QuickView for paralyzed;jsessionid=D921D3EE17914A42C45A0415C3311C42;jsessionid=8DC570F2265188442B7E8B807FB95F49 (gene)

Gene Symbol:

SCN3A Homo sapiens

Full name:

sodium voltage-gated channel alpha subunit 3

Synonyms:

NAC3, Nav1.3, sodium channel protein type 3 subunit alpha, brain III voltage-gated sodium channel, sodium channel protein brain III subunit alpha, sodium channel protein type III subunit alpha, sodium channel, voltage gated, type III alpha subunit, sodium channel, voltage-gated, type III, alpha polypeptide, voltage-gated sodium channel subtype III, voltage-gated sodium channel subunit alpha Nav1.3

Genomic Location:

Chr 2: 165652276-165768823

Description:

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene fam...

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Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  ETS_Q4 ,  RYTTCCTG_ETS2_B ,  ATGTCAC_MIR489 ,  AACTGAC_MIR223 ,  TTTGTAG_MIR520D ,  AACTGGA_MIR145 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  CTTTGA_LEF1_Q2 ,  GTGCAAA_MIR507 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  STAT_Q6 ,  OCT1_Q6 ,  GGATTA_PITX2_Q2 ,  YYCATTCAWW_UNKNOWN ,  TTCYRGAA_UNKNOWN ,  YY1_01 ,  S8_01 ,  RAAGNYNNCTTY_UNKNOWN ,  GACTGTT_MIR212_MIR132 ,  OCT1_06 ,  TTGTTT_FOXO4_01 ,  PIT1_Q6 ,  GATA4_Q3 ,  GTGTCAA_MIR514 ,  CCANNAGRKGGC_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  AAAGGAT_MIR501 ,  FOXO4_02 ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-379 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-363 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-496

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Cytogenetic Map:

2q24.3

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