QuickView for osteopontin;jsessionid=C8AF4EBDD3EE6B92E5B13B839BDF4167;jsessionid=B58AA8FB0ED08CD005E25D2337B6D138 (gene)

Gene Symbol:

SPP1 Homo sapiens

Full name:

secreted phosphoprotein 1

Synonyms:

BNSP, BSPI, ETA-1, OPN, osteopontin, SPP1/CALPHA1 fusion, early T-lymphocyte activation 1, nephropontin, osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), secreted phosphoprotein 1 variant 6, urinary stone protein, uropontin

Genomic Location:

Chr 4: 89115826-89123587

Description:

The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregula...

View Full Description

The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  AACTTT_UNKNOWN

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-377

Cytogenetic Map:

4q22.1

search → result