QuickView for tgfb1;jsessionid=0BB13860637A31AF00E9217BABBBA742;jsessionid=B1E5B06B969330779A39FCA53374C57C (gene)
- Gene Symbol:
- TGFB1
Bos taurus - Full name:
- transforming growth factor, beta 1
- Synonyms:
- N/A
- Genomic Location:
- Chr 18: 50175911-50190726
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , Canis lupus familiaris , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
protein kinase activator activity | protein serine/threonine kinase activator activity | enzyme activator activity | protein kinase regulator activity | kinase regulator activity | enzyme binding | transforming growth factor beta receptor binding | signaling receptor binding | cytokine receptor binding | molecular function regulator | identical protein binding | antigen binding | type I transforming growth factor beta receptor binding | protein binding | receptor regulator activity | kinase activator activity | growth factor activity | receptor ligand activity | type III transforming growth factor beta receptor binding | type II transforming growth factor beta receptor binding | enzyme regulator activity
GO Biological Process
positive regulation of immune response | leukocyte homeostasis | negative regulation of leukocyte activation | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | membrane protein proteolysis | positive regulation of striated muscle cell differentiation | Notch signaling pathway | purine ribonucleotide metabolic process | adaptive immune response | ventricular cardiac muscle tissue morphogenesis | regulation of cell cycle process | purine ribonucleoside monophosphate biosynthetic process | protein kinase activator activity | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of dephosphorylation | regulation of intracellular protein transport | protein serine/threonine kinase activator activity | negative regulation of immune system process | negative regulation of macrophage cytokine production | extracellular structure organization | positive regulation of cellular component organization | regulation of B cell activation | cell motility | response to lipopolysaccharide | developmental process involved in reproduction | regulation of cellular localization | muscle tissue development | intracellular signal transduction | enzyme activator activity | nuclear export | proteolysis | regulation of localization | positive regulation of collagen metabolic process | mammary gland duct morphogenesis | protein kinase regulator activity | morphogenesis of an epithelium | positive regulation of striated muscle tissue development | regulation of carbohydrate metabolic process | regulation of sodium ion transport | regulation of cardiac muscle cell differentiation | positive regulation of peptidyl-tyrosine phosphorylation | positive regulation of peptidyl-threonine phosphorylation | eye development | establishment of localization | regulation of immune system process | response to hormone | myeloid cell differentiation | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | positive regulation of developmental process | regulation of MAP kinase activity | negative regulation of RNA biosynthetic process | positive regulation of lymphocyte activation | regulation of protein localization to membrane | regulation of protein import | cell differentiation | positive regulation of epithelial cell proliferation | regulation of T cell differentiation | positive regulation of fibroblast proliferation | defense response | negative regulation of fat cell differentiation | nervous system development | epithelial to mesenchymal transition | response to drug | negative regulation of protein phosphorylation | cellular chemical homeostasis | positive regulation of biomineral tissue development | positive regulation of DNA recombination | neurogenesis | negative regulation of gene silencing by RNA | bone remodeling | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of organelle organization | ossification involved in bone remodeling | positive regulation of cellular component movement | regulation of fibroblast migration | positive regulation of protein secretion | mesenchyme development | salivary gland morphogenesis | intracellular transport | blood vessel morphogenesis | positive regulation of T cell differentiation | positive regulation of dephosphorylation | positive regulation of phosphatidylinositol 3-kinase activity | positive regulation of cellular biosynthetic process | cellular process | negative regulation of muscle organ development | regulation of production of miRNAs involved in gene silencing by miRNA | evasion or tolerance of host defenses by virus | organic substance catabolic process | lymphocyte differentiation | transforming growth factor beta receptor signaling pathway involved in heart development | regulation of cell motility | localization | cellular homeostasis | epithelial tube morphogenesis | extrinsic apoptotic signaling pathway | protein transport | tissue remodeling | heart morphogenesis | nucleotide metabolic process | developmental growth | positive regulation of immune effector process | positive regulation of peptidyl-serine phosphorylation | negative regulation of protein localization to plasma membrane | kinase regulator activity | positive regulation of reactive oxygen species metabolic process | response to progesterone | response to estradiol | positive regulation of adaptive immune response | positive regulation of epithelial to mesenchymal transition | carbohydrate derivative catabolic process | positive regulation of pathway-restricted SMAD protein phosphorylation | tolerance induction | immune system development | multicellular organismal reproductive process | ribose phosphate metabolic process | negative regulation of nucleic acid-templated transcription | purine nucleotide biosynthetic process | regulation of striated muscle tissue development | positive regulation of protein kinase activity | macromolecule localization | regulation of histone modification | regulation of chemotaxis | glycosaminoglycan catabolic process | nucleoside triphosphate metabolic process | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | myeloid dendritic cell differentiation | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | ribonucleotide metabolic process | negative regulation of T cell proliferation | positive regulation of cell division | pathway-restricted SMAD protein phosphorylation | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of bone mineralization | tissue development | regulation of binding | regulation of fat cell differentiation | regulation of cell differentiation | gamete generation | interspecies interaction between organisms | positive regulation of muscle cell differentiation | muscle structure development | negative regulation of cell motility | regulation of protein kinase B signaling | regulation of immune response | regulation of cellular process | leukocyte activation | cellular response to lipid | regulation of metabolic process | head morphogenesis | gliogenesis | catabolic process | regulation of protein complex assembly | negative regulation of mononuclear cell proliferation | cellular response to molecule of bacterial origin | protein import into nucleus | tolerance induction to self antigen | epidermal growth factor receptor signaling pathway | organic cyclic compound metabolic process | positive regulation of isotype switching to IgA isotypes | positive regulation of cellular protein metabolic process | epithelium development | cellular aromatic compound metabolic process | regulation of gene silencing by miRNA | cellular component organization | MAPK cascade | calcium ion homeostasis | response to transforming growth factor beta | regulation of cell division | urogenital system development | positive regulation of epithelial cell migration | T cell activation | protein export from nucleus | mammary gland morphogenesis | negative regulation of biomineral tissue development | positive regulation of interleukin-17 production | head development | regulation of peptide secretion | muscle organ morphogenesis | response to stimulus | vasculature development | purine nucleotide metabolic process | regulation of DNA recombination | regulation of regulatory T cell differentiation | regulation of cellular protein localization | regulation of peptidyl-tyrosine phosphorylation | oligodendrocyte development | embryonic epithelial tube formation | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | negative regulation of cell adhesion | mononuclear cell proliferation | carboxylic acid catabolic process | positive regulation of immunoglobulin production | gland morphogenesis | regulation of SMAD protein signal transduction | response to stress | intracellular protein transport | negative regulation of lymphocyte activation | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | positive regulation of transdifferentiation | regulation of mammary gland epithelial cell proliferation | tube morphogenesis | cardiac muscle tissue development | positive regulation of cell-cell adhesion | protein localization to nucleus | muscle tissue morphogenesis | hematopoietic progenitor cell differentiation | positive regulation of protein deacetylation | programmed cell death | positive regulation of mammary gland epithelial cell proliferation | regulation of transcription regulatory region DNA binding | positive regulation of cell activation | epithelial tube formation | reproduction | cellular localization | positive regulation of superoxide anion generation | response to alcohol | cardiovascular system development | cardiac ventricle morphogenesis | response to molecule of bacterial origin | positive regulation of fibroblast migration | regulation of gene silencing | cellular nitrogen compound metabolic process | axis elongation | positive regulation of T cell activation | extracellular matrix organization | regulation of DNA binding | positive regulation of blood vessel endothelial cell migration | cellular response to organic cyclic compound | ERBB signaling pathway | negative regulation of muscle tissue development | carbohydrate derivative biosynthetic process | regulation of protein transport | blood circulation | myeloid dendritic cell activation | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | hemopoiesis | cellular component assembly | protein modification process | regulation of actin cytoskeleton reorganization | regulation of odontogenesis | cartilage development | regulation of peptide transport | regulation of cell adhesion | cellular biosynthetic process | kidney development | embryo development | regulation of phosphatidylinositol 3-kinase activity | regulation of morphogenesis of a branching structure | macromolecule modification | positive regulation of protein dephosphorylation | activation of protein kinase activity | positive regulation of production of miRNAs involved in gene silencing by miRNA | regulation of intracellular transport | molecular function regulator | nucleotide biosynthetic process | metal ion homeostasis | regulation of lymphocyte differentiation | blood vessel development | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | leukocyte differentiation | locomotion | apoptotic process | protein kinase B signaling | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | regulation of skeletal muscle tissue development | regulation of superoxide metabolic process | response to external biotic stimulus | system development | chondrocyte differentiation | ATP biosynthetic process | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of organelle organization | ureteric bud development | negative regulation of growth | negative regulation of phosphate metabolic process | regulation of cartilage development | regulation of actin cytoskeleton organization | multicellular organism development | cell migration | positive regulation of lymphocyte differentiation | regulation of MAPK cascade | phosphorus metabolic process | regulation of collagen biosynthetic process | ribonucleoside monophosphate biosynthetic process | mammary gland development | protein import into nucleus, translocation | positive regulation of muscle organ development | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | negative regulation of cellular protein localization | hyaluronan metabolic process | regulation of ossification | positive regulation of chromosome organization | regulation of T cell activation | positive regulation of cell cycle | regulation of gene expression | positive regulation of chemotaxis | osteoclast differentiation | kidney epithelium development | negative regulation of gene silencing by miRNA | positive regulation of secretion | neural tube closure | organic substance transport | response to ketone | response to lipid | cell cycle | positive regulation of intracellular protein transport | myeloid leukocyte differentiation | organophosphate metabolic process | modification of morphology or physiology of other organism | negative regulation of cytokine production | regulation of cell cycle arrest | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | cellular ion homeostasis | animal organ morphogenesis | regulation of pri-miRNA transcription by RNA polymerase II | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | regulation of cell migration | enzyme linked receptor protein signaling pathway | response to cholesterol | small molecule metabolic process | regulation of vascular permeability | peptide transport | positive regulation of intracellular signal transduction | neural tube formation | positive regulation of protein complex assembly | regulation of cellular component movement | regulation of transcription by RNA polymerase II | negative regulation of interleukin-17 production | protein localization to organelle | negative regulation of myoblast differentiation | import into nucleus | positive regulation of cell differentiation | regulation of endothelial cell migration | nucleobase-containing small molecule metabolic process | homeostasis of number of cells | regulation of receptor clustering | positive regulation of cell migration | cell proliferation | membrane protein intracellular domain proteolysis | negative regulation of epithelial cell migration | leukocyte proliferation | positive regulation of protein localization to nucleus | biosynthetic process | neural tube development | regulation of cellular protein metabolic process | positive regulation of immunoglobulin mediated immune response | aromatic compound biosynthetic process | positive regulation of SMAD protein signal transduction | negative regulation of immune response | glial cell differentiation | positive regulation of ossification | phosphorylation | purine ribonucleotide biosynthetic process | mesonephric epithelium development | positive regulation of pri-miRNA transcription by RNA polymerase II | cellular protein-containing complex assembly | positive regulation of odontogenesis | regulation of interleukin-23 production | nucleoside triphosphate biosynthetic process | positive regulation of isotype switching | protein phosphorylation | mesonephros development | cation homeostasis | phosphate-containing compound metabolic process | sensory organ development | protein import | response to bacterium | regulation of lipid kinase activity | negative regulation of blood vessel endothelial cell migration | positive regulation of receptor clustering | negative regulation of cell-cell adhesion | chordate embryonic development | positive regulation of histone deacetylation | striated muscle tissue development | cellular cation homeostasis | cardiac muscle tissue morphogenesis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | transmembrane receptor protein serine/threonine kinase signaling pathway | positive regulation of protein localization to membrane | regulation of protein deacetylation | positive regulation of NAD+ ADP-ribosyltransferase activity | lymphocyte homeostasis | negative regulation of cell activation | inflammatory response | regulation of cytokine production involved in immune response | regulation of collagen metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | negative regulation of hyaluronan biosynthetic process | vasculogenesis | negative regulation of striated muscle tissue development | heart development | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | positive regulation of protein acetylation | renal system development | lipopolysaccharide-mediated signaling pathway | positive regulation of B cell activation | positive regulation of transport | regulation of phospholipid metabolic process | viral process | common-partner SMAD protein phosphorylation | regulation of hyaluronan biosynthetic process | negative regulation of cell growth | regulation of cellular response to growth factor stimulus | apoptotic signaling pathway | embryonic morphogenesis | regulation of mitotic cell cycle | drug metabolic process | carboxylic acid metabolic process | lymphocyte activation | positive regulation of molecular function | regulation of nucleocytoplasmic transport | cellular response to transforming growth factor beta stimulus | negative regulation of gene silencing | positive regulation of cell cycle arrest | lymph node development | multicellular organism reproduction | T cell differentiation | regulation of signaling receptor activity | receptor regulator activity | protein-containing complex assembly | heart valve development | negative regulation of carbohydrate metabolic process | negative regulation of epithelial cell proliferation | protein metabolic process | regulation of fibroblast proliferation | regulation of establishment of protein localization | cardiac ventricle development | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | regulation of cardiac muscle tissue development | receptor catabolic process | SMAD protein complex assembly | tissue morphogenesis | regulation of protein import into nucleus | regulation of hemopoiesis | cell cycle arrest | branching morphogenesis of an epithelial tube | regulation of protein dephosphorylation | regulation of kinase activity | response to wounding | regulation of animal organ morphogenesis | negative regulation of ossification | regulation of intracellular signal transduction | positive regulation of peptidyl-lysine acetylation | ventricular cardiac muscle tissue development | face morphogenesis | establishment of protein localization to organelle | positive regulation of vascular permeability | anatomical structure development | developmental growth involved in morphogenesis | kinase activator activity | branch elongation of an epithelium | mitotic cell cycle | cell surface receptor signaling pathway | growth factor activity | metabolic process | mesenchymal cell differentiation | dendritic cell differentiation | regulation of isotype switching | regulation of adaptive immune response | regulation of protein localization to plasma membrane | negative regulation of leukocyte proliferation | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of transcription, DNA-templated | embryonic organ development | regulation of myoblast differentiation | development of secondary sexual characteristics | negative regulation of mitotic cell cycle | cellular protein localization | oligodendrocyte differentiation | negative regulation of skeletal muscle tissue development | amide transport | chemical homeostasis | regulation of secretion | regulation of gene silencing by RNA | morphogenesis of embryonic epithelium | receptor ligand activity | development of secondary female sexual characteristics | immune response | nucleobase-containing compound metabolic process | positive regulation of cellular component biogenesis | heart valve morphogenesis | organic substance metabolic process | connective tissue development | nuclear transport | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | positive regulation of histone modification | negative regulation of cellular protein metabolic process | regulation of cell activation | negative regulation of cellular component movement | mammary gland branching involved in thelarche | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | regulatory T cell differentiation | ion homeostasis | regulation of striated muscle cell differentiation | regulation of phosphate metabolic process | regulation of chromosome organization | mammary gland epithelium development | positive regulation of binding | establishment of protein localization | T cell homeostasis | positive regulation of muscle tissue development | positive regulation of cytokine production | positive regulation of intracellular transport | positive regulation of endothelial cell migration | cell activation | positive regulation of MAPK cascade | morphogenesis of a branching epithelium | positive regulation of protein transport | camera-type eye development | regulation of peptidyl-serine phosphorylation | transforming growth factor beta receptor signaling pathway | anatomical structure formation involved in morphogenesis | negative regulation of cell cycle | negative regulation of protein metabolic process | regulation of epithelial cell migration | positive regulation of cardiac muscle cell differentiation | organonitrogen compound catabolic process | regulation of cell communication | regulation of blood vessel endothelial cell migration | signaling | regulation of immunoglobulin production | regulation of transcription, DNA-templated | glial cell development | response to organic cyclic compound | ribose phosphate biosynthetic process | cell development | positive regulation of DNA binding | regulation of T cell proliferation | protein localization | regulation of epithelial cell proliferation | organic acid metabolic process | regulation of production of small RNA involved in gene silencing by RNA | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | regulation of cytokine production | endoderm development | morphogenesis of a branching structure | anatomical structure morphogenesis | positive regulation of regulatory T cell differentiation | cellular macromolecule localization | positive regulation of MAP kinase activity | positive regulation of protein import into nucleus | extracellular matrix assembly | response to biotic stimulus | nucleocytoplasmic transport | positive regulation of gene silencing by miRNA | regulation of developmental process | regulation of ion transport | positive regulation of DNA metabolic process | germ cell migration | developmental process | regulation of muscle cell differentiation | positive regulation of protein import | positive regulation of cell cycle process | regulation of cell growth | cellular protein modification process | branch elongation involved in mammary gland duct branching | regulation of histone acetylation | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of histone acetylation | carbohydrate derivative metabolic process | regulation of transport | positive regulation of transcription, DNA-templated | modulation by virus of host morphology or physiology | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | regulation of cell-cell adhesion | embryonic liver development | regulation of superoxide anion generation | receptor metabolic process | positive regulation of nucleic acid-templated transcription | negative regulation of endothelial cell migration | positive regulation of lipid kinase activity | cellular metal ion homeostasis | tube closure | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | cardiac chamber development | heterocycle metabolic process | regulation of histone deacetylation | tube formation | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of lipid metabolic process | positive regulation of metabolic process | regulation of actin filament-based process | ossification | regulation of branching involved in mammary gland duct morphogenesis | positive regulation of lipid metabolic process | skeletal system development | negative regulation of lymphocyte proliferation | immune system process | mitotic cell cycle checkpoint | positive regulation of collagen biosynthetic process | cellular metabolic process | body morphogenesis | hematopoietic or lymphoid organ development | ATP metabolic process | cellular response to organic substance | regulation of protein localization | exocrine system development | positive regulation of cardiac muscle tissue development | positive regulation of cell motility | salivary gland development | response to steroid hormone | lens fiber cell differentiation | cell cycle checkpoint | circulatory system development | branching involved in mammary gland duct morphogenesis | divalent inorganic cation homeostasis | negative regulation of locomotion | positive regulation of nucleocytoplasmic transport | sexual reproduction | positive regulation of leukocyte cell-cell adhesion | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of bone mineralization | lens development in camera-type eye | muscle organ development | regulation of cytoskeleton organization | response to other organism | positive regulation of signaling | nucleoside monophosphate biosynthetic process | signal transduction | regulation of signaling | mesonephric tubule development | regulation of pathway-restricted SMAD protein phosphorylation | hyaluronan catabolic process | positive regulation of gene expression | positive regulation of transcription regulatory region DNA binding | negative regulation of production of miRNAs involved in gene silencing by miRNA | cellular response to growth factor stimulus | glycosaminoglycan metabolic process | cellular response to lipopolysaccharide | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process | cell-cell junction organization | regulation of chromatin organization | face development | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | extracellular matrix | actin-based cell projection | cell | cytoplasm | intracellular organelle | cell projection | extracellular region | microvillus | membrane-bounded organelle | nucleus | organelle | extracellular space | blood microparticle | cell surface | intracellular
