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QuickView for Alvocidib (compound)


Genetic Markers

Most Correlated Genes

  1. XIST
  2. RBP4
  3. CRIP1
  4. TNFAIP3
  5. ID4
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Pathway Enrichment

Most Correlated Biogroups

  1. regulation of nitrogen compound metabolic process
  2. cell periphery
  3. organic cyclic compound binding
  4. heterocyclic compound binding
  5. vesicle
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Curated Studies

Most Correlated Studies

  1. A2780 and MCF7 cancer cell lines treated with CDK, HSP90, and topoisomerase inhibitors
  2. L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
  3. L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
  4. L1000 CMAP - Hepatocellular carcinoma HEPG2 cells treated with small molecule perturbagens
  5. L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
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Literature

Most Relevant Literature

  1. The Pharmacological Implications of Flavopiridol: An Updated Overview.
  2. Analytical Quality-by-Design-Based Systematic Optimization of RP-HPLC Method Conditions to Analyze S…
  3. Enhanced Anti-tumor Effect of Flavopiridol in Combination With Gemcitabine in Pancreatic Cancer.
  4. Flavopiridol Protects against Fungal Keratitis due to Aspergillus fumigatus by Alleviating Inflammat…
  5. Modulation of Primary Cilia by Alvocidib Inhibition of CILK1.
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Clinical Trials

Most Relevant Clinical Trials

  1. Alvocidib in Treating Patients With Locally Advanced or Metastatic Solid Tumors
  2. Vorinostat and Alvocidib in Treating Patients With Advanced Solid Tumors
  3. Gemcitabine Hydrochloride and Alvocidib in Treating Patients With Solid Tumors
  4. Alvocidib Biomarker-driven Phase 2 AML Study
  5. A Study of Venetoclax and Alvocidib in Patients With Relapsed/Refractory Acute Myeloid Leukemia
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