QuickView for tgfb1;jsessionid=0BB13860637A31AF00E9217BABBBA742;jsessionid=2431F072E57E16A0084D5803E554292C (gene)
- Gene Symbol:
- TGFB1
Canis lupus familiaris - Full name:
- transforming growth factor, beta 1
- Synonyms:
- N/A
- Genomic Location:
- Chr 1: 115538137-115552350
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , Bos taurus , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
transforming growth factor beta receptor binding | signaling receptor binding | cytokine receptor binding | molecular function regulator | antigen binding | type I transforming growth factor beta receptor binding | protein binding | receptor regulator activity | growth factor activity | receptor ligand activity | type III transforming growth factor beta receptor binding | type II transforming growth factor beta receptor binding
GO Biological Process
positive regulation of immune response | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | membrane protein proteolysis | purine ribonucleotide metabolic process | purine ribonucleoside monophosphate biosynthetic process | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of dephosphorylation | regulation of intracellular protein transport | negative regulation of immune system process | negative regulation of macrophage cytokine production | extracellular structure organization | positive regulation of cellular component organization | regulation of B cell activation | cell motility | response to lipopolysaccharide | regulation of cellular localization | intracellular signal transduction | nuclear export | proteolysis | regulation of localization | positive regulation of collagen metabolic process | regulation of carbohydrate metabolic process | positive regulation of peptidyl-threonine phosphorylation | establishment of localization | regulation of immune system process | response to hormone | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | negative regulation of RNA biosynthetic process | positive regulation of lymphocyte activation | regulation of protein import | cell differentiation | defense response | negative regulation of fat cell differentiation | epithelial to mesenchymal transition | response to drug | negative regulation of protein phosphorylation | positive regulation of biomineral tissue development | positive regulation of DNA recombination | bone remodeling | positive regulation of phosphate metabolic process | ossification involved in bone remodeling | positive regulation of cellular component movement | regulation of fibroblast migration | positive regulation of protein secretion | mesenchyme development | salivary gland morphogenesis | intracellular transport | positive regulation of dephosphorylation | positive regulation of phosphatidylinositol 3-kinase activity | positive regulation of cellular biosynthetic process | cellular process | negative regulation of muscle organ development | evasion or tolerance of host defenses by virus | organic substance catabolic process | regulation of cell motility | localization | extrinsic apoptotic signaling pathway | protein transport | tissue remodeling | nucleotide metabolic process | positive regulation of immune effector process | positive regulation of peptidyl-serine phosphorylation | positive regulation of reactive oxygen species metabolic process | response to progesterone | response to estradiol | positive regulation of adaptive immune response | positive regulation of epithelial to mesenchymal transition | carbohydrate derivative catabolic process | positive regulation of pathway-restricted SMAD protein phosphorylation | immune system development | ribose phosphate metabolic process | negative regulation of nucleic acid-templated transcription | purine nucleotide biosynthetic process | regulation of striated muscle tissue development | positive regulation of protein kinase activity | macromolecule localization | regulation of chemotaxis | glycosaminoglycan catabolic process | nucleoside triphosphate metabolic process | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | ribonucleotide metabolic process | positive regulation of cell division | pathway-restricted SMAD protein phosphorylation | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of bone mineralization | tissue development | regulation of binding | regulation of fat cell differentiation | regulation of cell differentiation | interspecies interaction between organisms | negative regulation of cell motility | regulation of protein kinase B signaling | regulation of immune response | regulation of cellular process | cellular response to lipid | regulation of metabolic process | catabolic process | regulation of protein complex assembly | cellular response to molecule of bacterial origin | protein import into nucleus | epidermal growth factor receptor signaling pathway | organic cyclic compound metabolic process | positive regulation of isotype switching to IgA isotypes | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | cellular component organization | MAPK cascade | response to transforming growth factor beta | regulation of cell division | positive regulation of epithelial cell migration | protein export from nucleus | positive regulation of interleukin-17 production | regulation of peptide secretion | response to stimulus | purine nucleotide metabolic process | regulation of DNA recombination | regulation of cellular protein localization | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | negative regulation of cell adhesion | carboxylic acid catabolic process | positive regulation of immunoglobulin production | gland morphogenesis | regulation of SMAD protein signal transduction | response to stress | intracellular protein transport | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | protein localization to nucleus | hematopoietic progenitor cell differentiation | programmed cell death | regulation of transcription regulatory region DNA binding | positive regulation of cell activation | cellular localization | positive regulation of superoxide anion generation | response to alcohol | response to molecule of bacterial origin | positive regulation of fibroblast migration | cellular nitrogen compound metabolic process | extracellular matrix organization | regulation of DNA binding | positive regulation of blood vessel endothelial cell migration | cellular response to organic cyclic compound | ERBB signaling pathway | negative regulation of muscle tissue development | carbohydrate derivative biosynthetic process | regulation of protein transport | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | hemopoiesis | cellular component assembly | protein modification process | cartilage development | regulation of peptide transport | regulation of cell adhesion | cellular biosynthetic process | regulation of phosphatidylinositol 3-kinase activity | macromolecule modification | positive regulation of protein dephosphorylation | regulation of intracellular transport | molecular function regulator | nucleotide biosynthetic process | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | locomotion | apoptotic process | protein kinase B signaling | regulation of skeletal muscle tissue development | regulation of superoxide metabolic process | response to external biotic stimulus | system development | chondrocyte differentiation | ATP biosynthetic process | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of growth | negative regulation of phosphate metabolic process | multicellular organism development | cell migration | regulation of MAPK cascade | phosphorus metabolic process | regulation of collagen biosynthetic process | ribonucleoside monophosphate biosynthetic process | protein import into nucleus, translocation | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | hyaluronan metabolic process | regulation of ossification | regulation of gene expression | positive regulation of chemotaxis | positive regulation of secretion | organic substance transport | response to ketone | response to lipid | cell cycle | positive regulation of intracellular protein transport | organophosphate metabolic process | modification of morphology or physiology of other organism | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | animal organ morphogenesis | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | response to cholesterol | small molecule metabolic process | peptide transport | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | regulation of cellular component movement | regulation of transcription by RNA polymerase II | protein localization to organelle | negative regulation of myoblast differentiation | import into nucleus | positive regulation of cell differentiation | regulation of endothelial cell migration | nucleobase-containing small molecule metabolic process | positive regulation of cell migration | membrane protein intracellular domain proteolysis | negative regulation of epithelial cell migration | positive regulation of protein localization to nucleus | biosynthetic process | regulation of cellular protein metabolic process | positive regulation of immunoglobulin mediated immune response | aromatic compound biosynthetic process | positive regulation of SMAD protein signal transduction | negative regulation of immune response | positive regulation of ossification | phosphorylation | purine ribonucleotide biosynthetic process | cellular protein-containing complex assembly | nucleoside triphosphate biosynthetic process | positive regulation of isotype switching | protein phosphorylation | phosphate-containing compound metabolic process | protein import | response to bacterium | regulation of lipid kinase activity | negative regulation of blood vessel endothelial cell migration | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | transmembrane receptor protein serine/threonine kinase signaling pathway | positive regulation of NAD+ ADP-ribosyltransferase activity | inflammatory response | regulation of cytokine production involved in immune response | regulation of collagen metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | negative regulation of hyaluronan biosynthetic process | negative regulation of striated muscle tissue development | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | lipopolysaccharide-mediated signaling pathway | positive regulation of B cell activation | positive regulation of transport | regulation of phospholipid metabolic process | viral process | common-partner SMAD protein phosphorylation | regulation of hyaluronan biosynthetic process | negative regulation of cell growth | regulation of cellular response to growth factor stimulus | apoptotic signaling pathway | regulation of mitotic cell cycle | drug metabolic process | carboxylic acid metabolic process | positive regulation of molecular function | regulation of nucleocytoplasmic transport | cellular response to transforming growth factor beta stimulus | regulation of signaling receptor activity | receptor regulator activity | protein-containing complex assembly | negative regulation of carbohydrate metabolic process | negative regulation of epithelial cell proliferation | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | receptor catabolic process | SMAD protein complex assembly | regulation of protein import into nucleus | cell cycle arrest | regulation of protein dephosphorylation | regulation of kinase activity | response to wounding | regulation of intracellular signal transduction | establishment of protein localization to organelle | anatomical structure development | mitotic cell cycle | cell surface receptor signaling pathway | growth factor activity | metabolic process | mesenchymal cell differentiation | regulation of isotype switching | regulation of adaptive immune response | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of transcription, DNA-templated | regulation of myoblast differentiation | negative regulation of mitotic cell cycle | cellular protein localization | negative regulation of skeletal muscle tissue development | amide transport | regulation of secretion | receptor ligand activity | nucleobase-containing compound metabolic process | positive regulation of cellular component biogenesis | organic substance metabolic process | connective tissue development | nuclear transport | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | negative regulation of cellular protein metabolic process | regulation of cell activation | negative regulation of cellular component movement | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | regulation of phosphate metabolic process | positive regulation of binding | establishment of protein localization | positive regulation of cytokine production | positive regulation of intracellular transport | positive regulation of endothelial cell migration | positive regulation of MAPK cascade | positive regulation of protein transport | regulation of peptidyl-serine phosphorylation | transforming growth factor beta receptor signaling pathway | negative regulation of cell cycle | negative regulation of protein metabolic process | regulation of epithelial cell migration | organonitrogen compound catabolic process | regulation of cell communication | regulation of blood vessel endothelial cell migration | signaling | regulation of immunoglobulin production | regulation of transcription, DNA-templated | response to organic cyclic compound | ribose phosphate biosynthetic process | positive regulation of DNA binding | protein localization | regulation of epithelial cell proliferation | organic acid metabolic process | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | anatomical structure morphogenesis | cellular macromolecule localization | positive regulation of MAP kinase activity | positive regulation of protein import into nucleus | extracellular matrix assembly | response to biotic stimulus | nucleocytoplasmic transport | regulation of developmental process | positive regulation of DNA metabolic process | developmental process | positive regulation of protein import | regulation of cell growth | cellular protein modification process | carbohydrate derivative metabolic process | regulation of transport | positive regulation of transcription, DNA-templated | modulation by virus of host morphology or physiology | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | regulation of cell-cell adhesion | regulation of superoxide anion generation | receptor metabolic process | positive regulation of nucleic acid-templated transcription | negative regulation of endothelial cell migration | positive regulation of lipid kinase activity | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | heterocycle metabolic process | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of lipid metabolic process | positive regulation of metabolic process | ossification | positive regulation of lipid metabolic process | skeletal system development | immune system process | mitotic cell cycle checkpoint | positive regulation of collagen biosynthetic process | cellular metabolic process | hematopoietic or lymphoid organ development | ATP metabolic process | cellular response to organic substance | regulation of protein localization | exocrine system development | positive regulation of cell motility | salivary gland development | response to steroid hormone | cell cycle checkpoint | negative regulation of locomotion | positive regulation of nucleocytoplasmic transport | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of bone mineralization | response to other organism | positive regulation of signaling | nucleoside monophosphate biosynthetic process | signal transduction | regulation of signaling | regulation of pathway-restricted SMAD protein phosphorylation | hyaluronan catabolic process | positive regulation of gene expression | positive regulation of transcription regulatory region DNA binding | cellular response to growth factor stimulus | glycosaminoglycan metabolic process | cellular response to lipopolysaccharide | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process | cell-cell junction organization | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | actin-based cell projection | cell | cytoplasm | intracellular organelle | cell projection | extracellular region | microvillus | membrane-bounded organelle | nucleus | organelle | extracellular space | blood microparticle | cell surface | intracellular
