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QuickView for C1 complement (compound)


Genetic Markers

Most Correlated Genes

  1. LDLR
  2. A330040F15Rik
  3. SRGN
  4. Gm15987
  5. CLEC2B
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Pathway Enrichment

Most Correlated Biogroups

  1. BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP
  2. response to organic substance
  3. MODULE_84
  4. regulation of cellular component organization
  5. KRIEG_HYPOXIA_NOT_VIA_KDM3A
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Curated Studies

Most Correlated Studies

  1. Macrophages treated with oxidized or acetylated low-density lipoprotein and complement protein C1q
  2. C1q elicited macrophage gene expression
  3. Leukemic cells' transcriptomic profiles in response to decreased TNFa expression
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Literature

Most Relevant Literature

  1. HMGB1 cleavage by complement C1s and its potent anti-inflammatory product.
  2. Outer surface lipoproteins from the Lyme disease spirochete exploit the molecular switch mechanism o…
  3. Quantitative Visualization of the Interaction between Complement Component C1 and Immunoglobulin G: …
  4. Noncanonical Functions of C1s Complement Its Canonical Functions in Renal Cancer.
  5. The Crystal Structure of the Michaelis-Menten Complex of C1 Esterase Inhibitor and C1s Reveals Novel…
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Clinical Trials

Most Relevant Clinical Trials

  1. Safety & Tolerability of Berinert® (C1 Inhibitor) Therapy to Prevent Rejection
  2. Complement and Graft-versus-host Disease
  3. Kinetics, Efficacy and Safety of C1-Esteraseremmer-N
  4. Pharmacokinetics of C1 Esterase Inhibitor in Hereditary Angioedema Subjects
  5. Human C1 Esterase Inhibitor (C1-INH) in Subjects With Acute Abdominal or Facial Hereditary Angioedem…
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