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25-hydroxycholesterol
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
CHAC1
DHCR24
TRIB3
SOAT2
LDLR
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Pathway Enrichment
Most Correlated Biogroups
FISCHER_DREAM_TARGETS
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP
MARSON_BOUND_BY_E2F4_UNSTIMULATED
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP
cytosol
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Curated Studies
Most Correlated Studies
25-hydroxycholesterol effects on human hepatocyte against HCV
Macrophages and epithelial cells from Ch25h knockouts treated with poly I-C or 25-hydroxycholesterol
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Literature
Most Relevant Literature
25-Hydroxycholesterol exacerbates vascular leak during acute lung injury.
Serum 25-hydroxycholesterol levels are increased in patients with coronavirus disease 2019.
Pathogenic role of 25-hydroxycholesterol in cancer development and progression.
25-Hydroxycholesterol as a Signaling Molecule of the Nervous System.
25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes.
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Clinical Trials
Most Relevant Clinical Trials
Therapeutic Metabolic Intervention in Patients With Spastic Paraplegia SPG5
4beta-hydroxycholesterol in Cirrhosis
Genetic Polymorphysm of Cholesterol 24 S Hydroxylase in Patients With Glaucoma and AMD
Investigate Effect of Secukinumab on the PK of Midazolam in Patients With Mod to Sev Plaque Psoriasi…
AZD9496 First Time in Patients Ascending Dose Study
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