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QuickView for CYP51 inhibitors (compound)


Genetic Markers

Most Correlated Genes

  1. CYP1A1
  2. STAC3
  3. CA3
  4. TSKU
  5. CEP104
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Pathway Enrichment

Most Correlated Biogroups

  1. response to organic substance
  2. cytosol
  3. GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN
  4. heterocyclic compound binding
  5. PILON_KLF1_TARGETS_DN
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Curated Studies

Most Correlated Studies

  1. Liver Pharmacology and Xenobiotic Response Repertoire
  2. Yeast resistance to antifungal drugs: fluconazole and amphotericin B
  3. Diverse liver drug signatures
  4. Identification of biomarkers distinguishing chemical contaminants using rat hepatocytes
  5. Hepatocytes from male wistar rats treated with 14 hepatotoxicants
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Literature

Most Relevant Literature

  1. Oteseconazole: First Approved Orally Bioavailable and Selective CYP51 Inhibitor for the Treatment of…
  2. Design, Synthesis, Bioactive Evaluation, and Molecular Dynamics Simulation of Novel 4H-Pyrano[3,2-c]…
  3. Controlling antifungal activity with light: Optical regulation of fungal ergosterol biosynthetic pat…
  4. Planning new Trypanosoma cruzi CYP51 inhibitors using QSAR studies.
  5. Design, Synthesis, and Biological Evaluation of Dual-Target COX-2/CYP51 Inhibitors for the Treatment…
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Clinical Trials

Most Relevant Clinical Trials

  1. A Study to Evaluate the Efficacy and Safety of Oral VT-1161 in Patients With Onychomycosis of the To…
  2. A Study to Evaluate Oral VT-1161 in the Treatment of Patients With Recurrent Vaginal Candidiasis (Ye…
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