cellular response to growth factor stimulus | cyclin-dependent protein serine/threonine kinase regulator activity | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | plasma membrane protein complex | cytoplasm | death-inducing signaling complex | intracellular organelle | membrane microdomain | protein-containing complex | plasma membrane | membrane raft | membrane-bounded organelle | nucleus | organelle | cell periphery | cytosol | intracellular | membrane