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QuickView for LGI1 (gene)


Body Atlas

Most Correlated Tissues

  1. Thalamus lateral nuclei
  2. Caudate
  3. Accumbens
  4. Putamen
  5. Frontal cortex
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Disease Atlas

Most Correlated Diseases

  1. Multiple organ failure
  2. Duchenne muscular dystrophy
  3. Nerve injury
  4. Physical activity
  5. Muscle atrophy
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Pharmaco Atlas

Most Correlated Compounds

  1. CRA 024781
  2. ITF 2357
  3. pyroxamide
  4. 2,3-pentanedione
  5. HC toxin
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Knockdown Atlas

Most Correlated Gene Perturbations

  1. Pik3ca
  2. TARBP2P1
  3. PTH1R
  4. IDH2
  5. TOP2B
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Curated Studies

Most Correlated Studies

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Literature

Most Relevant Literature

  1. A novel Lgi1 mutation causes white matter abnormalities and impairs motor coordination in mice.
  2. LGI1 downregulation increases neuronal circuit excitability.
  3. 14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice.
  4. Inactivation of Lgi1 in murine neuronal precursor cells leads to dysregulation of axon guidance path…
  5. LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prev…
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Clinical Trials

Most Relevant Clinical Trials

  1. Core Cerebrospinal Fluid Biomarker Profile in Anti-Leucine Rich Glioma Inactivated 1 (Anti-LGI1) Enc…
  2. LGI1-antibody Patients Follow-up
  3. HLA Analysis in Autoimmune Encephalitis and Related Disorders
  4. Mechanisms of Auto-immune Encephalitis
  5. Study of Immunotherapy in Autoantibody Positive Psychosis
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