QuickView for cis-2;jsessionid=973A456CF23295F480B1D1DCF91F52FE;jsessionid=8188C8C327085EA5FF9D9F27766713EB;jsessionid=596F72A6FA69D4581F29B2CBD2EBB98B;jsessionid=05D5E1057D2AC078294BB4D335C713F8 (gene)

Gene Symbol:

SOCS2 Homo sapiens

Full name:

suppressor of cytokine signaling 2

Synonyms:

CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2, suppressor of cytokine signaling 2, CIS-2, STAT-induced STAT inhibitor 2, cytokine-inducible SH2 protein 2

Genomic Location:

Chr 12: 92487729-92494109

Description:

This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complex...

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This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  ACTGTAG_MIR139 ,  USF_Q6 ,  TCANNTGAY_SREBP1_01 ,  CACGTG_MYC_Q2 ,  WGTTNNNNNAAA_UNKNOWN ,  GTACTGT_MIR101 ,  ARNT_02 ,  CTTTGA_LEF1_Q2 ,  TGACCTY_ERR1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  RGAANNTTC_HSF1_01 ,  SREBP1_01 ,  CAGGTA_AREB6_01 ,  GGATTA_PITX2_Q2 ,  STAT5B_01 ,  HSF1_01 ,  PXR_Q2 ,  WYAAANNRNNNGCG_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  CEBPB_02 ,  GCGNNANTTCC_UNKNOWN ,  CTTTAAR_UNKNOWN ,  AGGTGCA_MIR500 ,  AAAGACA_MIR511 ,  TCCAGAT_MIR5165P ,  GCCNNNWTAAR_UNKNOWN ,  RORA1_01 ,  STAT_01 ,  MYB_Q6 ,  IK1_01 ,  PAX_Q6 ,  TTCYNRGAA_STAT5B_01 ,  RORA2_01 ,  STAT5A_01 ,  NFKB_Q6_01 ,  CTGTTAC_MIR194 ,  AACTTT_UNKNOWN ,  ER_Q6 ,  GGCKCATGS_UNKNOWN ,  GGARNTKYCCA_UNKNOWN ,  NFKB_C ,  STAT5A_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-380-5p ,  Predicted Gene Targets for miR-500

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Cytogenetic Map:

12q22

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