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ABT-737
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Summary
General Info
Genetic Markers
Most Correlated Genes
MAL
LCN2
AGR2
CRIP1
NPR3
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Pathway Enrichment
Most Correlated Biogroups
regulation of nitrogen compound metabolic process
cytosol
organic cyclic compound binding
heterocyclic compound binding
cell periphery
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Curated Studies
Most Correlated Studies
Small cell lung cancer cell line profiling based on the response to the BCL2 inhibitor ABT-737
Mantle cell lymphoma cell lines sensitive or resistant to the BH3 mimetic ABT-737
L1000 CMAP - Neural progenitor NPC.CAS9 cells treated with small molecule perturbagens
L1000 CMAP - Hepatocellular carcinoma HEPG2 cells treated with small molecule perturbagens
L1000 CMAP - Bone marrow CD34 cells treated with small molecule perturbagens
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Literature
Most Relevant Literature
ABT-737 suppresses aberrant Hedgehog pathway and overcomes resistance to smoothened antagonists by b…
ABT-737, a BH3 Mimetic, Enhances the Therapeutic Effects of Ionizing Radiation in K-ras Mutant Non-S…
Comparison of putative BH3 mimetics AT-101, HA14-1, sabutoclax and TW-37 with ABT-737 in platelets.
Differentiation of acute myeloid leukemia (AML) cells with ATRA reduces 18F-FDG uptake and increases…
ML355 Modulates Platelet Activation and Prevents ABT-737 Induced Apoptosis in Platelets.
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Clinical Trials
Most Relevant Clinical Trials
Ex Vivo Evaluation of the Interest of the Association of Platinum With a Molecule BH3-mimetic ABT-73…
A Phase 2a Study Evaluating the Safety and Efficacy of ABT-981 in Patients With Erosive Hand Osteoar…
Studying Samples From Patients With T-Cell Acute Lymphoblastic Leukemia
Efficacy and Safety Study for Subjects With Mild-to-Moderate Alzheimer's Disease
ABT-751 in Treating Young Patients With Refractory Solid Tumors
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