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Gene Symbol:
DHX8 Homo sapiens Homo sapiens
Full name:
DEAH-box helicase 8
Synonyms:
DDX8, Dhr2, HRH1, PRP22, PRPF22, ATP-dependent RNA helicase DHX8, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase), DEAH (Asp-Glu-Ala-His) box polypeptide 8, DEAH box protein 8, RNA helicase HRH1
Genomic Location:
Chr 17: 38916860-38957206
Description:
This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may b...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Canis lupus familiaris Bos taurus Danio rerio Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 17
17q21.31





GO Molecular Function

ATP-dependent RNA helicase activity | 3'-5' RNA helicase activity | RNA-dependent ATPase activity | nucleic acid binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | ATPase activity | pyrophosphatase activity | catalytic activity | ATP-dependent 3'-5' RNA helicase activity | ATP binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | ATPase activity, coupled | purine nucleotide binding | identical protein binding | ATP-dependent helicase activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | RNA helicase activity | hydrolase activity, acting on acid anhydrides | purine ribonucleotide binding | adenyl ribonucleotide binding | helicase activity | drug binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding | RNA binding

GO Biological Process

RNA metabolic process | RNA processing | cellular process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | RNA splicing | RNA splicing, via transesterification reactions | cellular nitrogen compound metabolic process | mRNA metabolic process | nitrogen compound metabolic process | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | protein-containing complex disassembly | heterocycle metabolic process | spliceosomal complex disassembly | cellular metabolic process | mRNA processing | mRNA splicing, via spliceosome | macromolecule metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | catalytic complex | catalytic step 2 spliceosome | cell | nuclear lumen | intracellular organelle | nuclear body | protein-containing complex | nucleoplasm | U2-type spliceosomal complex | ribonucleoprotein complex | spliceosomal complex | membrane-bounded organelle | nucleus | organelle | U2-type catalytic step 2 spliceosome | membrane-enclosed lumen | intracellular