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QuickView for DOT1L (gene)


Body Atlas

Most Correlated Tissues

  1. Testes
  2. Bone marrow
  3. Kidney cortex
  4. Thymus gland
  5. Pituitary gland
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Disease Atlas

Most Correlated Diseases

  1. Pyloric ulcer
  2. Infection due to Mycobacterium tuberculosis
  3. Periodontitis
  4. Brucellosis
  5. Traumatic injury
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Pharmaco Atlas

Most Correlated Compounds

  1. marimastat
  2. trinitrophenyl-bovine serum albumin
  3. Puromycin
  4. 2,4-diaminoquinazoline
  5. Cobalt
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Knockdown Atlas

Most Correlated Gene Perturbations

  1. DOT1
  2. ZSCAN5A
  3. MYOC
  4. APEH
  5. MIR448
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Curated Studies

Most Correlated Studies

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Literature

Most Relevant Literature

  1. Proline-directed yeast and human MAP kinases phosphorylate the Dot1p/DOT1L histone H3K79 methyltrans…
  2. The disruptor of telomeric silencing 1-like (DOT1L) promotes peritoneal fibrosis through the upregul…
  3. DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1.
  4. DOT1L maintains NK cell phenotype and function for optimal tumor control.
  5. Dot1l cooperates with Npm1 to repress endogenous retrovirus MERVL in embryonic stem cells.
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Clinical Trials

Most Relevant Clinical Trials

  1. A Phase 1 Dose Escalation and Expanded Cohort Study of EPZ-5676 in the Treatment of Pediatric Patien…
  2. A Phase 1, Open-Label, Dose-Escalation & Expanded Cohort, Continuous IV Infusion, Multi-center Study…
  3. Testing Olaparib in Patients With Advanced or Metastatic (Cancer That Has Spread) Bladder Cancer and…
  4. Pinometostat and Azacitidine in Treating Patients With Relapsed, Refractory, or Newly Diagnosed Acut…
  5. Pinometostat With Standard Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leuk…
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