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QuickView for dsirt2;jsessionid=F67158940E90BADC7CE22F60D85A06EB;jsessionid=A136FA6F0DEEBAF99C62E3539C4E0B90 (gene)


Gene Symbol:
SIRT2 Canis lupus familiaris Canis lupus familiaris
Full name:
sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
Synonyms:
N/A
Genomic Location:
Chr 1: 117125313-117142818
Orthologs:
Homo sapiens Mus musculus Rattus norvegicus D. melanogaster Saccharomyces cerevisiae Schizosaccharomyces pombe Danio rerio Pan troglodytes Bos taurus Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:


Transcripts Names
XM_850289
Protein Names
No proteins found.



GO Molecular Function

cofactor binding | tubulin deacetylase activity | histone deacetylase activity (H4-K16 specific) | cation binding | enzyme binding | nucleotide binding | coenzyme binding | hydrolase activity | ubiquitin binding | protein deacetylase activity | NAD+ binding | catalytic activity | chromatin binding | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | NAD-dependent protein deacetylase activity | anion binding | histone deacetylase activity | ubiquitin-like protein binding | ion binding | organic cyclic compound binding | NAD-dependent histone deacetylase activity | protein binding | histone acetyltransferase binding | zinc ion binding | transcription factor binding | NAD-dependent histone deacetylase activity (H4-K16 specific) | NAD binding | transition metal ion binding | deacetylase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | histone deacetylase binding | metal ion binding | heterocyclic compound binding | small molecule binding

GO Biological Process

response to extracellular stimulus | negative regulation of phosphorylation | regulation of cell cycle process | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | response to nutrient levels | positive regulation of cellular component organization | intracellular signal transduction | positive regulation of apoptotic process | proteolysis | regulation of cell development | regulation of programmed cell death | regulation of oogenesis | peptidyl-amino acid modification | Schwann cell differentiation | regulation of meiotic cell cycle | regulation of autophagy | negative regulation of cellular process | positive regulation of developmental process | negative regulation of RNA biosynthetic process | histone modification | cell differentiation | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | tubulin deacetylase activity | positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia | negative regulation of fat cell differentiation | nervous system development | positive regulation of protein catabolic process | negative regulation of protein phosphorylation | histone deacetylation | neurogenesis | regulation of organelle organization | cellular response to epinephrine stimulus | histone deacetylase activity (H4-K16 specific) | regulation of oocyte development | regulation of attachment of spindle microtubules to kinetochore | regulation of chromosome segregation | positive regulation of cellular biosynthetic process | cellular process | tubulin deacetylation | negative regulation of muscle organ development | peripheral nervous system development | organic substance catabolic process | axon ensheathment | proteolysis involved in cellular protein catabolic process | chromatin organization | cellular response to hepatocyte growth factor stimulus | negative regulation of nucleic acid-templated transcription | regulation of striated muscle tissue development | response to hypoxia | regulation of proteolysis | regulation of cell cycle | response to growth factor | positive regulation of nitrogen compound metabolic process | positive regulation of cell division | negative regulation of cellular metabolic process | regulation of binding | regulation of fat cell differentiation | regulation of cell differentiation | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | gliogenesis | catabolic process | regulation of protein complex assembly | cellular response to molecule of bacterial origin | regulation of cell maturation | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | cellular component organization | positive regulation of oogenesis | cellular lipid metabolic process | regulation of cell division | positive regulation of cellular protein catabolic process | response to stimulus | negative regulation of peptidyl-threonine phosphorylation | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | cellular response to hypoxia | response to stress | regulation of cell proliferation | ensheathment of neurons | phosphatidylinositol-mediated signaling | positive regulation of proteolysis involved in cellular protein catabolic process | cellular protein catabolic process | positive regulation of proteolysis | response to molecule of bacterial origin | proteasomal protein catabolic process | regulation of DNA binding | cellular response to organic cyclic compound | negative regulation of muscle tissue development | positive regulation of meiotic cell cycle | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | protein deacetylase activity | macromolecule modification | histone H3 deacetylation | regulation of nucleic acid-templated transcription | response to nitrogen compound | protein kinase B signaling | regulation of NLRP3 inflammasome complex assembly | response to external biotic stimulus | system development | response to oxygen levels | nitrogen compound metabolic process | positive regulation of organelle organization | negative regulation of phosphate metabolic process | myelination | multicellular organism development | NAD-dependent protein deacetylase activity | lipid metabolic process | cellular response to oxidative stress | regulation of phosphorylation | positive regulation of cell cycle | regulation of gene expression | histone deacetylase activity | hepatocyte growth factor receptor signaling pathway | cellular response to stress | protein catabolic process | response to epinephrine | positive regulation of cellular metabolic process | cellular response to oxygen levels | regulation of myelination | regulation of defense response to bacterium | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | positive regulation of attachment of spindle microtubules to kinetochore | regulation of transcription by RNA polymerase II | response to oxidative stress | positive regulation of cell differentiation | protein deacetylation | regulation of cellular protein metabolic process | positive regulation of proteasomal protein catabolic process | positive regulation of cell maturation | glial cell differentiation | inositol lipid-mediated signaling | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia | response to caloric restriction | negative regulation of autophagy | NAD-dependent histone deacetylase activity | response to hepatocyte growth factor | response to bacterium | cell communication | regulation of cellular metabolic process | cellular lipid catabolic process | response to catecholamine | regulation of protein metabolic process | negative regulation of striated muscle tissue development | regulation of protein phosphorylation | histone H4 deacetylation | regulation of RNA metabolic process | positive regulation of meiotic nuclear division | proteasome-mediated ubiquitin-dependent protein catabolic process | positive regulation of molecular function | regulation of proteasomal ubiquitin-dependent protein catabolic process | positive regulation of execution phase of apoptosis | response to monoamine | protein metabolic process | response to organic substance | regulation of meiotic nuclear division | NAD-dependent histone deacetylase activity (H4-K16 specific) | cellular macromolecule catabolic process | phosphatidylinositol 3-kinase signaling | anatomical structure development | Schwann cell development | cell surface receptor signaling pathway | positive regulation of oocyte maturation | metabolic process | positive regulation of cell development | regulation of DNA-templated transcription in response to stress | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | cellular response to caloric restriction | negative regulation of transcription, DNA-templated | regulation of proteasomal protein catabolic process | peptidyl-lysine modification | regulation of oocyte maturation | positive regulation of cell death | lipid catabolic process | negative regulation of protein complex assembly | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of cellular protein metabolic process | positive regulation of chromosome segregation | positive regulation of programmed cell death | negative regulation of transcription from RNA polymerase II promoter in response to stress | regulation of phosphate metabolic process | positive regulation of binding | ubiquitin-dependent protein catabolic process | negative regulation of protein catabolic process | negative regulation of protein metabolic process | organonitrogen compound catabolic process | signaling | covalent chromatin modification | regulation of transcription, DNA-templated | glial cell development | response to organic cyclic compound | cell development | positive regulation of DNA binding | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | response to biotic stimulus | regulation of nervous system development | regulation of developmental process | regulation of transcription from RNA polymerase II promoter in response to hypoxia | developmental process | organelle organization | positive regulation of cell cycle process | peptidyl-lysine deacetylation | cellular protein modification process | negative regulation of defense response to bacterium | negative regulation of NLRP3 inflammasome complex assembly | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | chromosome organization | regulation of execution phase of apoptosis | cellular metabolic process | cellular response to organic substance | positive regulation of oocyte development | regulation of cell death | modification-dependent protein catabolic process | regulation of ubiquitin-dependent protein catabolic process | negative regulation of cell differentiation | regulation of cellular component organization | myelination in peripheral nervous system | response to other organism | negative regulation of reactive oxygen species metabolic process | cellular response to catecholamine stimulus | signal transduction | positive regulation of gene expression | cellular response to growth factor stimulus | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

supramolecular fiber | chromosome | centriole | intracellular membrane-bounded organelle | somatodendritic compartment | microtubule organizing center | cell body | cell | nuclear lumen | neuronal cell body | nucleolus | compact myelin | microtubule | cytoplasm | spindle | intracellular organelle | meiotic spindle | centrosome | cell-cell junction | plasma membrane | perikaryon | midbody | perinuclear region of cytoplasm | microtubule cytoskeleton | mitochondrion | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | paranodal junction | Schmidt-Lanterman incisure | cytosol | cytoskeleton | intracellular | cell junction | myelin sheath | mitotic spindle | membrane | supramolecular complex